Protein Alignment CG42637 and acy-3

DIOPT Version :9

• Sequence 1: NP_001007096.1
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_497765.4
• Gene: acy-3 / 175489
• WormBaseID: WBGene00000070
• Length: 1243
• Species: Caenorhabditis elegans
• Alignment Length: 1314
• Identity: 249/1314 - (18%)
• Similarity: 443/1314 - (33%)
• Gaps: 423/1314 - (32%)

  Fly   336 ESNFSKFISIYAAYLYDSVKLYAWAVDKMLRE--------------ETRVLTDDVIFEVASNGTR 386
            ||.|...:::::.|.:.|:..||......|..              .|..|...::..:.:|.|.
 Worm    95 ESLFPALLAVFSLYTFFSLPFYAILATSTLISIVQTCSFLLFVEPLHTNELLAIIVVHIWTNFTG 159

  Fly   387 V-----IDTIIKNRTYMSITGSKIKIDQYGDSEGN-------------------FSVLAYKPHKW 427
            :     .|.:.:| .::|...|. :.:...:.:.|                   ..:..||||.:
 Worm   160 IYLCSTADRLARN-AFLSARNSS-EAESTAEFQSNRLNKLLSSFLPYHLINQARHQITLYKPHLY 222

  Fly   428 NNSNNMPCNYHMVPVAYFHQGEEHPEYKLIN--------GSIDWPSGGEKPADEPMCGFANELCK 484
            |.:      |..|.|||         .:|:.        .|||                |..:.|
 Worm   223 NET------YSQVSVAY---------GRLVGFESVLAQCSSID----------------AARVLK 256

  Fly   485 KDDTHYTSTVAA------VVLGVLLFCS--GVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGN 541
            :.|:......|:      ...|:...||  |:.:....:..:..:|:|.|:     |..:..:|.
 Worm   257 ELDSRIERLAASNGCTRVASEGITAVCSIPGIDSQHATKLCRFSMELETLI-----NSFRDATGA 316

  Fly   542 E------IVSSP--------------------SKVSLMSAQS-----YGSRWTNQFVTSTG---- 571
            :      |.|.|                    ....||.:.:     |.|..|.:|:.|||
 Worm   317 DVSVCIGIDSGPVTAGVVGVSKWHYDVIGSVFDNALLMQSNATEPGVYVSNETRRFLGSTGEFEL 381

  Fly   572 -------RLRGAVVRIKELKFPRKRDISREIMKEM--RLLRELRHDNINSFIGASVEPTRILLVT 627
                   :|.|.:.. .|| ||..:..|...:.:.  |:|:.:          .::.||...:.|
 Worm   382 EKCPIGWKLYGHLPS-PEL-FPVNKRFSLVTVPQAVNRVLQSI----------VAMNPTLKTMGT 434

  Fly   628 DYCAKG----SLYDI----IENEDI-------------------KLDDLFIASLIHDLIKGMIYI 665
            :...||    ..:|:    :|:..|                   :.|..||.||...:...::|.
 Worm   435 NKKRKGEKSQEKFDMQKKKVEHSTIISTLSQRFRNPGLEAEYHKETDHWFIPSLAISIFFLVVYG 499

  Fly   666 HNSQLVYHGNLKSSNCVVTS-------RWMLQVTDFGLHELRQCAENESIGEHQHYRNQLW---- 719
            ....||....:.|...:|.:       ..||.:..|  |...|.....|.|   |..:.:.
 Worm   500 IYHMLVMPRLITSLALIVGALTVMFFILLMLYIDYF--HTFSQFITRTSAG---HAVSIILIIVI 559

  Fly   720 ---------------RAPELLRNHIHGSQKGDVYAFAI--IMYEIFSRKGPFGQINFEPKEIVD- 766
                           .||::.:. .|.|    .|:||:  |...:|.|   |..:......|:.
 Worm   560 LFVCGIVNTFSCPQPNAPDVCQK-AHFS----TYSFAMWTITTAVFVR---FPSVYLAILLIISL 616

  Fly   767 --YVKKLPLKGEDPFRPEVESIIEAE-SCPDYVLACI-------RDCWAEDPEERPEFSVIR-NR 820
              |..::.:...|.|.|. |.:.|.: ||  ::::.:       |.|      ||    ::| :.
 Worm   617 LTYGLQIYVTRPDEFGPR-EFMTELDLSC--FLISLVSMVFLHSRRC------ER----LLRLDF 668

