DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and gcy-1

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_496039.1	Gene:	gcy-1 / 191639	WormBaseID:	WBGene00001528	Length:	1137	Species:	Caenorhabditis elegans

Alignment Length:	1231	Identity:	354/1231 - (28%)
Similarity:	563/1231 - (45%)	Gaps:	199/1231 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 FNLLLLL----SVAVRDCSN----HRTVLTVGYLTALTGDLKTRQ-GLAI-SGALTMALDEVNKD 60
            |.:|||.    |:.|::..:    .||..|:....|....::|.. |.:: .||:.:|::.: |:
Worm     4 FTILLLFNIFPSIFVQNLPDTTVAPRTKRTIKIGIAAAQRIQTSSIGWSVCGGAVPLAIERL-KE 67

  Fly    61 PNLLPNVYLDLRWNDTKGDTVLATKAITEMI-CDGIATIFGPEGPCYVEAIVSQSRNIPMISYKC 124
            ...:.:...:...:.|:.|.....:|..|.| ...:..|.||  ||        ::.:.::|:..
Worm    68 MGFVKDFDFEYIVDYTECDLGSVVRAGMEFIKTHKVDVIIGP--PC--------AQALRLMSFLA 122

  Fly   125 AEYRASAI----------------PTFARTEPPDTQVVKSLLALLRYYAWNKFSILY-------- 165
            ..|:...:                |......|....:..:...:|..:.||:.::||
Worm   123 ENYKKPVLGWGFVSDTDLSDVIRFPHLTTVIPNSLMLGYAASKMLTTFHWNRVALLYYFSDVKYC 187

  Fly   166 EDVWSPVADLLKDQATKR-NMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVF 229
            ..|.:.:.....|.:|.. |:.|..:....||      :..|        .:.|...:|.||  .
Worm   188 SGVMNDIEATFNDPSTPNVNIVIKAEIYLNDN------ETTD--------NVFQTVKSRARI--I 236

  Fly   230 LGAANSLV---DFMSSMETAGLFARGEYMVIFVDM--MVYSEREAEKYLRRVDQITFM------- 282
            |....:.|   |::..:.|..:.. .||:.|.:.|  :.:..:.:      :.:.||.
Worm   237 LWCTQTSVEKRDYLIKIATHDMIG-DEYVHIMLSMRNVAFGTQTS------LGKPTFSQSGLTPI 294

  Fly   283 --SNCHSTENFNQMARS------LLVVASTPPTKDYIQF-TKQVQKYSSKPPFNLEIPRLFVESN 338
              |....|:.|.:||:.      :|.|.|....|.|::: .|.:.|....||.|.........:
Worm   295 WESFTEGTDGFEKMAKQAATRMFVLDVNSEVADKKYLEYMQKNIIKAVQSPPMNCSTVECMTAN- 358

  Fly   339 FSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTD-DVI---FEVASNGTRVIDTIIKNRTYMS 399
             :..:..||.:|:|.|.||..|:......:..|..| ||:   |..:..|......|..|.|.|.
Worm   359 -TTIMGGYARHLFDVVYLYGIALTHTNSTDPAVYGDVDVLVHQFVTSFQGMTGHVVISPNLTRMP 422

  Fly   400 ITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMVP-VAYFHQGEEHPEYKLINGSIDW 463
            |      ...|| ...::..:|.....:.||       .||| |..|::.|         |...|
Worm   423 I------FQLYG-LNSDYDQVALVDFTYTNS-------VMVPNVTLFYKDE---------GGAVW 464

  Fly   464 P-SGGEKPADEPMCGFANELC-----KKDDTHYTSTVAAVVLGVLLFCSGVITM---------SI 513
            . .|..:|.|.|:|||..:.|     ::........:|.:||.||:...|.:.:         .|
Worm   465 SYYGHSRPLDIPICGFLGKSCPVSFWEQYKILIFVAIAVIVLMVLIMIIGCLCVISGKRAERARI 529

  Fly   514 YRKWKI--------ELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTST 570
            ..:|::        |.::.|          ||.|...:.|:||    :|....|....:.|..:.
Worm   530 NAEWQVPFAKLIESEKQVRG----------KGASRRSLQSAPS----ISTGHSGVTTVSDFCENY 580

