Protein Alignment CG42637 and gcy-12

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_494995.2
• Gene: gcy-12 / 173902
• WormBaseID: WBGene00001538
• Length: 1679
• Species: Caenorhabditis elegans
• Alignment Length: 1648
• Identity: 537/1648 - (32%)
• Similarity: 784/1648 - (47%)
• Gaps: 336/1648 - (20%)

  Fly    46 ISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPCYVEAI 110
            :||||..|:.|:|:|.:|:|...|...:.:|.|:...:|:...|....|.....|||..|..||.
 Worm   141 VSGALVAAIVEINQDKDLIPAYQLKYVFGNTCGNDSHSTRLFMEHWQAGARVFIGPEKNCKTEAA 205

  Fly   111 VSQSRNIPMISYKCAE---------YRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYE 166
            ::.|:|:|:|||:|.:         ||     |||||.||..::.|:.::|::.|.|.|||::|:
 Worm   206 MAASQNLPIISYRCNDQDISRDDYHYR-----TFARTVPPAGEIFKAFMSLMKQYNWRKFSVVYD 265

  Fly   167 ----DVWSPVADLLKDQATKRNMTINHK----------------------QSFIDNRVKCCEQML 205
                .|.:.:.:.||......|....||                      || |:|.:|
 Worm   266 VKKGQVKNELFETLKRMVETENKFEEHKFEIMNVSKLEFSKMDISSQQDIQS-IENAIK------ 323

  Fly   206 DCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVD-----MMVYS 265
                         :||..||||:...........:|.|...|| .:.:||:|:||     :.||.
 Worm   324 -------------STMQTTRIYLTFDNVRLFRTMLSIMGEMGL-TQQDYMLIYVDTNYDWLNVYH 374

  Fly   266 EREAEKYLRRVDQITFM-----SNCHSTENFNQMARSLLVVASTP---PTKDYIQFTKQVQKY-- 320
            ... ..:||  :.:|::     :|..|.......|||.|.:..||   .::.:..|.|:...|
 Worm   375 SMN-NHFLR--NTMTYLHHSWDANNSSDRKMLDYARSALSIIPTPVKLNSQRFYNFWKKAGDYMH 436

  Fly   321 --SSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASN 383
              ..:...||:..|:             |.||||:|.|||.|:.:::.|    ..:|..::..::
 Worm   437 HFGVQKADNLKGNRI-------------ACYLYDAVYLYAKAIHELVEE----YGNDDSYDPTAD 484

  Fly   384 GTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKP-----HKWNNSNNMPCNYHMVPVA 443
            |..:||.|: |:.|.||.|..::||:.|:|:||||:|:::.     :| ::.:..|.::.:...|
 Worm   485 GKAIIDRIV-NKKYRSIQGFDMRIDERGNSKGNFSLLSWQKVAPIMNK-SDPSYYPLDHALDLTA 547

  Fly   444 YFHQGEEH---PEYKLINGSIDWPSGGEKPADEPMCGFANELC-KKDDTHYTSTVAAVVLGVLLF 504
            .|.:..:.   |..:..:..|.|.. ||.|.|||:|||..|.| ||....|.:.|..:::.|...
 Worm   548 IFVEAPDKDRLPNLQFKSSRIQWLK-GEPPPDEPVCGFHGENCRKKGIFSYLTVVVMILIAVFSL 611

  Fly   505 CSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMS------AQSYGSRWT 563
            .....|::..|..:.|.|: .::|||||.|::...|.  |::.|..|||.      |::....|:
 Worm   612 VLTGFTLNYIRSRRFEKEL-SMIWKIDPYEVRRVVGG--VNNESTASLMQSDVMQFAKTKTPWWS 673

  Fly   564 NQFVTSTG-----RLRGAVVRIKELKFPRK-RDISREIMKEMRLLRELRHDNINSFIGASVEPTR 622
            ...|..||     ..:|.:|.:|:|.:.|| :|::||..||:|.:|:|.|.|:|:|:|..|....
 Worm   674 KAPVQGTGMRGLASYKGTLVGLKDLMYGRKPKDLTREAKKELRAMRQLAHPNVNNFLGIIVCQYS 738

  Fly   623 ILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRW 687
            :.:|.:||:||||:||:.||::|||.:::||.:.||:|||:|||:|:|..||||||:||::||||
 Worm   739 VTVVREYCSKGSLHDILRNENLKLDHMYVASFVDDLVKGMVYIHDSELKMHGNLKSTNCLITSRW 803

  Fly   688 MLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGS--------QKGDVYAFAIIM 744
            .||:.||||.|||:....:|  .:..:.|.||.|||.:.  |:||        .|.|.|:|.||.
 Worm   804 TLQIADFGLRELREGIMYDS--SYNIWENFLWTAPEAMT--INGSLAISNPPTPKADAYSFGIIF 864

  Fly   745 YEIFSRKGPF------GQINFEPKEIVDYV-------KKLPLKGEDP-FRPEVESIIEAESCPDY 795
            :|||:|:||:      |.:|.|.....|.|       |.:.....|| |||:. |.:|.:   :|
 Worm   865 HEIFTREGPYKIYVQRGDVNGEAAPKKDSVECRALVEKTVRRVYSDPYFRPDT-SDLEVQ---NY 925

