DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG42637 and Adcy3

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_612178.2	Gene:	Adcy3 / 104111	MGIID:	99675	Length:	1145	Species:	Mus musculus

Alignment Length:	725	Identity:	159/725 - (21%)
Similarity:	276/725 - (38%)	Gaps:	226/725 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   531 DPNEIKGYSGNEIVSSPS-------KVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRK 588
            ||.....||....||.||       :...:|.::.||..             .:.|...|.|..:
Mouse     9 DPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCL-------------CLPRFMRLTFVPE 60

  Fly   589 RDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYD--------IIENEDIK 645
               |.|.:.:....|: ||:            |.::||    ...:|:|        ::.:.| |
Mouse    61 ---SLENLYQTYFKRQ-RHE------------TLLVLV----VFAALFDCYVVVMCAVVFSSD-K 104

  Fly   646 LDDLFIA--SLIHDLI------KGMIYIHNSQLVYHGNLKSSNCVVTSRWML---QVTDF-GLHE 698
            |..|.:|  .|:.|:|      ||::....|:.|          |....|:|   |:..: ||:.
Mouse   105 LAPLMVAGFGLVLDIILFVLCKKGLLPDRVSRKV----------VPYLLWLLISAQIFSYLGLNF 159

  Fly   699 LRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKE 763
            .|..|.::::|         |:|             ..|::|.|.:           .::..|..
Mouse   160 SRAHAASDTVG---------WQA-------------FFVFSFFITL-----------PLSLSPIV 191

  Fly   764 IVDYV----------------KKLPLKGEDPFRPEVESIIEAESCPDYVLACIRDCWAEDPEERP 812
            |:..|                ::..|:|....| |:.:.:....|.  ::..|...:..|.:.|.
Mouse   192 IISVVSCVVHTLVLGVTVAQQQQDELEGMQLLR-EILANVFLYLCA--IIVGIMSYYMADRKHRK 253

  Fly   813 EFSVIRNRLK-KMRGGKTKNIMDQMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQS 876
            .|...|..|: ||                     |||           |:..:.|:|:..:||:.
Mouse   254 AFLEARQSLEVKM---------------------NLE-----------EQSQQQENLMLSILPKH 286

  Fly   877 VAEKLTMGQGVEPVSYDL-------------VTIYFSDIVGFTAMSAESTPLQVVNFLNDLYTVF 928
            ||:::......:....|.             |:|.|:||||||.:|:..:..::|..||:|:..|
Mouse   287 VADEMLKDMKKDESQKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARF 351

  Fly   929 DRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVKQHRIAHRPNETLKLRI 993
            |::...|...:::.:||.|..:.|||....| ||.....|.|.::.|:..  :..:....:.:|:
Mouse   352 DKLAAKYHQLRIKILGDCYYCICGLPDYRED-HAVCSILMGLAMVEAISY--VREKTKTGVDMRV 413

  Fly   994 GMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISN------KCKLALDKLGGG-- 1050
            |:|||.|:.||:|....:|.::...|..|::||:.|...::|||.      |.:..::...||
Mouse   414 GVHTGTVLGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGDGGSR 478

  Fly  1051 --YITEKRGL---VNMKGKGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQ 1110
              |:.|| |:   :.:..|.:|......|.|.:|:..        ..|..|:| .||.| .::::
Mouse   479 CDYLDEK-GIETYLIIASKPEVKKTAQNGLNGSAVPN--------GAPASSKP-SSPAL-IETKE 532

  Fly  1111 PSIQAMHFCGTGS----------------------RRQSTVPRAMD-GESTYSLQGSV------R 1146
            |:..| |..|:.|                      |.|....|.:| .|..:.|...:      |
Mouse   533 PNGSA-HASGSTSEEAEEQEAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLER 596

  Fly  1147 ESPRMVSKRD 1156
            ||.::|.||:
Mouse   597 ESAQVVKKRN 606

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365
		ANF_receptor	48..412	CDD:279440
		PK_GC-A_B	543..827	CDD:270944	62/327 (19%)
		HNOBA	<835..881	CDD:285003	10/45 (22%)
		CYCc	860..1052	CDD:214485	58/214 (27%)
		Guanylate_cyc	887..1074	CDD:278633	57/212 (27%)
Adcy3	NP_612178.2	AC_N	<44..303	CDD:318454	67/370 (18%)
		Guanylate_cyc	310..494	CDD:306677	54/187 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	504..564		14/70 (20%)
		Guanylate_cyc	915..1122	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810