Protein Alignment CG42637 and gcy-5

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_496219.1
• Gene: gcy-5 / 191643
• WormBaseID: WBGene00001532
• Length: 1122
• Species: Caenorhabditis elegans
• Alignment Length: 1223
• Identity: 357/1223 - (29%)
• Similarity: 548/1223 - (44%)
• Gaps: 241/1223 - (19%)

  Fly     6 FNLLLLLSVAVRDC----SNHRTVLTVGYLTALTGDLKTRQG----LAISGALTMALDEVNKDPN 62
            |:::||..:...:|    |:.|| |.||...|    ..|:.|    .:..|.|.:|:..: |...
 Worm     6 FSMVLLWVLGASECQVIPSSRRT-LRVGIAAA----QDTQSGSIGWASCGGTLPIAVQYL-KSKG 64

  Fly    63 LLPNVYLDLRWNDTKGDTVLATKA----ITEM--------ICDGIATIFGPEGPCYVEAI----- 110
            .|.:..::.....|:.|.....||    :.||        .|.....|.|.....|.:.:
 Worm    65 FLTDFDVEYYMEYTECDRASVAKAGMKFMKEMNVDVVVGPSCGDALAIMGTLSAIYKKLVLGWGF 129

  Fly   111 -----VSQSRNIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY----- 165
                 ::.:...|        |.||..|| |:|....|.      .:|..:.:::.::||
 Worm   130 VSDTQLADTNRFP--------YVASVQPT-AQTLGLATS------RILEMFQFDRVALLYYKDDQ 179

  Fly   166 ---EDVWSPVADLLKD--------------QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSG-- 211
               :.|...|...|.|              |:....:|.:..|: :.:|.:.   :|.|..||
 Worm   180 DYCKSVMDDVEATLSDPDLYPVRIVWKGELQSDNEALTRSTLQA-VKSRARI---VLLCAISGPE 240

  Fly   212 ---YWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAG----------LFARG-----EYMVIF 258
               |...:.|..|          ..|..|..:.:|.:.|          .||.|     |...:.
 Worm   241 KRNYLISIAQQNM----------TTNEYVHILLTMRSIGYGVQTSLGKKTFANGLTPLWESFTVA 295

  Fly   259 VD-MMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVASTPPTKDYIQF-TKQVQKYS 321
            .| ....:.|.|||.|                        ::.|.|.....:::|: ||.:....
 Worm   296 PDGNETNARRAAEKML------------------------VIDVNSDVQDAEFLQYLTKNIADAV 336

  Fly   322 SKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTR 386
            ..||...........|:.|  :..||.:|:|...||..||.|:..      ||..::   .|...
 Worm   337 RNPPMKCNTSECINASSTS--MGSYARHLFDVFYLYGMAVSKLNS------TDPTVY---GNLNL 390

  Fly   387 VIDTIIKNRTYMSITGSKIKIDQ----------YGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVP 441
            ::..::  .::..:|| :::|.|          ||..|....|.......:|:|:.:...|....
 Worm   391 LMPQMV--TSFDGMTG-RVQIGQNLYRVPTYQLYGLDEKYEQVALVNMTFYNSSSQLSRGYSDEG 452

  Fly   442 VAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMCGFANELCKK---DDTHYTSTVAAVVL---- 499
            .:.:|               .|  .|.:|.|.|:|||:...|..   |.......||::||
 Worm   453 RSVWH---------------FW--DGTRPLDTPICGFSGRYCPVQFWDQYGVLIFVASIVLIFLI 500

  Fly   500 GVLLFCSGVITMSIYRKWKIELEIEGLLWKI-------------DPNEIKG-YSGNEIVSSPSKV 550
            .::|.|.|.    :.|..:.|.|.....|:|             .||..:. .||...::..||:
 Worm   501 CIMLMCFGF----MIRGRRAEQERLNSEWQIPSIQLIMPQKEKRKPNSRRSLQSGPSTITGESKM 561

  Fly   551 SLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKR---DISREIMKEMRLLRELRHDNINS 612
            ::..  .:...:|.|...            |:|....|.   .:::|..::...||:|.|||:|.
 Worm   562 TIDG--GFHENYTVQMFE------------KDLVLTTKHHSMQMNKEEKEKFVKLRKLEHDNLNK 612

  Fly   613 FIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLK 677
            |||.|::..:.:.|...|::|||.|||...:..:|..|:..:|.|:.:||.::|.|.|..||||:
 Worm   613 FIGLSIDGPQFVAVWKMCSRGSLQDIIARGNFSMDGFFMFCIITDIAEGMNFLHKSFLHLHGNLR 677

  Fly   678 SSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQ-LWRAPELLRNHIHGSQ---KGDVY 738
            |:.|:|...|.:::|||||..|        :.||...:.: ||.|||:||..:...|   ..|||
 Worm   678 SATCLVNDSWQVKLTDFGLGAL--------LEEHTPSKKRLLWAAPEVLRGSLTIHQMDPSADVY 734

  Fly   739 AFAIIMYEIFSRKGPFGQINFE--PKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIR 801
            :||||..||.:::..:...|.:  ..||:..|||   .|....|||:  |::||..| .:...::
 Worm   735 SFAIIASEILTKREAWDISNRKEGADEILYMVKK---GGNRTIRPEL--ILDAEVSP-RLTTLVK 793

  Fly   802 DCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTE 866
            |||:|.||:||:...|...|.:|......|:||.:..|:|:|.:.||..:.|||:.|..||.|.:
 Worm   794 DCWSEQPEDRPKAEQICKLLSEMTPRGNTNLMDHVFNMLEEYTSTLEVDIEERTKELTLEKKKAD 858

  Fly   867 DLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRI 931
            .||.||||:.|||:|..||.|||..:|.||:.|||:|.||.::|:.:|.||||.|||||:.||.|
 Worm   859 ILLSRMLPKQVAERLKAGQTVEPEGFDTVTVLFSDVVKFTQLAAKCSPFQVVNLLNDLYSNFDTI 923

  Fly   932 IRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMH 996
            |..:.|||||:|||.|:.|||||.|||..|..:|..|:|:.:...|..::.|.|.|.::||||::
 Worm   924 IEEHGVYKVESIGDGYLCVSGLPTKNGYAHIKQIVDMSLKFMDYCKSFKVPHLPREKVELRIGIN 988

  Fly   997 TGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKC-KLALDKLGGGYITEKRGLVN 1060
            :||.|||||||:|||||||||||||||||||||:...||:|... .|..|.....|.|..||.|.
 Worm   989 SGPCVAGVVGLSMPRYCLFGDTVNTASRMESNGKPSMIHMSEAAHSLLTDHYPHQYETSSRGEVI 1053

  Fly  1061 MKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSI 1113
            :||||.:.|:|:.|..::  ..|.:.....||  .:.....|::..|.::.::
 Worm  1054 IKGKGVMETFWVLGKTDS--DTKSLSTRTTPP--ITDENWPPQMKEDLKKRAV 1102

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	94/498 (19%)
		PK_GC-A_B	543..827	CDD:270944	94/292 (32%)
		HNOBA	<833..881	CDD:462234	23/47 (49%)
		CYCc	860..1052	CDD:214485	106/192 (55%)
gcy-5	NP_496219.1	PBP1_NPR_GC-like	30..439	CDD:380575	90/480 (19%)
		PK_GC	546..816	CDD:270894	95/297 (32%)
		HNOBA	<829..873	CDD:462234	21/43 (49%)
		CYCc	852..1042	CDD:214485	106/189 (56%)