DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and acy-4

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_504486.4	Gene:	acy-4 / 178949	WormBaseID:	WBGene00000071	Length:	1013	Species:	Caenorhabditis elegans

Alignment Length:	446	Identity:	115/446 - (25%)
Similarity:	190/446 - (42%)	Gaps:	77/446 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   650 FIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQ----VTDFGLHELRQCAENESIGE 710
            |:..:...|...||:|....|:.|..|.|  .|:...::|.    |...|::|.:...:.|...:
Worm   610 FVPQMFIVLTSVMIFILTRALIKHARLVS--LVIGVLFILLSIQIVILMGMYESKFTCDVEKCFK 672

  Fly   711 HQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKG 775
            :.:  ...:...|:.           ..|..:|:...|..|.....|.|....::...|.:.:.
Worm   673 NNY--TDFFEIFEIC-----------TLATCVILSVDFMTKLLMSMIYFSSFTVLITAKLIRIN- 723

  Fly   776 EDPFRPEVESIIE--AESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMME 838
                  :.|:::.  |..|   ||:|:..........|.|.....:.:.|::.      :|:.::
Worm   724 ------QYEALLSTYANFC---VLSCLTLLLVVFSTRRSELISRYDFIWKLQA------LDEQLQ 773

  Fly   839 MMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVA----EKLTMGQGVEPVSYDLVTIYF 899
            |..|:..|                   ..:|..:||..||    |..|....:...|.|...|.|
Worm   774 MKRKHEQN-------------------RSVLENILPSHVAKHFVEDATSVSKLYHESRDNACIMF 819

  Fly   900 SDIVGFTAMSAE----STPLQVVNFLNDLYTVFDRII-------RGYDVYKVETIGDAYMVVSGL 953
            :.:..|.....|    :..::.:..||::.:.||:|:       ....:.|::||...|||.|||
Worm   820 ATLTEFDKFYIECDGNNEGVECLRLLNEIISDFDQILDQILDREEFKKIEKIKTISTTYMVASGL 884

  Fly   954 PIKN-GDR-HAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFG 1016
            ..:. ||. |...||..|.|||..::...| |..| ...||||::.|||||||:|...|.|.::|
Worm   885 AGRECGDNSHVEAIALFARELLVKLESTNI-HSFN-NFNLRIGINVGPVVAGVIGSDKPHYDIWG 947

  Fly  1017 DTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWL 1072
            ::||.||||:|.|.|.:|.::.:.|..|:.|  ||..|.||.:|:||||.:.|::|
Worm   948 NSVNVASRMDSGGVAGRIQVTEEVKSILEPL--GYNFECRGQINVKGKGMMETFFL 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	32/182 (18%)
		HNOBA	<835..881	CDD:285003	9/49 (18%)
		CYCc	860..1052	CDD:214485	68/208 (33%)
		Guanylate_cyc	887..1074	CDD:278633	72/199 (36%)
acy-4	NP_504486.4	AC_N	<50..291	CDD:292831
		CYCc	260..451	CDD:214485
		Guanylate_cyc	293..448	CDD:278633
		CYCc	778..984	CDD:214485	70/228 (31%)
		Guanylate_cyc	807..1003	CDD:278633	72/199 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810