Protein Alignment CG42637 and gcy-13

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_506097.3
• Gene: gcy-13 / 191646
• WormBaseID: WBGene00001539
• Length: 1028
• Species: Caenorhabditis elegans
• Alignment Length: 1139
• Identity: 355/1139 - (31%)
• Similarity: 566/1139 - (49%)
• Gaps: 201/1139 - (17%)

  Fly    27 TVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRW-----NDTKGDTVLATKA 86
            :||:.|:             :.|:.:|:|.: |..:|:.|:.::..:     |:.|. ..|::|.
 Worm     4 SVGWQTS-------------ASAIEIAMDRI-KSEHLIDNIGINFIYVFDDCNEAKA-AGLSSKL 53

  Fly    87 ITEMICDGIATIFGPEGPCYVEAIVSQS--RNIPMISY----KCAEYRASAIPTFARTEPPDTQV 145
            :.:.   .::.|.||.......|:|:.:  .|.|::::    ..:....|..||.....|....:
 Worm    54 LMDA---NVSAIVGPTCNAAGLAVVNLAGYYNTPVLTWGLTISSSFIDTSKYPTTVTIVPVAKSI 115

  Fly   146 VKSLLALLRYYAWNKFSILY----------EDVWSPVADLLKDQATKRNMTIN-HKQSFID---- 195
            ..::..::..:.|.:|..::          :|:....:|   ...|..:.||. :.||:.:
 Worm   116 AAAIHEVMIQFEWTEFVYVFVEDEKCGYFRDDLEQITSD---SNYTSLSRTIQIYDQSYTNLVRQ 177

  Fly   196 -NRVKCCEQMLDCC--RSG---YWYQLVQNTMNRTR---IYVFLGAANSLVDFMSSMETAGLFAR 251
             .::|...::...|  .:|   ..:.|....::.|.   :|:|.|..::.....||        .
 Worm   178 LEKLKTVSRIFTVCLPEAGDIKRRFMLAAYDLDMTTDEYVYLFAGPKSTAYQQTSS--------T 234

  Fly   252 GEYMVIFVDMMVYSE----REAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQ 312
            |:.:.|:||   :||    |:.|.      ::.||             |::::||:....:.|..
 Worm   235 GDVVGIWVD---WSENPDGRDEEA------KLAFM-------------RTMVIVATPVQGEQYAA 277

  Fly   313 FTKQVQKYSSKPPFNL--EIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDD 375
            |.|:|.:....||:|.  |..    |..:.: .:.||..|:|::.|||..::|.:.|:.
 Worm   278 FKKEVIERMKLPPYNCVDECK----EKEYQE-AAEYADQLHDTIYLYALILNKTIEEQG------ 331

  Fly   376 VIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSV-----LAYK-PHKWNNSNNMP 434
              .|..:||:.::           ..|:.|:.      ||...|     :.|: |:.  |..|:.
 Worm   332 --IEQIANGSNIV-----------TRGAGIEF------EGMSGVVRMNGIGYRLPNM--NLANLD 375

  Fly   435 CNYHMVPVAY--FHQGEEHPEYKLINGSIDWPS-GGEKPADEPMCGFANELCKKD---DTHYTST 493
            .|.....|||  ......:..:.:|:.::.|.: .|:.|...|.||::.:.|..:   |..|...
 Worm   376 SNATQRTVAYMDIDSTSVNWTFAIIDQALIWDAYNGKLPQTRPECGYSGKSCPVNFFVDYLYIVV 440

  Fly   494 VAAVVLGVLLFCSGV-----ITMSIYRKWKIELEIE-----GLLWKIDPNEIKGYSGNEIVSSPS 548
            :.||:  ::|.|:..     :.:...|..::.|:.:     |:|..|    |||          .
 Worm   441 IVAVI--IVLCCAAAAIAAFLVIKARRDEELRLDDQWIVPHGMLQSI----IKG----------R 489

  Fly   549 KVSLMSAQSYGSRWTNQFVTSTG--------------RLRGAVVRIKELKFPRKRDISREIMK-- 597
            |.|..|::|..|..|    |:||              ..:|..|.:.|....||..:...|.|
 Worm   490 KESHHSSRSLQSNST----TTTGTTGISSRSVFFPETETQGYFVYMNEPVLARKYQLRVPIFKQD 550

  Fly   598 --EMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIK 660
              |:|:||.:.|||:|.|||.|::....:....||::||:.|:|....|.:|..||..||.|:..
 Worm   551 RSELRMLRSIEHDNVNRFIGLSIDGPVYMSFWRYCSRGSIKDVIAKSSINMDGFFIYCLIKDIAS 615

  Fly   661 GMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELL 725
            |:.|||:|.:..||:|.|..|.:..||.:::..:||..::...:....|       .|..|||:|
 Worm   616 GLQYIHHSPIKQHGSLTSECCYINDRWQVKIGSYGLSFMQGVEKRTEDG-------LLHTAPEVL 673

  Fly   726 RNHI-HGSQKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEIVDYVKKLPLKGEDPFRPEVESII 787
            |..: .|:|.||||:|:|:..|:......:...|  .|..||:..||:   .|..||||.::.:
 Worm   674 REGLTSGTQAGDVYSFSIVCSELVGHSSAWNLENRKEEADEIIFMVKR---GGRTPFRPSLDDV- 734

  Fly   788 EAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGK--TKNIMDQMMEMMEKYANNLEDI 850
             .:.....:|..|||||.|||::||...::...:|.|..|:  :.|:||.:..::||:|::|||.
 Worm   735 -DDDINPAMLHLIRDCWDEDPKQRPNIDMVNKLMKNMNSGRSGSANLMDHVFSVLEKHASSLEDE 798

  Fly   851 VTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPL 915
            |.||.:.|.|||.|::.||:|||||.|||:|.:||.|||.:::.|||:|||:||||.::.:||||
 Worm   799 VQERMKELVEEKKKSDILLYRMLPQQVAERLKLGQSVEPEAFESVTIFFSDVVGFTVLANKSTPL 863

  Fly   916 QVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHR 980
            ||||.||||||.||.||...|.||||||||||:||||||.:||..|...||:|:|||:.:::..:
 Worm   864 QVVNLLNDLYTTFDAIIEKNDSYKVETIGDAYLVVSGLPRRNGTEHVANIANMSLELMDSLQAFK 928

  Fly   981 IAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALD 1045
            |.|.|.|.:::|||||:|..|||||||||||||||||||||||||||||:...||:|:.|...|.
 Worm   929 IPHLPQEKVQIRIGMHSGSCVAGVVGLTMPRYCLFGDTVNTASRMESNGKPGFIHLSSDCYDLLT 993

  Fly  1046 KLGGGYITEKRGLVNMKGKGDVVTWWLTGANENA 1079
            .|...|.||.||.|.:||||.:.|:||.|..|.:
 Worm   994 SLYKEYNTESRGEVIIKGKGVMQTYWLLGMKEES 1027

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	90/466 (19%)
		PK_GC-A_B	543..827	CDD:270944	95/304 (31%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
gcy-13	NP_506097.3	PBP1_NPR_GC-like	1..396	CDD:380575	90/474 (19%)
		Protein Kinases, catalytic domain	548..770	CDD:473864	79/233 (34%)
		CYCc	808..1000	CDD:214485	119/191 (62%)