DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and gcy-35

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001252131.1	Gene:	gcy-35 / 173202	WormBaseID:	WBGene00001555	Length:	688	Species:	Caenorhabditis elegans

Alignment Length:	694	Identity:	184/694 - (26%)
Similarity:	286/694 - (41%)	Gaps:	214/694 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   585 FPRKRDISREIMKE------MRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENED 643
            :|..:.:.||:.:.      :..::|.:.:::::|:...|    :.::|.          |||.:
Worm   144 YPIVKGVVREVARRIYDTEVVMKVQERKQEHLDAFVTEHV----VFVITQ----------IENAN 194

  Fly   644 --------IKLDDLFIASLIHDLIKGMIYIHNSQ----LVYH------------GNLKSSNCVVT 684
                    .|.|...      ||..|:..|.:|.    ..||            ||.........
Worm   195 STQPKSISSKADSQI------DLSTGIYEISSSDFSLAFPYHICFDPDLFVEHFGNFIKKTFPNA 253

  Fly   685 SRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFS 749
            .|...:|||  |.||.......|....::|:|.|:                           :|.
Worm   254 MRQETRVTD--LLELVHPEVPFSYESIKYYKNSLF---------------------------VFR 289

  Fly   750 RKGPFGQI----NFEPKEIVDYVKKLPLKGEDPFRPE--------------VESIIEAESCPDYV 796
            .|| .|.|    |.|.|.::       |||...|..|              |..:||
Worm   290 LKG-LGDIVHNANDEAKTVL-------LKGSMVFIDEGKYILYMCSVNVTTVRELIE-------- 338

  Fly   797 LACIRDCWAEDPEE----RPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRL 857
                |:....|.:.    |....:.::|:.::...:|   :::..:.::|.|..||
Worm   339 ----RNLHLSDMQRHDGTRDVIMLNQSRMSQVELNRT---LEETTKKLKKMAQELE--------- 387

  Fly   858 LCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLN 922
              .||.||::||..::|.|||:.|..|:.::...:...|:.|:|||.||.:.|..||..||..||
Worm   388 --IEKQKTDELLCELMPASVADSLRSGKAMDAKEFADCTLLFTDIVTFTNICAMCTPYDVVTLLN 450

  Fly   923 DLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVK--QHRIAHRP 985
            |||..|||::..:|.|||||||||||:|.|:| :..:.||..:.::::.:|...|  ...|.|:|
Worm   451 DLYLRFDRLVGLHDAYKVETIGDAYMIVGGVP-ERCENHAERVLNISIGMLMESKLVLSPITHKP 514

  Fly   986 NETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGG 1050
               :|:|:|:|.|||||||||:.||||||||||||.|::|||||...|||:|...||...|....
Worm   515 ---IKIRLGVHCGPVVAGVVGIKMPRYCLFGDTVNVANKMESNGIQCKIHVSETGKLNGLKANPS 576

  Fly  1051 YITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQA 1115
            |:...||...::|||.:.|::|...:..::.:           |.||||..
Worm   577 YVFIDRGNTEIRGKGMMYTYFLERNDRKSVWE-----------LCSRPRSG-------------- 616

  Fly  1116 MHFCGTGSRRQSTVPRAMD--GESTYSLQGSVRESPRMVSKRDRDRERPPINGLGAGHFVGGALL 1178
                      :.|:...|:  .:|.|..:|..:|:..:.            ||
Worm   617 ----------EQTIDGYMELHDQSIYQEEGGQQENLTVE------------NG------------ 647

  Fly  1179 ESAQASLSTLNHSETNETNCDMDGGSGGVSGS----GSGLVRQP 1218
            .|||.     ||:..|.|:   ..|...::||    ||..:|.|
Worm   648 NSAQN-----NHNNNNNTH---HSGRKLMNGSSVDPGSHHIRSP 683

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	52/293 (18%)
		HNOBA	<835..881	CDD:285003	14/45 (31%)
		CYCc	860..1052	CDD:214485	92/193 (48%)
		Guanylate_cyc	887..1074	CDD:278633	88/188 (47%)
gcy-35	NP_001252131.1	HNOB	3..167	CDD:285002	3/22 (14%)
		HNOBA	218..409	CDD:285003	52/253 (21%)
		CYCc	388..579	CDD:214485	93/194 (48%)
		Guanylate_cyc	415..599	CDD:278633	87/187 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910