Protein Alignment CG42637 and gucy2c

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_002934756.1
• Gene: gucy2c / 100486678
• XenbaseID: XB-GENE-952210
• Length: 1064
• Species: Xenopus tropicalis
• Alignment Length: 1221
• Identity: 340/1221 - (27%)
• Similarity: 518/1221 - (42%)
• Gaps: 279/1221 - (22%)

  Fly     1 MTRWPFN-----LLLLLSVAVRDCSNHRTVLTVGYLTALTGDLK--TRQGLAISGALTMALDEVN 58
            :|.|..:     :.:.:.|..:|....      |....||.|.:  :....|.||.::.|.:.|.
 Frog    40 LTEWNMDSVQEAVYIGMHVVTKDLEQE------GINVTLTADFQIFSTDLYANSGCISSACEGVE 98

  Fly    59 KDPNLLPNVYLDLRWNDTKGDTVLATKAITEMICDGIATIFGPEGPC----YVEAIVSQSRNIPM 119
            |..||          .||           .::.|    .|.||  .|    |....:..:..:|:
 Frog    99 KLKNL----------RDT-----------GKLGC----VILGP--TCSYATYQMLSLKNTFGVPL 136

  Fly   120 IS-----YKCAEYRASAIPTFARTEPPDTQVVKSLLALLRYY---AWNKFSILYEDVWSPVADLL 176
            ||     ..|..:|     ..||...|..:        :.|:   .|....::....|..|....
 Frog   137 ISAGSFGLSCDYHR-----YLARILLPARK--------MTYFFKEFWQFEGVIKPKKWQSVYIYK 188

  Fly   177 KDQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMS 241
            ||..|:                           |.:||   .|.:: |.:..|    ||.::|..
 Frog   189 KDGNTE---------------------------SCFWY---INALD-TGVSYF----NSALNFKE 218

  Fly   242 SMETAGLFARGEYMVIFVD-----MMVYSEREAE------KYLRRVDQI-----TFMSNCHSTEN 290
            .:.|     ..|.:.:..|     :::...|.::      |.....|.:     .|.:..:..::
 Frog   219 ILRT-----EAELLKVLQDKRKSNVIIMCGRPSDIWNLHNKVAIPQDMVFILIDIFNTGYYDNKS 278

  Fly   291 FNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYLYDSVK 355
            .:...:::|||...|             .:.||......|.::.|:.        ||....|.|.
 Frog   279 SHHYMQNVLVVTIRP-------------SHMSKLSNTTGIAKILVDD--------YAVGYLDGVL 322

  Fly   356 LYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVL 420
            |:...:.|.|:      :.|:     ......||. .:|.:.:...|..| :|:.||.:.|.: |
 Frog   323 LFGHTLKKFLK------SPDI-----KEPFSFIDQ-FRNISIIGAMGPLI-LDEVGDRDLNLT-L 373

  Fly   421 AYKPHKWNN---------SNNMPCNYHMVPVAYFHQGEEHPEYKLINGSIDWPSGGEKPADEPMC 476
            .|.....||         ..|.......||                  ::.| .....|:|.|..
 Frog   374 IYSSTATNNYTELIQFDTRTNKTTVMDAVP------------------NLIW-KNHRLPSDVPQS 419

  Fly   477 GFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWK-IDPNEIKGYSG 540
            |           .:..|:|...|.|::....:..:.::|::::|.|:....|. |.|.:|...:.
 Frog   420 G-----------PHILTIAVFTLTVVVILVLITGLLVFRRYRLENELRQKKWSHISPEKILPLNM 473

  Fly   541 NEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELK----FPRKRDISREIMKEMRL 601
            .|......|:.....:..|.|      ....:....||.:|:||    |..|:.:      |:..
 Frog   474 TETSHVSLKIDDDKRRDSGPR------LQIRKYDKKVVILKDLKHDGNFTEKQKM------ELNK 526

  Fly   602 LRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIK------LDDLFIASLIHDLIK 660
            |.::.:.|:..|.|.......|..|.:||.||||.|:: |::|.      :|..|..|:::|:.|
 Frog   527 LLQIDYYNLTKFYGTVKLDNIIYAVIEYCDKGSLRDVL-NDNISYPDGTFMDWEFKISVMYDIAK 590

  Fly   661 GMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPELL 725
            ||.|:|.|:...||.|||:||||..|.::::|||.         .:||...|   ..||.:||.|
 Frog   591 GMSYLHASKSEVHGRLKSTNCVVDGRMVVKITDFA---------GKSILSPQ---KDLWSSPEHL 643

  Fly   726 RNHIHG-SQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGEDPFRPEV---- 783
            |.  .| |||||||::.:|..||..||..|  .|.: :.||.:..|:.  .||..||||::
 Frog   644 RQ--EGFSQKGDVYSYGVIAQEIMLRKETFYTEQCD-DTKEKISRVQN--YKGACPFRPDLNLDT 703

  Fly   784 --ESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKM----RGGKTKNIMDQMMEMMEK 842
              |..||.     |||  ::.||.||||.||:|..|.|.|.|:    ....|::.||.::..::.
 Frog   704 ANEREIEV-----YVL--VKSCWEEDPERRPDFKKIENTLSKIFSNFHSQTTESYMDTLIRRLQL 761

  Fly   843 YANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTA 907
            |:.|||.:|.|||:|...|:.:.:.|.:.:||..|...|.....|||..::.||||||||||||.
 Frog   762 YSKNLEHLVEERTQLYKAERDRADRLNYLLLPGPVVMSLKETGRVEPEFFEEVTIYFSDIVGFTT 826

  Fly   908 MSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALEL 972
            :...|.|::||:.|||:|..||.|:..:|||||||||||||||||||.:||:.||.:|:.|||::
 Frog   827 ICKYSAPMEVVDMLNDMYKNFDHILDHHDVYKVETIGDAYMVVSGLPNRNGNNHAVDISRMALDI 891

  Fly   973 LHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHIS 1037
            |..:....:.|.|...:.:|||:|:|...|||||:.|||||||||||||||||||.|..|:||::
 Frog   892 LCFMGSFELRHLPGLPVWIRIGIHSGSCAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVN 956

  Fly  1038 NKCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG--------------ANENAIQKKLVDMM 1088
            ......|.:....:..|.||...:||||...|:||||              .|:..:|....:|:
 Frog   957 KSTISILKRTDCEFRYEVRGETYLKGKGTETTYWLTGETEQKYNIPTPPSVENQQRLQSDFAEMI 1021

  Fly  1089 DMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTY 1139
                 :.|..||... ...:::|:..|.:..||....|..   ..|..|||
 Frog  1022 -----MESLKRKEAD-GYKNKEPTRVASYRNGTLEYLQLA---TSDQSSTY 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	83/457 (18%)
		PK_GC-A_B	543..827	CDD:270944	101/306 (33%)
		HNOBA	<833..881	CDD:462234	16/47 (34%)
		CYCc	860..1052	CDD:214485	96/191 (50%)
gucy2c	XP_002934756.1	Periplasmic_Binding_Protein_type1	29..407	CDD:471960	87/505 (17%)
		Protein Kinases, catalytic domain	472..741	CDD:473864	102/305 (33%)
		CYCc	779..971	CDD:214485	96/191 (50%)