DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and gcy-8

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_501324.2	Gene:	gcy-8 / 177584	WormBaseID:	WBGene00001535	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	1164	Identity:	350/1164 - (30%)
Similarity:	545/1164 - (46%)	Gaps:	230/1164 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 SNHRTVLTVGY---LTALTGDLK----TRQGLAISGALTMALDEVNKDPNLLPNVYLDLRWNDTK 77
            |..|..||:|:   :.||..|:|    :.:.|...|.|
Worm    63 SKGRIRLTIGHIGAIGALRNDVKILEVSHKALQAEGIL--------------------------- 100

  Fly    78 GDTVLATKAITEMIC----DGIA------------TIFGPEGPCYVEAIVSQSR--NIPMISYKC 124
             |..|..:.|::..|    :|:|            ...||.....::|:...:.  |||:|.|..
Worm   101 -DDDLDVEIISQTGCGESYEGVAVAADMYHLQKVKAFIGPYCNAEMDAVARMAAFWNIPIIGYMA 164

  Fly   125 AEYR---ASAIPTFARTEPPDT-QVVKSLLALLRYYAWNKFSIL-------YEDVWSPVADLLKD 178
            |...   .:|.||.||.....| .:.::..|:||:|.|||.:|:       |:.|.|     .::
Worm   165 ASNNLADKNAYPTLARISLRTTNSIAEATCAMLRHYGWNKVAIITNTGILAYDRVLS-----FEE 224

  Fly   179 QATKRNMTINHK---QSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYV--FLGAANSLVD 238
            ...:|.:.:..|   ..|.|::....        ||    |:.:..|..||.|  |.....|..:
Worm   225 VFHQRGINVVKKIMFDEFADSKAMIA--------SG----LLNDIKNSARIVVCLFSNTRESSRE 277

  Fly   239 FMSSMETAGLFARGEYMVIFVDMMVYSEREAEKY-------LRRVDQITFMSNCHSTENFNQMAR 296
            |:::..|.|:.. .||..:| ..:....::|..:       |::|.              :|.|.
Worm   278 FLTAANTQGMNV-NEYGYVF-PWLQDGGKDASPWTGADGSMLQKVK--------------DQYAN 326

  Fly   297 SLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYA-AYLYDSVKLYAWA 360
            ::::       .|...|...:     ..||...|..:.:........:||. .||:|::||||.|
Worm   327 AIII-------DDVNSFDNTI-----VGPFIERIKDVGLTEADVDIANIYGYLYLFDALKLYAIA 379

  Fly   361 VDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGS------KIKIDQYGDSEGNFSV 419
            ..|:|.|..:.       |...|| |::...::...::.:.|:      ::.:|...:....:..
Worm   380 ARKVLNETGKA-------ENLLNG-RMMWQNMRKLKFVGMVGASGIASGQVSMDDRAERAPLYRG 436

  Fly   420 LAYKPHKWNNSNNMPCNYHMVPVAYFH-QGEEHPE--YKLINGSI---DWPSGGEK-PADEPMCG 477
            ....|    ||:::....||.|....: .|..:..  |:::...|   .|||...| |.|||.||
Worm   437 FFVSP----NSDSVLPMVHMEPTMLDNCDGIANKSGCYEIVVTDIMRDFWPSVDRKMPKDEPDCG 497

  Fly   478 FANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGL-----------LWKID 531
            :.||.|     .||..:....| :|||.  |..:|.:...|| ||...|           |..||
Worm   498 YRNERC-----DYTLIIIGAAL-ILLFI--VAAVSAFFAQKI-LEKRALDKLPFRIYRDDLQFID 553

  Fly   532 PNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDI--SRE 594
            ..::|     .::|..|..:.||..:||||  |..:..|.  ..|:..    |:.::|.|  :|.
Worm   554 EEQLK-----SMLSLGSTRTKMSNMNYGSR--NHAIVGTN--THAIYH----KYVQRRPIVFNRA 605

  Fly   595 IMKEMRLLRELRHDNINSFIG-ASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDL 658
            ....::|::...|||||.|:| ...|...:|||..:|::|:|.|||.||.|:||..|..:.|.|:
Worm   606 DKTLIQLMKAAVHDNINPFLGMVWNEREEMLLVWKFCSRGTLQDIIYNESIQLDTKFHGAFIRDI 670

  Fly   659 IKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHE-LRQCAENESIG-------EHQHYR 715
            :.|:.|:|.||:.|||:|...:|::...||:::||:|:.: |.:..:::||.       :.:...
Worm   671 LAGLEYLHASQIGYHGSLTPWSCLIDRNWMIKLTDYGIADPLERWEKSQSISRDGLTSDDDKSQA 735

  Fly   716 NQ----LWRAPELLRNHIHG----------------SQKGDVYAFAIIMYEIFSRKGPFGQINFE 760
            .|    |:.:||:|:|....                .|.||||||.::||||..|..||.: ...
Worm   736 TQATSILYESPEMLKNREKNRVRRVDQDWMRQTQTRRQLGDVYAFGLVMYEIIFRALPFPE-GTN 799

  Fly   761 PKEIVDYVKKLPLKGEDPFRPEV--ESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLK- 822
            ..|:|::::    .|....:|.:  ..::..:     :.|.|:|||...||.||....|:..::
Worm   800 QSELVEWLR----DGSKVVKPTIPQNKVLNMD-----LSALIQDCWNTTPEMRPSLRRIKLNVET 855

  Fly   823 --KMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQ 885
              .::|    :::|||..|||:||||||.:|.|||.:|.|...:.:.||.::||..||.:|.:|:
Worm   856 YLNIKG----SLVDQMTRMMEQYANNLEKLVAERTGMLEEANQRADRLLSQLLPAYVANELKLGR 916

  Fly   886 GVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVV 950
            .|.|.::...|:.||||||||.|...::||:||..||.::..||:.|...|.|||||||||||||
Worm   917 PVPPKTFTSSTVLFSDIVGFTEMCQNASPLEVVAVLNGIFDGFDQFIARKDAYKVETIGDAYMVV 981

  Fly   951 SGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLF 1015
            ||:|.:||.||..||||:||::...:.:..:.|:.:..::.|:|.|||||.|.||||..||||||
Worm   982 SGVPEENGHRHINEIASIALDVHKFLSEFIVPHKRDTKVQCRLGFHTGPVAAAVVGLNAPRYCLF 1046

  Fly  1016 GDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            |||||.|||||||.|..|..||...|..|.|....||.|:||.:.:||||..:|:||.|
Worm  1047 GDTVNMASRMESNSEPGKTQISETAKNLLLKEYPDYICEQRGEIPIKGKGLCMTYWLMG 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	96/473 (20%)
		ANF_receptor	48..412	CDD:279440	82/411 (20%)
		PK_GC-A_B	543..827	CDD:270944	93/319 (29%)
		HNOBA	<835..881	CDD:285003	23/45 (51%)
		CYCc	860..1052	CDD:214485	95/191 (50%)
		Guanylate_cyc	887..1074	CDD:278633	98/186 (53%)
gcy-8	NP_501324.2	ANF_receptor	87..442	CDD:279440	84/439 (19%)
		Periplasmic_Binding_Protein_Type_1	94..434	CDD:299141	83/420 (20%)
		PKc_like	558..850	CDD:304357	93/314 (30%)
		HNOBA	<866..912	CDD:285003	23/45 (51%)
		CYCc	891..1084	CDD:214485	96/192 (50%)
		Guanylate_cyc	918..1105	CDD:278633	98/186 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810