DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and gucy2d

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	XP_005165318.1	Gene:	gucy2d / 140426	ZFINID:	ZDB-GENE-011128-9	Length:	1141	Species:	Danio rerio

Alignment Length:	1158	Identity:	368/1158 - (31%)
Similarity:	556/1158 - (48%)	Gaps:	196/1158 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRW--NDTKGDTVLATKAITEMICDGIATIF-GPEGP--CYVE 108
            |..:|:..:||||.|....:.|...  .|......||..|..|    |..:.| ||..|  |...
Zfish    99 AARLAMSRINKDPELNKGYWYDYTVINEDCSSSRGLARFAELE----GYGSAFLGPANPGYCTAA 159

  Fly   109 AIVSQSRNIPMISYKC--AEYRASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSILYE--DVW 169
            .:::::.|..::|:.|  ||......|||.|..|..::|   |.::||::.|....|:..  |:|
Zfish   160 TLLAKNWNKGILSWGCLKAEMDEEMYPTFLRPLPLSSRV---LFSVLRFFRWAHVGIVTAEGDMW 221

  Fly   170 SPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYV------ 228
            ......|........:.:        .:|...||..:..|..  .|.:::| :|.|:.:
Zfish   222 EATGHELAASLRALGLPV--------GKVVTMEQDKEGPRQA--LQAIRDT-DRVRVVIMCMHSA 275

  Fly   229 FLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYS-EREAEKY--------LRRV-DQITFMS 283
            .:|.........:::|.. :..|| |:.|..|.::|| ..|..||        |||. |.:..::
Zfish   276 LIGGEEQYQLLTTALEMR-MIDRG-YIFIPYDTLLYSLPYENVKYPILANDSKLRRAYDGVLTVT 338

  Fly   284 NCHSTEN----FNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFIS 344
            .....:|    ||....|..:..||.        .::|.::.|  ||               |.:
Zfish   339 MDQGEQNFYEAFNAAQESFEIRGSTS--------AEEVTRWVS--PF---------------FGT 378

  Fly   345 IYAAYLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVI--DTIIKNRTYMSITGSKIKI 407
            ||....|.:          |..|::|          ||:|.|.:  |.:.:|.......|...:|
Zfish   379 IYNMIYYTA----------MAAEQSR----------ASSGGRWVSGDLLSQNEGGFEFDGFNQRI 423

  Fly   408 D----------QYG--DSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGS 460
            .          :|.  ||:|:.|.| |:.|....|               |...::...|.:..|
Zfish   424 SGGTNGEGMQVRYAVLDSDGSGSSL-YRTHALEAS---------------HTYGKYGGLKYLGKS 472

  Fly   461 IDWPSGGEKPADEPMCGFANEL-CKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKW------- 517
            |.:  .|..|:.:..|.|:..: |.......|.....:...||:..:|::.:.: ||:
Zfish   473 IHF--AGASPSSDANCWFSPYIACSGGLDGVTLFFLLMFFIVLIAGAGILFLQV-RKYGAGGFFG 534

  Fly   518 ----------KIELEIEGLLWKIDPNEIKGYSGNEIVSSPSKVSL----MSAQSYGSRWTNQFVT 568
                      ||.|.::.|::.......:..:...::.|...|..    :|.:||        :|
Zfish   535 AFIGGGGSPTKIVLTLDDLVFINTTLSRRKLNDESMLKSQLDVKTPRHSVSGRSY--------IT 591

  Fly   569 STGRLRGAVVRIKELKFPRK-------RDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLV 626
            ||.......|...:..:.:|       .:||.........||::||:|:|.|:|..::.....:|
Zfish   592 STPETSNVAVFEGDWVWLKKCPCADSITEISESTQTIFVKLRDMRHENLNLFLGLFMDTGIFGIV 656

  Fly   627 TDYCAKGSLYDIIENEDIKLDDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQV 691
            |::|.:|||.|::.||:::||.:|.:||:.|||:||.|:||..:: ||.|||.||||..|::|:|
Zfish   657 TEHCTRGSLEDLLNNEEMRLDWMFKSSLLLDLIRGMKYLHNRGII-HGRLKSRNCVVDGRFVLKV 720

  Fly   692 TDFGLHELRQCAENESIGEHQHYRNQLWRAPELLRN---HIHGSQKGDVYAFAIIMYEIFSRKGP 753
            ||:|.:|:..|  ...|.|.....:|.|.|||:|||   ...|:..||||:|:|||.|:.||..|
Zfish   721 TDYGFNEILNC--QNIILEDNAPEDQFWTAPEILRNPDLKKKGTYPGDVYSFSIIMQEVISRCAP 783

  Fly   754 FGQINFEPKEIVDYVKKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIR 818
            |..::..|:||::.|:..|        |.....:..:..|..|:..::..|:|:||:||.|..|.
Zfish   784 FCMLDMPPEEIIEKVRSPP--------PLCRPTVSMDEAPLDVIQLMKQAWSEEPEQRPTFEDIF 840

  Fly   819 NRLKKMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTM 883
            .:.|.|..||..||:|.|:.|:|:|::||||::.|||..|..|:.||:.||.:|||:|||..|..
Zfish   841 RQFKSMNKGKKTNIIDSMLRMLEQYSSNLEDLIRERTEELEVERQKTDALLAQMLPKSVALALKT 905

  Fly   884 GQGVEPVSYDLVTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYM 948
            |:.|:|..:..||:|||||||||.:||.|.|::||:.||||||.||.||..:|||||||||||||
Zfish   906 GKPVKPEHFAEVTLYFSDIVGFTTISALSEPIEVVDLLNDLYTHFDGIIAIHDVYKVETIGDAYM 970

  Fly   949 VVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYC 1013
            |.||:|.:||.|||.|:|:|:|::||.:...::.|.|:..:|:|||:|:||||||||||.|||||
Zfish   971 VASGVPNRNGTRHAAEMANMSLDILHCIGTFKMRHMPDVKVKIRIGLHSGPVVAGVVGLKMPRYC 1035

  Fly  1014 LFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANEN 1078
            ||||||||||||||.|...:||::......|:.|..||..:.||...:||||...|:||.|.
Zfish  1036 LFGDTVNTASRMESTGLPYRIHVNQSTVDVLNSLKLGYKIDTRGRTELKGKGVEETFWLVGR--- 1097

  Fly  1079 AIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPR 1131
                   |..|.|.|:      .|.|.|.:....|.....  ...|||..:.|
Zfish  1098 -------DGFDKPLPI------PPDLTPGASNHGISLDEI--PTDRRQKFLDR 1135

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	96/438 (22%)
		ANF_receptor	48..412	CDD:279440	88/405 (22%)
		PK_GC-A_B	543..827	CDD:270944	101/297 (34%)
		HNOBA	<835..881	CDD:285003	23/45 (51%)
		CYCc	860..1052	CDD:214485	112/191 (59%)
		Guanylate_cyc	887..1074	CDD:278633	109/186 (59%)
gucy2d	XP_005165318.1	PBP1_sensory_GC_DEF_like	78..470	CDD:107366	98/451 (22%)
		PK_GC-2D	581..849	CDD:270945	99/286 (35%)
		HNOBA	<858..903	CDD:311573	23/44 (52%)
		CYCc	883..1075	CDD:214485	113/191 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920