Protein Alignment CG42637 and gcy-18

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_502449.2
• Gene: gcy-18 / 178237
• WormBaseID: WBGene00001543
• Length: 1113
• Species: Caenorhabditis elegans
• Alignment Length: 1165
• Identity: 340/1165 - (29%)
• Similarity: 556/1165 - (47%)
• Gaps: 233/1165 - (20%)

  Fly    22 HRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGD----TVL 82
            |:.|:.:|::.|:        |:..:.|..:   .::|: ||:....:        ||    .::
 Worm    49 HKRVIKIGHIGAV--------GVMPNDARIL---NISKE-NLIEEGLV--------GDDIEFEIV 93

  Fly    83 ATKAITEMICDGIA------------TIFGPEGPCYVEAIVSQSR--NIPMISYKCAEYRASAIP 133
            :.:|.:|.. :|:|            ...||.....:||:...:.  |||:|||       |::|
 Worm    94 SRQACSESF-EGVAVAAELYHVHQVRAFIGPYCAAELEAVTKMATFWNIPIISY-------SSVP 150

  Fly   134 ----------TFARTEPPDT-QVVKSLLALLRYYAWNKFSI-------LYEDVWSPVADLLKDQA 180
                      |.||....:| .:.::.:|||.:|.|.|.:|       .:|.|     .:.::..
 Worm   151 NAVSDRSVYKTLARVSSKNTNSIAEATVALLLHYKWLKVAIATNTGSTAFERV-----SIFEEIM 210

  Fly   181 TKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMET 245
            .:..:||..|..| |......|.|    .||....|..|.  |..|.:|........:||.:..|
 Worm   211 HREGVTIVKKVMF-DENTDANEMM----NSGQLGDLAANA--RIIICLFSSTKELSKEFMQATYT 268

  Fly   246 AGLFARGEYMVIF-------VDMMVYSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLVVAS 303
            ..: ...||..|.       .|:..:...:.|...|..|.   .:|....::.|....|  ||:|
 Worm   269 MRM-NNAEYAYIIPWLQSGTKDLTPWIGADGEMLQRVKDH---YANAIIVDDVNGFDDS--VVSS 327

  Fly   304 TPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREE 368
                     |.::::|:..:.. ::::      :|.:.::     :|:||:||||.|:.|:|.|
 Worm   328 ---------FVEKIEKHGMQKS-DIDV------TNINGYL-----HLFDSLKLYALAIRKVLNE- 370

  Fly   369 TRVLTDDVIFEVASNGTRVIDTI--IKNRTYMSITGSK----------IKIDQYGDSEGNFSVLA 421
                ||:..:  .:||..:.:.:  :|....:|.:.|:          :.:|...|....||...
 Worm   371 ----TDNEAY--VTNGQFIWNRMRRMKFEGVVSRSSSEENKDAGAIGTVLMDDVADRAPIFSAFY 429

  Fly   422 YKPH--KWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLING-------------------SIDWPS 465
            ..|:  |.....||                   |.:||:.                   |..|||
 Worm   430 ISPNRDKVMKMVNM-------------------ESELISNCDGLKNKSGCFQLKINDIKSGFWPS 475

  Fly   466 -GGEKPADEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWK 529
             .|..|.|||:||:..:.|.     |...::...|.:||....|:...::|..: ..::|.:.|:
 Worm   476 EDGSMPLDEPICGYRGQRCS-----YLLEISVGSLIILLILISVVFFFLFRYCE-NKQLEKMPWR 534

  Fly   530 IDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKE----LKFPRKRD 590
            |..:::      :.:......|:||..|..::.:|   ..||:.:.|::.:..    .::.::|.
 Worm   535 IFHDDL------QFIDEEQVKSMMSVGSVTTKLSN---IQTGQKQHAIIGVNTHTTYHRYKQRRP 590

  Fly   591 ISREIMKEMRLLRELR---HDNINSFIGASV-EPTRILLVTDYCAKGSLYDIIENEDIKLDDLFI 651
            | :.|.::|:||.:::   |||:|.|:||:. |...:|::..:|::|::.|||.|.::.||:.|.
 Worm   591 I-KFIKEDMQLLTQMKQAVHDNLNPFLGAAFNEKEEMLVLWKFCSRGTIQDIIYNANVVLDEKFH 654

  Fly   652 ASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLH------------ELRQCAE 704
            .:.:.|:..|:.|:|.|.:.|||:|....|::...||::::|:|:.            |:....:
 Worm   655 GAFVRDITLGLEYLHASPIGYHGSLTPWCCLIDRNWMVKLSDYGIANPLERWEKQGAIEIAAAKD 719

  Fly   705 NESIGEHQHYRNQLWRAPELLRNH----------------IHGSQKGDVYAFAIIMYEIFSRKGP 753
            ::...:.....:.::.|||||:|.                :...|.||:|:|.::||||..|..|
 Worm   720 SDDKSQASQATSIIYMAPELLKNRETNKRRGMDQSWVKQSMLRRQAGDIYSFGMVMYEILFRSLP 784

  Fly   754 FGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIR 818
            | :.|....|:|||:    ..|.....||:::.:...  || :.|.:||||:|:||.||  |:.|
 Worm   785 F-RDNTNISELVDYL----ADGSKTVSPEIQNQMGLH--PD-LNALLRDCWSENPEIRP--SIRR 839

  Fly   819 NRLKKMRGGKTK-NIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLT 882
            .||......||| :::||||:|||:||||||.:|.|||.:|.|..::.:.||.::||..||.:|.
 Worm   840 VRLNTEMVLKTKGSLVDQMMKMMEQYANNLEKLVAERTGMLEEANIRADQLLTQLLPAYVANELK 904

  Fly   883 MGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAY 947
            ||:.|.|..|...||.||||||||.:.:.||||:|||.||.|||.||..|.....||||||||||
 Worm   905 MGRSVAPKLYSSATILFSDIVGFTTICSGSTPLEVVNMLNGLYTGFDECITRNKSYKVETIGDAY 969

  Fly   948 MVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRY 1012
            |||||:|.:|...|:..||:.||::...:..::|.|||...::.|.|.|||.|.|||||||.|||
 Worm   970 MVVSGIPEENEYNHSRNIANTALDMRQYLTGYQIPHRPTHRVRCRWGFHTGSVAAGVVGLTCPRY 1034

  Fly  1013 CLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWL 1072
            ||||||||.:|||||.|....|.:|.:..:.:......:.|.:||.|.:||||...|:||
 Worm  1035 CLFGDTVNVSSRMESTGTPGMIQMSEEAHMHIRAHHPVFTTTERGEVQVKGKGTCRTFWL 1094

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	97/475 (20%)
		PK_GC-A_B	543..827	CDD:270944	89/319 (28%)
		HNOBA	<833..881	CDD:462234	25/47 (53%)
		CYCc	860..1052	CDD:214485	96/191 (50%)
gcy-18	NP_502449.2	PBP1_NPR_GC-like	64..446	CDD:380575	95/466 (20%)
		Protein Kinases, catalytic domain	549..846	CDD:473864	89/310 (29%)
		CYCc	882..1073	CDD:214485	96/190 (51%)