Protein Alignment CG42637 and gucy2g

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_009305067.2
• Gene: gucy2g / 100333350
• ZFINID: ZDB-GENE-130531-70
• Length: 1127
• Species: Danio rerio
• Alignment Length: 1162
• Identity: 390/1162 - (33%)
• Similarity: 596/1162 - (51%)
• Gaps: 145/1162 - (12%)

  Fly    44 LAISGALTMALDEVNKDPNLLPNVYLDLRWNDTKGDTVLATKAITEMICD-GIATIFGPEGPCYV 107
            |.:..|:.:|:|::|.:|.|..|...|..:.||..:...:.:...|.:.: .::.:|||  ||..
Zfish    53 LRLGSAMQIAMDKINSNPALSGNFTFDFVYMDTDCNAKTSLRGFIEQVMEQNVSALFGP--PCPE 115

  Fly   108 EA----IVSQSRNIPMISYKCAEYRASAI---PTFARTEPPDTQVVKSLLALLRYYAWNKFSIL- 164
            ||    :::.:.||||..:.....:...|   .|:.:..||..:|.:.||..|.::.|....::
Zfish   116 EAEVTGLIASTWNIPMFGFVGQTPKMDNIQVYDTYIKIVPPLKRVGEILLKALEFFGWKHVGMIG 180

  Fly   165 ---YEDVWSPVADLLK--DQATKRNMTINHKQSFIDNRVKCCEQMLDCCRSGYWYQLVQNTMNRT 224
               ..:.|..|..|.|  ||..:..:|:.....|..:.::..::.|         |::...   .
Zfish   181 GGADANTWDSVEALWKSVDQQLRSKVTVTMGIKFDTSDLEQAKRNL---------QIISKV---A 233

  Fly   225 RIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQI--TFMSNCHS 287
            |:.|.|..|......|...:..||.: |||:.:.|.....|        .:||.:  |.:|..:.
Zfish   234 RVVVVLANAEDSTAMMIEAQKLGLMS-GEYVFLLVQQFEVS--------GKVDNLWKTSVSETNR 289

  Fly   288 T--ENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFS--KFISIYAA 348
            |  :.|:.:   .::...:....||..|..|........||         .||.|  |.:|.|||
Zfish   290 TMLKAFDMV---FVLAEKSYDGYDYYDFFDQAYDKLKGDPF---------YSNLSSVKEVSSYAA 342

  Fly   349 YLYDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSK--IKIDQYG 411
            ||:|:|.|||..:.:..:....:          .:|..::.. :::||.:...|:.  :..|:||
Zfish   343 YLHDAVLLYAMGLKEAFKSGKDI----------RHGREIVQK-LRDRTSIRFYGASGLVHFDEYG 396

  Fly   412 DSEGNFSVLAYKPHKWNNSNNMPCNYHMVPVAYF--HQGEEHPEYKLINGSIDWPSGGEKPADEP 474
            :...::||     :....:..:   ...|.|..|  |.....|..:..|  |.| ..|:.|.|.|
Zfish   397 ERNLDYSV-----YDLQQTETL---IQFVSVLDFDSHTKMIKPTLRFSN--IVW-QNGKPPTDNP 450

  Fly   475 MCGFANELCKKDDTHYTSTVAAVVLGVL-LFCSGVITMSIYRKWKIELEI-EGLLWKIDPNEI-- 535
            .|||.||||:..|...:..|..|.|.:: :....:||:...:|.:::..: |...|.|:.::|
Zfish   451 SCGFDNELCEWLDNEISLLVLLVALPLIGVAAVSLITLLTLQKLRLQSRLDESNWWLINYSDITI 515

  Fly   536 -KGYSGNEIVS---SPSKV------SLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRD 590
             :...|.:|:|   :|||.      |::|:.|..:|  .....:.|..:|..|.||.||.....|
Zfish   516 LREPKGTQILSVNTTPSKCGSGGSQSMLSSNSCNTR--EAIYATVGLFQGNEVGIKYLKNQIIPD 578