  Fly   796 VLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTK-NIMDQMMEMMEKYANNLEDIVTERTRLLC 859
            |...:..||..||.:||||..|:|:||.:.....| ||||.|:.|||||...|||:|.|||..|.
 Worm   926 VKEVMAACWHHDPYQRPEFKTIKNKLKPLFHQIYKQNIMDHMVLMMEKYQTQLEDLVDERTIELK 990

  Fly   860 EEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDL 924
            :|:.:::.||.||||.||||:|..||.|.|.::..||||||||||||.:|.||||::||.|||.|
 Worm   991 DEQRRSQHLLQRMLPSSVAEQLLAGQDVIPEAFPPVTIYFSDIVGFTTISGESTPMEVVTFLNKL 1055

  Fly   925 YTVFDRIIRGYDVYKVETIGDAYMVVSGLP-IKNGDRHAGEIASMALELLHAVKQHRIAHRPNET 988
            ||:||.|||.||||||||||||||||||:| .|..:.||.:||.||:.:|.||:...|.||..|.
 Worm  1056 YTLFDSIIRRYDVYKVETIGDAYMVVSGVPQYKTMEYHAEQIAMMAIHILSAVRSFSIPHRSCEP 1120

  Fly   989 LKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYIT 1053
            |.:||||||||.||||||.|||||.|||||||||||||||||||:||.|:..:..|..:..|::.
 Worm  1121 LMIRIGMHTGPCVAGVVGKTMPRYTLFGDTVNTASRMESNGEALRIHCSSSTQKVLTSIDQGFLL 1185

  Fly  1054 EKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPR-----KSPKLNPDS----- 1108
            |:||.:.:||||.:.|:||.|.......:.:.|.| :.|.:|.||.     .|..:|.:|
 Worm  1186 EERGSLAIKGKGQMTTYWLNGRAGYEFTETIEDKM-VVPDIFPRPNLKNRGSSWGVNRESSLSLA 1249

  Fly  1109 RQPSIQAMHFCGTGSRRQSTVPRAMDGESTY-----------SLQGSVRESPRMVSKRDRDRERP 1162
            .:.|.|.|       :|||......:.:..|           |...|.||.|::.   :.|||
 Worm  1250 TEKSSQIM-------KRQSAAMNRNNQDVIYYNQPLNSGGFTSRGTSNREMPKLY---EEDRE-- 1302

  Fly  1163 PINGLGAGHFVGGALLESAQASLSTLNHSETNETNCDMDGGSGG------VSGSGSGLVRQPNAL 1221
                         :||..:.:.|.:........|....:|.|..      :|.:.|....:|:..
 Worm  1303 -------------SLLNQSASLLGSRTSGRKKSTASKYNGFSASRMFSSTISNASSSRPSRPSTF 1354

  Fly  1222 -HKPLAMVRPHRIISAAQLPQLGD---------------------NDDDSADTLLRESRSLDPMP 1264
             |..||:.:     .:..||. |:                     |:..|.:.:.|::..:|...
 Worm  1355 DHDTLALRK-----RSTSLPD-GEKLNLEFIETTNLANNSVPAIPNNISSLEPVFRKASIIDGYS 1413

  Fly  1265 MQ-------------------QLRKRHDRVKLP------------PSKLSKNN-SRSLDTGVSLI 1297
            .|                   ..|||......|            |.|:::|. |.|:.|.||
 Worm  1414 SQSESPSQSQYPSYRDLTTGPHQRKRGIATVFPVRKRSLSCGDAVPLKINENGASGSITTAVS-- 1476

  Fly  1298 SGNPNGEVHSSQLDLDNEM-----TANPVDATDGYDDELGLLMRHDNGQLPALRYSGSFPNAQIS 1357
                   ..||...||..|     .::|.:.....|||..|:   ||..|
 Worm  1477 -------PRSSCRALDPTMKLAARASSPDEIIFQEDDEDALI---DNDSL--------------- 1516

  Fly  1358 IVPTGRSAGGGGGGREGGGSNCAKHLNNNCNGGVNVEDDLESPLLQ--RQASLSVPPEEMLAHNK 1420
                  ....|....|.....|.:....|.:..:..    .|||.:  |.||.....:.....||
 Worm  1517 ------LTSNGNSKSEDVLRTCPQPRRKNKHSFLRD----PSPLAKRFRDASPFGKKKPFWNSNK 1571

  Fly  1421 RWHSLEHMDGPGG---------HGGNSVSYAADIDNRHPGDLDFFSGSSNQHHRSKAAGGSKLTN 1476
               |.||...|..         .||:...||   |..|..|.:..||.:|.:...:.   .|:|.
 Worm  1572 ---SNEHTSSPADSISRLFRRFRGGSVNEYA---DLNHYCDDEDESGRANGYEMQEM---GKMTG 1627

  Fly  1477 WMTNIFKGNGVRSGEARRVGILP 1499
            ....  :.||.|:.  |.|...|
 Worm  1628 RQRE--QRNGSRTN--RSVSCSP 1646

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	124/455 (27%)
		PK_GC-A_B	543..827	CDD:270944	126/317 (40%)
		HNOBA	<833..881	CDD:462234	27/47 (57%)
		CYCc	860..1052	CDD:214485	123/192 (64%)
gcy-12	NP_494995.2	Periplasmic_Binding_Protein_type1	140..527	CDD:471960	121/432 (28%)
		PK_GC-A_B	648..957	CDD:270944	126/316 (40%)
		CYCc	991..1183	CDD:214485	122/191 (64%)