  Fly   821 LKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQ 885
            |..::|.:..::.|:::.:     ||                    .:|..::|..||..:....
 Worm   669 LAVVKGIEETSMKDKLINL-----NN--------------------QMLLNLVPAHVAPGVIQKA 708

  Fly   886 G-VEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGY-DVYKVETIGDAYM 948
            | |...|:..|.|.:..:.||. :..|:.    :|.||.:::.||:.|..| .|.||::....|:
 Worm   709 GDVWHHSHQSVGIAYIAVSGFD-LEGEAG----INGLNYVFSHFDQAIANYKGVEKVKSANRFYI 768

  Fly   949 VVSGL------PIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGL 1007
            |..||      .:.......||:.|.....:.::.|..:   .|| ..::||:..|..:|.|...
 Worm   769 VAVGLLPDAAQNVNETPWTIGELMSTLAHFIISISQFAM---ENE-FHVQIGVDCGSTLAFVANT 829

  Fly  1008 TMPRYCLFGDTVN-TASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWW 1071
            ..|||.:||:|:: :.:.|::.|....: :|.:..|||
 Worm   830 DQPRYEIFGETLDRSRTLMQAAGHDTTL-VSEEVFLAL--------------------------- 866

  Fly  1072 LTGANENAIQKKLVDMMDMPPPL-FSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDG 1135
                              .|.|| |            |.||...||:.
 Worm   867 ------------------RPRPLRF------------SSQPVKVAMNL----------------- 884

  Fly  1136 ESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFVGGALLESAQAS--LSTLNHSETNETNC 1198
             :.|.|...:|:....:....|:.:.....|:....|...:.:...|.|  .|::..|.::|..
 Worm   885 -NAYELVTGLRDVSVDIPTMPREEQERHTQGMVEAQFANQSRMYDTQTSEMASSMASSFSSELR- 947

  Fly  1199 DMDGGSGGVSGSGSGLVRQPNALHKPLAMVRPHRIISAAQLPQLGDNDDDSADTLLRE--SRSLD 1261
            .:||.:  .:.|....:....||.|.....|.||.:       |.::|.|.    .||  .|::.
 Worm   948 SIDGDA--ETDSDLEWITPETALMKDPQPQRSHRFV-------LKNSDYDP----YREPVHRNIR 999

  Fly  1262 PMPMQQLRKRHDRVKL----------PPSKLSKNNSRSLDTGVSLISGNP--NG-----EVHSSQ 1309
            .|..:| ..|:.|::.          .||....|:..|...|....|.|.  ||     :.||
 Worm  1000 AMSAEQ-DYRNRRIQSGSDMSDAECGGPSTSRANSRNSYRRGWRPSSKNSLRNGFGLFRKGHS-- 1061

  Fly  1310 LDLDNEMTANPVDATDGYDDELGLLMRH-----DNGQLPALRYSGSFPNAQISIVPTGRSAGGGG 1369
               |||.:.:.:|..:...:.:..:::.     |..::..|.|. .||....|:....|:.
 Worm  1062 ---DNEQSVDGIDKIEAAANRVDRMIQELNAFGDFAEIKPLEYQ-PFPANFGSVKSIHRAM---- 1118

  Fly  1370 GGREGGGSNCAKHLNNNCNGGV--NVEDDLESPLLQRQASLSVPPEEMLAHNKRWHSLEHMDGPG 1432
                  .|.|....:|..:..|  :||.:..| :.|.:.|.| ..:......:|||. :..||..
 Worm  1119 ------SSACHTEYDNAESDAVISDVESNANS-ISQLRNSKS-RQKRRWKEARRWHR-DAADGDT 1174

  Fly  1433 GHGGNSVSYAADID 1446
            ....:|::.:.|:|
 Worm  1175 ESQCSSMAGSIDLD 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	26/146 (18%)
		ANF_receptor	48..412	CDD:279440	16/94 (17%)
		PK_GC-A_B	543..827	CDD:270944	73/388 (19%)
		HNOBA	<835..881	CDD:285003	6/45 (13%)
		CYCc	860..1052	CDD:214485	49/200 (25%)
		Guanylate_cyc	887..1074	CDD:278633	44/194 (23%)
acy-3	NP_497765.4	TctB	26..137	CDD:284693	8/41 (20%)
		CYCc	195..378	CDD:214485	38/218 (17%)
		Nucleotidyl_cyc_III	221..382	CDD:299850	35/196 (18%)
		CYCc	696..873	CDD:214485	51/231 (22%)
		Nucleotidyl_cyc_III	711..880	CDD:299850	51/235 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900