Protein Alignment CG42637 and Gucy2e

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_036012232.1
• Gene: Gucy2e / 14919
• MGIID: 105123
• Length: 1139
• Species: Mus musculus
• Alignment Length: 1219
• Identity: 370/1219 - (30%)
• Similarity: 554/1219 - (45%)
• Gaps: 196/1219 - (16%)

  Fly     3 RWPFNLL--LLLSVAVRDCSNHRTVLTVGYLTALTGD---LKTRQGLAISGALTMALDEVNKD-- 60
            |||...|  |||.:.:...|....|..||.|.....|   .:.|..|    |..:|.:.:|:|
Mouse    32 RWPRPGLPGLLLLLLLPSPSALSAVFKVGVLGPWACDPIFARARPDL----AARLAANRLNRDFA 92

  Fly    61 ----PN----LLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGP--CYVEAIVSQSR 115
                |.    |||...|      |.|.....:.|::.     ::.:.||..|  |....:::|..
Mouse    93 LDGGPRFEVALLPEPCL------TPGSLGAVSSALSR-----VSGLVGPVNPAACRPAELLAQEA 146

  Fly   116 NIPMISYKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILY--EDVWSPVADLLKD 178
            .:.::.:.|...||:     ..|.|..|....:|..|||.:.|.:.:::.  :|:|......|..
Mouse   147 GVALVPWGCPGTRAA-----GTTAPAVTPAADALYVLLRAFRWARVALITAPQDLWVEAGRALST 206

  Fly   179 QATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTM-NRTRIYVFLGAANSLVDFMSS 242
            ....|.:.:....|...:......:.|...|.|   ..|:..: :|.|.. ::|.|.|    ...
Mouse   207 ALRARGLPVALVTSMETSDRSGAREALGRIRDG---PRVRGKLPSRVRAR-WVGPAES----GQR 263

  Fly   243 METAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITF---------MSNCH-----------S 287
            .|.|.:..|...:::.:..::....|....|...:::..         ....|           :
Mouse   264 SEPASVSVRSAVVIMVMHSVLLGGEEQRYLLEAAEELALTDGSLVFLPFDTLHYALSPGPEALAA 328

  Fly   288 TENFNQMARS----LLVVASTPPTKDYIQFTKQVQKYSSKP-PFNLEIPRLFVESNFSKFISIYA 347
            ..|.:|:.|:    |.:....||........::.|::...| ..||            |.:|...
Mouse   329 FVNSSQLRRAHDAVLTLTRRCPPGGSVQDSLRRAQEHQELPLDLNL------------KQVSPLF 381

  Fly   348 AYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG-----SKIKI 407
            ..:||:|.|.|..|     :..|..........||...:|.:..:..  :..:.|     |.:.:
Mouse   382 GTIYDAVFLLAGGV-----KRARTAVGGGWVSGASVARQVREAQVSG--FCGVLGRTEEPSFVLL 439

  Fly   408 DQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHMV-PVAYFHQGEEHPEYKLINGSIDWPSGGEKPA 471
            |.....|..|:.                  |:: ||....:....|        :.:|.||..|.
Mouse   440 DTDASGEQLFAT------------------HLLDPVLGSLRSAGTP--------MHFPRGGPAPG 478

  Fly   472 DEPMCGFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKW---------------KIEL 521
            .:|.|.|..::.......    ...|.:|.||.....:|.:....:               ||.|
Mouse   479 PDPSCWFDPDVICNGGVE----PGLVFVGFLLVIGMGLTGAFLAHYLRHRLLHMQMASGPNKIIL 539

  Fly   522 EIEGLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYGSRWTN-QFVTSTGRLRGAVVRIKELKF 585
            .:|.:.:...|.   |.|...:..|.|.::..||....|..:. |..|:.|...|..|.:|  ||
Mouse   540 TLEDVTFLHPPG---GSSRKVVQGSRSSLATRSASDIRSVPSQPQESTNVGLYEGDWVWLK--KF 599

  Fly   586 PRKRDIS-REIMK-EMRLLRELRHDNINSFIGASVEPTR----------ILLVTDYCAKGSLYDI 638
            |.:..:: |...| ....||||||:|:..::|..:..|.          :.:|:::||:|||:|:
Mouse   600 PGEHHMAIRPATKTAFSKLRELRHENVALYLGLFLAGTADSPATPGEGILAVVSEHCARGSLHDL 664

  Fly   639 IENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCA 703
            :...:||||.:|.:||:.||||||.|:|: :.|.||.|||.||||..|::|:|||.|...|.:.
Mouse   665 LAQREIKLDWMFKSSLLLDLIKGMRYLHH-RGVAHGRLKSRNCVVDGRFVLKVTDHGHGRLLEA- 727

  Fly   704 ENESIGEHQHYRNQLWRAPELLRN---HIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIV 765
             ...:.|.....:|||.||||||:   ...|:..|||::.||||.|:..|..|:..:...|:|::
Mouse   728 -QRVLPEPPSAEDQLWTAPELLRDPSLERRGTLAGDVFSLAIIMQEVVCRSTPYAMLELTPEEVI 791

  Fly   766 DYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTK 830
            ..|:..|        |....::..:..|...:..:..||||.||.||...:..:..|.:..|:..
Mouse   792 QRVRSPP--------PLCRPLVSMDQAPMECIQLMTQCWAEHPELRPSMDLTFDLFKSINKGRKT 848

  Fly   831 NIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLV 895
            ||:|.|:.|:|:|::||||::.|||..|.:||.||:.||.:|||.||||.|.||..|||..::.|
Mouse   849 NIIDSMLRMLEQYSSNLEDLIRERTEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEV 913

  Fly   896 TIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDR 960
            |:|||||||||.:||.|.|::||:.||||||:||.||..:||||||||||||||.||||.:||.|
Mouse   914 TLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGAHDVYKVETIGDAYMVASGLPQRNGQR 978

  Fly   961 HAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRM 1025
            ||.|||:|:|::|.||...|:.|.|...:::|||:|:||.|||||||||||||||||||||||||
Mouse   979 HAAEIANMSLDILSAVGSFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRM 1043

  Fly  1026 ESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDM 1090
            ||.|...:||::......|..|..|:..|.||...:||||...|:||.|...
Mouse  1044 ESTGLPYRIHVNMSTVRILRALDQGFQMECRGRTELKGKGIEDTYWLVGRLG------------- 1095

  Fly  1091 PPPLFSRP-RKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGEST 1138
                |::| .|.|.|.|.:....|.....   ...|:..:.:|..|:.|
Mouse  1096 ----FNKPIPKPPDLQPGASNHGISLQEI---PPERRKKLEKARPGQFT 1137

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	84/467 (18%)
		PK_GC-A_B	543..827	CDD:270944	100/299 (33%)
		HNOBA	<833..881	CDD:462234	26/47 (55%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
Gucy2e	XP_036012232.1	PBP1_sensory_GC_DEF-like	58..465	CDD:380594	84/471 (18%)
		PK_GC-2D	570..845	CDD:270945	97/287 (34%)
		HNOBA	<854..899	CDD:462234	25/44 (57%)
		CYCc	879..1070	CDD:214485	119/190 (63%)