DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and gcy-20

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_507101.1	Gene:	gcy-20 / 184797	WormBaseID:	WBGene00001545	Length:	1108	Species:	Caenorhabditis elegans

Alignment Length:	1155	Identity:	371/1155 - (32%)
Similarity:	561/1155 - (48%)	Gaps:	192/1155 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLLLLSVAVRDCSNHRT--------------VLTVGYLTALTGDLKTRQGLAISGALTMALDEVN 58
            |||||...:..|...:|              :.:|||.|:             :.|:.:|.|.:.
Worm     4 LLLLLQNILVFCQFLQTIKVGLMFSKDTASVIRSVGYRTS-------------AAAVLVAKDRIR 55

  Fly    59 KDPNLLPNVYLDLRWN---DTKGDTVLATKAITEMICDGIATIFGPEGPC----YVEAIVSQSRN 116
            .: :||..  .|..:.   |...:::.|.|.:..:..|.:..|.||  .|    ...|.::...|
Worm    56 AE-HLLDQ--YDFNFTIKFDECSESLAAGKVVELLTHDNVDVIIGP--TCNRAGVAVASLADFYN 115

  Fly   117 IPMISYKCAEYRASAIPTFARTEPPDTQVVKSL------LA---LLRYYAWNKFSILYEDVWSPV 172
            :|:..:...  ..:.|..|:|.:   |.|..||      ||   :||.|.|::|..:|    |..
Worm   116 VPVFQWGLT--TTADIGNFSRYQ---TTVTLSLDTHSISLAVREILRQYGWSEFVFIY----SND 171

  Fly   173 ADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTM----NRTRIYV--FLG 231
            .|..|..|.|.:|    ::..|:|.......|:..  .....:.:|.|:    .|.||.:  |..
Worm   172 GDEEKCAAMKDDM----EKMGIENSDVTMAYMIQI--QTVTMESLQRTLLEVSKRGRIIIACFAS 230

  Fly   232 AANSLVDFMSSMETAGLFARGEYMVIFVD-------------MMVYSEREAEKYLRRVDQITFMS 283
            .......|::|...||: :..||:.:|.:             .:.||..:.:..|     :|.::
Worm   231 GRGFKKAFIASTVLAGM-STEEYLYVFAEPQSRGFYVDEADGKVHYSWDDTDGQL-----VTGLT 289

  Fly   284 NCHSTENFNQMARSLLVVAS-----TPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVE--SNFS- 340
            |    |........:|.:..     |..|..|..||.||....::.|||.      |:  ||.|
Worm   290 N----EQIRDAYGKVLYICDNMGEPTTITTQYTNFTSQVISRMAEQPFNC------VQDCSNQSY 344

  Fly   341 KFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKI 405
            |..:.||..|.||...||:|::|.       ||.|.......||:.|:..|  ..|:..:.|..:
Worm   345 KHAATYAGQLADSFYAYAFALNKS-------LTQDPTRSNLKNGSFVLSNI--GMTFQGVGGEAV 400

  Fly   406 KIDQYGDS-------EGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDW 463
            .:|:.|..       ..|.|:|.|.      :.::..|...|....|::.|          |..|
Worm   401 TLDESGSRIVQVYMFAMNSSLLPYM------AASLLVNVSEVVFTPFYKSE----------SELW 449

  Fly   464 PSGGEKPADEPMCGFANELCKKDDTH----YTSTVA-AVVLGVLLFCSGVI-TMSIYRKWKIELE 522
               ..:|...|.|||....|..|...    ||...| .|:|.:|..|:|:: ||.:.||   |:|
Worm   450 ---SVRPLSRPKCGFTGLECPADFVKEYLVYTIIAAFIVILALLAGCAGLLYTMHMKRK---EME 508

  Fly   523 IEGLLWK---IDPNEIKGYSGNE-----IVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVR 579
            .:.|||:   ::..:::..|..|     ..|.||..:.|:.:|...  |..|:.....
Worm   509 RQDLLWQVAFVELQQVQSKSRAEASMHSFASGPSTSTKMTVESRTE--TTNFIFYHYH------- 564

