DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and gucy2f

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_571939.2	Gene:	gucy2f / 140424	ZFINID:	ZDB-GENE-011128-7	Length:	1107	Species:	Danio rerio

Alignment Length:	1117	Identity:	365/1117 - (32%)
Similarity:	559/1117 - (50%)	Gaps:	185/1117 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 ALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMI-CDGIATIF-GPEGP--CYVEA 109
            |..:|:..:|.|.:|.....:|........:|   :||:|..: .:.:|..| ||..|  |...|
Zfish    80 ASRLAVGRINNDFSLDLGCTMDFVILQEACET---SKALTSFVQYENVADAFVGPTNPGYCNAAA 141

  Fly   110 IVSQSRNIPMISYKCAEY---RASAIPTFARTEPPDTQVVKSLLALLRYYAWNKFSIL--YEDVW 169
            ::|::.:..:.|:.|..:   |....||||||.|...:|   |..:|:::.|....|:  .||:|
Zfish   142 LMSKNWDKSLFSWACVNHELDRVQGYPTFARTLPSPLRV---LFNVLKFFRWANIGIVSSNEDIW 203

  Fly   170 SPVADLLKDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTM----NRTRIYVFL 230
            ...|..|......|.:.:....|..:|..                 :::||:    |...|.|.:
Zfish   204 IDTAAKLASALRNRGLPVGIVTSMGNNDT-----------------MLENTLMSIKNAGDIKVII 251

  Fly   231 GAANSLV-------DFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHST 288
            ...:|::       .|::.....|| |.|.|:.|..|.::||    ..|:    .||:    :..
Zfish   252 MCMHSVLIGGEQQATFLTKAYDMGL-ASGRYVFIPYDTLLYS----LPYI----NITY----YPL 303

  Fly   289 ENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNL--EIPRLFVESNFSKFISIYAAYLY 351
            :|.::::::...|.:.....|.:.|.:         .||.  ::..|.|.....:...::.. :|
Zfish   304 QNNSKLSKAYDAVLTITLDSDIMTFNE---------AFNAAKQLGELMVTQEPEQVSPLFGT-IY 358

  Fly   352 DSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITG--SKIKIDQYGDSE 414
            :|:.|.|.::.. .|...|.|          :||. :....:|.|:   ||  ..|:.|:.|:.:
Zfish   359 NSLYLLAKSMHN-ARRAGRWL----------SGTN-LAYFTRNITF---TGFNQDIQTDEQGNGQ 408

  Fly   415 GNFSVLAYKPHKWNNS------NNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADE 473
            .|:.:|  ....|...      .:|..:..:....:.|...|.|                 |..:
Zfish   409 TNYVIL--DTEAWGTQLYRCFLVDMTSDLVLFAGRFIHFPGESP-----------------PPSD 454

  Fly   474 PMCGFA-NELCKKD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIE------------LEIE 524
            ..|.|. |.:|... |..|......:||.::|   |.|.:|::.:.:|:            |.:|
Zfish   455 SRCWFEDNAICTGGVDIIYVIIAFVIVLIIVL---GSIGLSLFIRRRIQQIQLIKGPNRILLTLE 516

  Fly   525 GLLWKIDPNEIKGYSGNEIVSSPSKVSLMSAQSYG--SRWTNQFVTSTGR------LRGAVVRIK 581
            .|.: |:|...|.....|.:|. || |.:..:|.|  ||..|...|:|..      ..|..|.:|
Zfish   517 DLTF-INPQLSKRKITLEDLSD-SK-SYIEEKSTGDRSRSVNSMATATHETSNVAVYEGDWVWLK 578

  Fly   582 ELKFPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKL 646
            :......:::.:...|....:::||::|:|.|:|...:.....:||::|::|||:|::.|:|:||
Zfish   579 KFTEGHFKEVKQSTTKIFTKMKDLRNENVNPFLGFFTDCEMFAIVTEHCSRGSLHDLLRNDDVKL 643

  Fly   647 DDLFIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHEL--RQCAENESIG 709
            |.:|.:||:.||||||.|:|:.:.. ||.|||.||||..|::|::||:|.:|:  .|.|..|::.
Zfish   644 DWMFKSSLVLDLIKGMKYLHHREFP-HGRLKSRNCVVDGRFVLKITDYGYNEILETQKAPKETLP 707

  Fly   710 EHQHYRNQLWRAPELLR---NHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKL 771
            ....:    |.|||.||   :...|:.|||||:||||:.|:..|..|:..:...|:||:..|||.
Zfish   708 PEDLF----WTAPEHLRDPESPRKGTYKGDVYSFAIILQEVVVRGAPYCMLGLSPEEIIRKVKKP 768

  Fly   772 PLKGEDPF-RPEVESIIEAESCPDYV-LACI---RDCWAEDPEERPEFSVIRNRLKKMRGGKTKN 831
            |     |. ||.|        .||.. |.||   :.||:|.|:.||.|..|.::.|.:..||..|
Zfish   769 P-----PMCRPTV--------APDQAPLECIQLMKQCWSEQPDRRPPFDQIFDQFKLINKGKKTN 820

  Fly   832 IMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVT 896
            |:|.|:.|:|:|::||||::.|||..|..||.:||.||..|||.||||.|..|..|||..:|.||
Zfish   821 IIDSMLRMLEQYSSNLEDLIRERTEELEVEKQRTEKLLSEMLPPSVAEALKTGASVEPEYFDQVT 885

  Fly   897 IYFSDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRH 961
            ||||||||||.:|:.|.|::||:.|||||::||.::..:||||||||||||||.||||.|||::|
Zfish   886 IYFSDIVGFTTISSLSDPIEVVDLLNDLYSLFDAVLGSHDVYKVETIGDAYMVASGLPKKNGNKH 950

  Fly   962 AGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRME 1026
            |.|||:|:|.:|.:|...::.|.|...:::|||:|:||.||||||||||||||||||||||||||
Zfish   951 AAEIANMSLNILSSVGSFKMRHMPEVPVRIRIGIHSGPCVAGVVGLTMPRYCLFGDTVNTASRME 1015

  Fly  1027 SNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG-ANENAIQKKLVDMMDM 1090
            |.|...:||::......|..|..||..:.||...:||||...|:||.| ||
Zfish  1016 STGLPYRIHVNISTVQILRSLNDGYKIDVRGKTELKGKGIEETYWLVGKAN-------------- 1066

  Fly  1091 PPPLFSRPRKSP 1102
                |::|..:|
Zfish  1067 ----FTKPLPNP 1074

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	88/425 (21%)
		ANF_receptor	48..412	CDD:279440	83/386 (22%)
		PK_GC-A_B	543..827	CDD:270944	106/301 (35%)
		HNOBA	<835..881	CDD:285003	25/45 (56%)
		CYCc	860..1052	CDD:214485	114/191 (60%)
		Guanylate_cyc	887..1074	CDD:278633	109/186 (59%)
gucy2f	NP_571939.2	PBP1_sensory_GC_DEF_like	59..440	CDD:107366	88/422 (21%)
		PK_GC-2D	551..816	CDD:270945	100/282 (35%)
		HNOBA	<825..870	CDD:311573	25/44 (57%)
		CYCc	850..1042	CDD:214485	115/191 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.820