  Fly   591 ISR-EIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASL 654
            |.: .|:.|..:|:|::|:|:..|.|..::|..:.:|..||.||||.|::.|.:|.||.:|..|.
Zfish   579 IKKPSIIAEFNMLKEMKHENLVQFFGVCIDPPNVCIVMQYCKKGSLKDVLGNHEIDLDWMFKLSF 643

  Fly   655 IHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIG-EHQHYRNQL 718
            .:|::.||.|||.|.|..||||:.|.|:|.||..::::.|||.|.:...::..|. :...|....
Zfish   644 AYDIVNGMEYIHKSSLKSHGNLRPSTCLVDSRLQIKLSGFGLWEFKCGTKHRLIPLDSPKYEEMY 708

  Fly   719 WRAPELLRN---HIHGSQKGDVYAFAIIMYE-IFSRK-GPFGQINFEPKEIVDYVKKLPLKGEDP 778
            |.|||.||.   ..:|:||||||:||||:.| |:|.: ||:..::.|||||:..: :.|: .|:|
Zfish   709 WTAPEFLREIFYPFNGTQKGDVYSFAIIIRELIYSTEVGPYHDVHLEPKEIIKQL-RTPM-SEEP 771

  Fly   779 FRPEVESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKY 843
            .||    .:.|:.|.:.::..|:.||:|:|:.||.|..||.:|:........||:|.|:..:|||
Zfish   772 LRP----TLSADICDERLIPLIKACWSENPDHRPPFGSIRRQLRDACPESHANILDNMVNKLEKY 832

  Fly   844 ANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAM 908
            ||:||::|.|||..|..||.:.:.||..|||:.:|::|..|:.|||.||::|||:||||||||.|
Zfish   833 ANHLEEVVEERTSQLTVEKSRADKLLSSMLPRYIADQLMAGKSVEPRSYEMVTIFFSDIVGFTTM 897

  Fly   909 SAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELL 973
            .:.|:.|:||..|||||::||.||:.|||||||||||||||.|||||.||..||.||::|||..|
Zfish   898 CSVSSALEVVTLLNDLYSLFDDIIKLYDVYKVETIGDAYMVASGLPISNGTLHAEEISTMALHFL 962

  Fly   974 HAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISN 1038
            .::|:.:|.|.|||.|.||||:::|||||||||.|||||||||||||||||||||...||||||.
Zfish   963 SSIKRFKIRHLPNERLALRIGINSGPVVAGVVGSTMPRYCLFGDTVNTASRMESNSLPLKIHISQ 1027

  Fly  1039 KCKLALDKLGGGYITEKRGLVNMKGKGDVVTWWLTGANENAIQKKLVDMMDMP----PPLFSRPR 1099
            .....|..: |.:..|:||.:.:||||...|:||               :..|    ||......
Zfish  1028 STADILLTI-GTFELEERGDIEIKGKGTQKTFWL---------------LSKPGFTFPPTGQDSN 1076

  Fly  1100 KSPKLNPDSRQPSIQAMHFCGTGSRRQSTVPRAMDGESTYSLQGSVRESPRMVSKRD 1156
            .|||...||       .|.      :|.....|.||:  :..:.:::.:..|....|
Zfish  1077 PSPKSGTDS-------CHI------KQEKTKAANDGD--FKERRTIQRTSAMTKMTD 1118

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	92/422 (22%)
		PK_GC-A_B	543..827	CDD:270944	109/299 (36%)
		HNOBA	<833..881	CDD:462234	22/47 (47%)
		CYCc	860..1052	CDD:214485	119/191 (62%)
gucy2g	XP_009305067.2	Periplasmic_Binding_Protein_type1	37..430	CDD:471960	94/430 (22%)
		Protein Kinases, catalytic domain	535..811	CDD:473864	103/283 (36%)
		HNOBA	<816..870	CDD:462234	24/53 (45%)
		CYCc	850..1041	CDD:214485	119/191 (62%)