  Fly   580 IKELKFPRKRDI----SREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIE 640
             :|:...:|.|:    ......|.|.:|...:||:|.|||..::..::|.:..:|::|||.|:|.
Worm   565 -QEVVAAKKHDLLVLFDANQKSEFRQMRNFDNDNLNKFIGLCLDGPQLLSLWRFCSRGSLSDVIS 628

  Fly   641 NEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAEN 705
            ...:::|..|:.|||.|:..|:.:||:|.|..||.|.|..|::..||.::::.|||..:|..
Worm   629 KSSMQMDSFFMFSLIRDISNGLYFIHSSFLKCHGQLTSRCCLIDDRWQIKISGFGLKSVRTF--- 690

  Fly   706 ESIGEHQHYRNQLWRAPELLRNHIHGS-QKGDVYAFAIIMYEIFSRKGPFGQIN--FEPKEIVDY 767
                |:....:.||.:||.|||..... .:||:|:|.||..||.:|...|...|  .:|..|:..
Worm   691 ----ENPKKEDLLWASPEYLRNEDQERLPEGDIYSFGIICAEILTRSSAFDLENRKEKPDVIIYQ 751

  Fly   768 VKKLPLKGEDPFRPEV---ESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKT 829
            |||   .|.:|.||.:   |:::...:    :|..:||||.|.|.|||....:|:.|..|:.|:.
Worm   752 VKK---GGHNPTRPSLDTGETVVINPA----LLHLVRDCWTERPSERPSIEQVRSHLNGMKDGRK 809

  Fly   830 KNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDL 894
            .|:||.:..|:|.||:.||:.|::||:.|.|||.|::.||:||||:.||:||.:||.|||.:::.
Worm   810 TNLMDHVFNMLETYASTLEEEVSDRTKELTEEKKKSDVLLYRMLPRMVADKLKLGQTVEPETFEQ 874

  Fly   895 VTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGD 959
            |||:|||:|.||.::.:.||||||..||||||:||.||...||||||||||.|:.|||||.:||:
Worm   875 VTIFFSDVVQFTTLAGKCTPLQVVTLLNDLYTIFDGIIEQNDVYKVETIGDGYLCVSGLPHRNGN 939

  Fly   960 RHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASR 1024
            .|...||.|:|..|.:::..|:.|.|.|.:.||||::.|.||||||||||||||||||.||||||
Worm   940 DHIRHIARMSLGFLSSLEFFRVQHLPAERINLRIGINCGSVVAGVVGLTMPRYCLFGDAVNTASR 1004

  Fly  1025 MESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |||||:..:||::.:....|.::.||:.||.||.|.:||||.:.|:||.|
Worm  1005 MESNGKPGQIHVTAEANRMLTQVVGGFRTESRGEVIIKGKGVMETFWLLG 1054

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	106/468 (23%)
		ANF_receptor	48..412	CDD:279440	95/406 (23%)
		PK_GC-A_B	543..827	CDD:270944	90/293 (31%)
		HNOBA	<835..881	CDD:285003	22/45 (49%)
		CYCc	860..1052	CDD:214485	111/191 (58%)
		Guanylate_cyc	887..1074	CDD:278633	107/186 (58%)
gcy-20	NP_507101.1	PBP1_NPR_GC_like	22..439	CDD:107347	106/480 (22%)
		ANF_receptor	44..418	CDD:279440	96/418 (23%)
		PKc_like	536..801	CDD:304357	88/288 (31%)
		STYKc	562..801	CDD:214568	81/260 (31%)
		HNOBA	<818..861	CDD:285003	22/42 (52%)
		CYCc	840..1032	CDD:214485	111/191 (58%)
		Guanylate_cyc	867..1054	CDD:278633	107/186 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	238	1.000	Domainoid score	I1279
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820