DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG42637 and ADCY1

DIOPT Version :10

Sequence 1:NP_524165.2 Gene:CG42637 / 40153 FlyBaseID:FBgn0261360 Length:1525 Species:Drosophila melanogaster
Sequence 2:NP_066939.1 Gene:ADCY1 / 107 HGNCID:232 Length:1119 Species:Homo sapiens


Alignment Length:293 Identity:82/293 - (27%)
Similarity:140/293 - (47%) Gaps:42/293 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   861 EKMKTED--LLHRMLPQSVAEKLTM----GQGVEPVSYDLVTIYFSDIVGFT----AMSAESTPL 915
            ||:|.::  :|..:||..||:...|    ...:...||..|.:.|:.|..|.    .:...:..:
Human   827 EKVKLDNRRILFNLLPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGV 891

  Fly   916 QVVNFLNDLYTVFDRIIRG---YDVYKVETIGDAYMVVSGLPIKNGDR-------HAGEIASMAL 970
            :.:..||::...||.::..   .|:.|::|||..||...||...:|.:       |...:|..|:
Human   892 ECLRLLNEIIADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAI 956

  Fly   971 ELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIH 1035
            |:...:.:  |.::......||:|::.|||||||:|...|:|.::|:|||.||||:|.|...:|.
Human   957 EMFDVLDE--INYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQ 1019

  Fly  1036 ISNKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG---ANENAIQKKLVDMMDMP------ 1091
            ::.:....|.:....::.  ||.|::||||:::|::|.|   .|.:.|:...:|....|      
Human  1020 VTEEVHRLLRRCPYHFVC--RGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRAGL 1082

  Fly  1092 ----PPLFSRPRKS-----PKLNPDSRQPSIQA 1115
                ||:...|..|     |..:|....||..|
Human  1083 QGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAA 1115

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG42637NP_524165.2 PBP1_SAP_GC-like 26..445 CDD:380593
PK_GC-A_B 543..827 CDD:270944
HNOBA <833..881 CDD:462234 8/21 (38%)
CYCc 860..1052 CDD:214485 59/210 (28%)
ADCY1NP_066939.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..28
AcyC 100..456 CDD:441717
Guanylate_cyc 294..476 CDD:425528
Interaction with calmodulin. /evidence=ECO:0000250 493..520
Guanylate_cyc 859..1056 CDD:425528 59/200 (30%)
Interaction with calmodulin. /evidence=ECO:0000250 1024..1047 6/24 (25%)
Blue background indicates that the domain is not in the aligned region.

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