Protein Alignment CG42637 and Npr1

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_032753.5
• Gene: Npr1 / 18160
• MGIID: 97371
• Length: 1057
• Species: Mus musculus
• Alignment Length: 1142
• Identity: 404/1142 - (35%)
• Similarity: 602/1142 - (52%)
• Gaps: 182/1142 - (15%)

  Fly     9 LLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPN------- 66
            ||||...:...|.|.:.|||..:..||..........:..|:.:||..|...|:|||.
Mouse    14 LLLLPPLLLLRSGHASDLTVAVVLPLTNTSYPWSWARVGPAVELALGRVKARPDLLPGWTVRMVL 78

  Fly    67 -----------------VYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAIVSQS 114
                             ..:||:|..:.                  |...|| |..|..|.|.:.
Mouse    79 GSSENAAGVCSDTAAPLAAVDLKWEHSP------------------AVFLGP-GCVYSAAPVGRF 124

  Fly   115 R---NIPMISYKCA--------EYRASAIPTFARTEPPDTQVVKSLLALLRYYAW-NKFSILYED 167
            .   .:|:::....        ||   |:.|  ||.|...::...:.||.|...| ::..:||.|
Mouse   125 TAHWRVPLLTAGAPALGIGVKDEY---ALTT--RTGPSHVKLGDFVTALHRRLGWEHQALVLYAD 184

  Fly   168 -------VWSPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTR 225
                   .:..|..|......:.|:|:|| |.|::.            ...::.:|::....:.|
Mouse   185 RLGDDRPCFFIVEGLYMRVRERLNITVNH-QEFVEG------------DPDHYTKLLRTVQRKGR 236

  Fly   226 IYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTEN 290
            :.....:.::..:.|.....|||... :|:...:|:...|.:.|:..:.|       ......:.
Mouse   237 VIYICSSPDAFRNLMLLALDAGLTGE-DYVFFHLDVFGQSLQGAQGPVPR-------KPWERDDG 293

  Fly   291 FNQMAR-----SLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYL 350
            .::.||     :.::....|...:|::|.||::..:.| .||      |...:..|  :|..|..
Mouse   294 QDRRARQAFQAAKIITYKEPDNPEYLEFLKQLKLLADK-KFN------FTMEDGLK--NIIPASF 349

  Fly   351 YDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEG 415
            :|.:.||..||.:.|.:...|          ::|..:... :.||::..:|| .:|||:.||.:.
Mouse   350 HDGLLLYVQAVTETLAQGGTV----------TDGENITQR-MWNRSFQGVTG-YLKIDRNGDRDT 402

  Fly   416 NFSVLAYKPH--------KWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPAD 472
            :||:....|.        .:|.::.     .::.|:      ||..|        ||. |..|.|
Mouse   403 DFSLWDMDPETGAFRVVLNFNGTSQ-----ELMAVS------EHRLY--------WPL-GYPPPD 447

  Fly   473 EPMCGFANE--LCKKDDTHYTSTVAAVVLGVLLFCSG-VITMSIYRKWKIELEIEGLLWKI---- 530
            .|.|||.||  .|.:|  |:::.....::|.|...|. :::..||||.::|.|:...||::
Mouse   448 IPKCGFDNEDPACNQD--HFSTLEVLALVGSLSLVSFLIVSFFIYRKMQLEKELVSELWRVRWED 510

  Fly   531 -DPNEIKGYSGNEIVSSPSKVSLMS-AQSYGSRWTN----QFVTSTGRLRGAVVRIKELKFPRKR 589
             .|:.::    ..:.|:.|:::|.. ..:|||..|.    |....|...:|.:|.:|.:.  |||
Mouse   511 LQPSSLE----RHLRSAGSRLTLSGRGSNYGSLLTTEGQFQVFAKTAYYKGNLVAVKRVN--RKR 569

  Fly   590 -DISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIAS 653
             :::|:::.|::.:|:::::::..|:||..:|..|.::|:||.:|||.||:|||.|.||.:|..|
Mouse   570 IELTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYS 634

  Fly   654 LIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQL 718
            |.:|::|||:::||..:..|||||||||||..|::|::||:||...|   :.|....|..:..:|
Mouse   635 LTNDIVKGMLFLHNGAIGSHGNLKSSNCVVDGRFVLKITDYGLESFR---DPEPEQGHTLFAKKL 696

  Fly   719 WRAPELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGED- 777
            |.||||||   ....|||.||||:|.||:.||..|.|.|  ..::..||||::.|    .:||.
Mouse   697 WTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGVFYVEGLDLSPKEIIERV----TRGEQP 757

  Fly   778 PFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEK 842
            ||||.    ::.:|..:.:...::.||||||:|||.|..||..|:|.....:.||:|.::..||:
Mouse   758 PFRPS----MDLQSHLEELGQLMQRCWAEDPQERPPFQQIRLALRKFNKENSSNILDNLLSRMEQ 818

  Fly   843 YANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTA 907
            ||||||::|.|||:...|||.|.|.||:::||.||||:|..|:.|:..::|.|||||||||||||
Mouse   819 YANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTA 883

  Fly   908 MSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALEL 972
            :||||||:|||..||||||.||.:|..:|||||||||||||||||||::||..||.|:|.|||.|
Mouse   884 LSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGQLHAREVARMALAL 948

  Fly   973 LHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            |.||:..||.|||.|.|:||||:|||||.||||||.||||||||||||||||||||||||:||:|
Mouse   949 LDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALRIHLS 1013

  Fly  1038 NKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            ::.|..|::. .|:..|.||.|.|||||.|.|:||.|
Mouse  1014 SETKAVLEEF-DGFELELRGDVEMKGKGKVRTYWLLG 1049

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	93/474 (20%)
		PK_GC-A_B	543..827	CDD:270944	115/295 (39%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	132/191 (69%)
Npr1	NP_032753.5	PBP1_NPR_A	32..439	CDD:380608	95/491 (19%)
		PK_GC-A_B	530..803	CDD:270944	112/285 (39%)
		HNOBA	<809..857	CDD:462234	26/47 (55%)
		CYCc	836..1025	CDD:214485	131/189 (69%)