  Fly   571 GRLRGAVVRIKELKFP----RKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCA 631
            ..:......:...|:.    .|.|..|.:.     :|:|.|:|||.|||.|::....:.||..|:
Worm   581 TMMMYEKEMVLTAKYQYTHLTKADKERFVK-----MRKLDHENINRFIGLSIDSAHFISVTKLCS 640

  Fly   632 KGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGL 696
            :|||.||:...:..:|..|:..:|.|:.||:.|:|.:.|..||||:|:.|:|...|.:::.::|:
Worm   641 RGSLQDILSRGNFSMDYFFMFCIIRDVAKGLEYLHKTFLRLHGNLRSATCLVNDSWQVKLAEYGM 705

  Fly   697 HELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQ---KGDVYAFAIIMYEIFSRKGPFGQIN 758
            ..|   .|.::..:    :..||.|||:||..:..||   ..|:|:||||..||.::|..:..::
Worm   706 DNL---VEEQTPPK----KRLLWVAPEVLRGSLSVSQMEPSADIYSFAIIASEILTKKEAWDILD 763

  Fly   759 FEP--KEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRL 821
            .:.  :|||..|||   .|..|.|||:  |.:.......::|.::|||||.||:||....|.:::
Worm   764 RKEDCEEIVYNVKK---GGLFPIRPEI--ITDIHDVNPALIALVKDCWAEVPEDRPTAENICSQM 823

  Fly   822 KKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQG 886
            |.:...:..|:||.:..|:|:|.:.||:.:.|||:.|..||.|.:.||.||||:.|||:|..||.
Worm   824 KGLVSKQKTNLMDHVFNMLEEYTSTLEEEIEERTKELTLEKKKADILLSRMLPKQVAERLKAGQT 888

  Fly   887 VEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVS 951
            |||..:|.||::|||:|.||.::::.:|.|.||.|||||:.||.||..:.|||||:|||.|:.||
Worm   889 VEPEGFDSVTVFFSDVVKFTILASKCSPFQTVNLLNDLYSNFDTIIEQHGVYKVESIGDGYLCVS 953

  Fly   952 GLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFG 1016
            |||.:||..|..:|..|:|:.:...|...|.|.|.|.::||||:::||.|||||||:||||||||
Worm   954 GLPTRNGYAHIKQIVDMSLKFMEYCKSFNIPHLPRENVELRIGVNSGPCVAGVVGLSMPRYCLFG 1018

  Fly  1017 DTVNTASRMESNGEALKIHISNKC-KLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAI 1080
            |||||||||||||:...||::|.. .|........|.|..||.|.:||||.:.|:|:.|......
Worm  1019 DTVNTASRMESNGKPSLIHLTNDAHSLLTTHYPNQYETSSRGEVIIKGKGVMETFWVHGRFGEME 1083

  Fly  1081 QKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSL 1141
            ..:|..:.:...|..:..|..|  ||.|...|            |.|:|...:.|...:.:
Worm  1084 PTELRSISNRSTPPVTNDRWIP--NPSSSHGS------------RPSSVYDPLQGHQKFKM 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	92/472 (19%)
		ANF_receptor	48..412	CDD:279440	80/414 (19%)
		PK_GC-A_B	543..827	CDD:270944	90/292 (31%)
		HNOBA	<835..881	CDD:285003	21/45 (47%)
		CYCc	860..1052	CDD:214485	103/192 (54%)
		Guanylate_cyc	887..1074	CDD:278633	99/187 (53%)
gcy-1	NP_496039.1	PBP1_NPR_GC_like	35..449	CDD:107347	87/463 (19%)
		ANF_receptor	53..432	CDD:279440	81/421 (19%)
		PKc_like	555..821	CDD:304357	89/286 (31%)
		HNOBA	<840..883	CDD:285003	21/42 (50%)
		CYCc	862..1051	CDD:214485	103/188 (55%)
		Guanylate_cyc	889..1077	CDD:278633	99/187 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810