Protein Alignment CG42637 and npr2

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: XP_009300100.2
• Gene: npr2 / 100331745
• ZFINID: ZDB-GENE-141030-2
• Length: 1048
• Species: Danio rerio
• Alignment Length: 1137
• Identity: 407/1137 - (35%)
• Similarity: 591/1137 - (51%)
• Gaps: 179/1137 - (15%)

  Fly     8 LLLLLSVAVRDCSNHRTVLTVGYLTALTGDLK-TRQGLAISGALTMALDEVNKDPNLLPNVYLDL 71
            ::||..:.|.:|...:..:||..:  |..:|| :.....:..|:.||.:::.|. .||....::|
Zfish    13 IVLLTRMVVLECRAEKGNITVAVM--LPENLKYSWASPRVLPAIRMAQEKIQKS-GLLRGHTINL 74

  Fly    72 RWNDTKGDTVLATKAITEMICDGIATIFGPE---GPCYVEAIVSQSR-----NIPMISY------ 122
            ....|:..:...::...::|.........|:   ||....::.|..|     .:|:|:.
Zfish    75 LNFSTEDSSGSCSENEAQIIAVDTKLYHKPDAFIGPGCTYSVASVGRFASHWKLPLITAGGPAYG 139

  Fly   123 --KCAEYRASAIPTFARTEPPDTQVVKSLLALLRY----YAWNK--------------------- 160
              |..|::     |..||.|    ..|.|...:.|    :.|:.
Zfish   140 FDKWEEFK-----TIVRTGP----TTKKLGDFVNYLHGQFNWSSRALMIFHDLKQDDRPHYFLSE 195

  Fly   161 --FSILYEDVWSPVADLLKDQATKRNMTINHKQ--SFI-DNRVKCCEQMLDCCRSGYWYQLVQNT 220
              :::|.|:..:.:|...:|:     .|.|:|.  :|| ||
Zfish   196 GIYTVLREENITVLAFPYEDE-----QTYNYKDMITFIKDN------------------------ 231

  Fly   221 MNRTRIYVFLGAANSLVDFMSSMETAGLFARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNC 285
               .||....|...:....|...|.. :.:..:|.:.::|:.      ||.....|......|:.
Zfish   232 ---GRIVYICGPLPTFFQIMKLFEDE-VKSPEDYAIFYLDVF------AESLSGDVPMPWQGSDI 286

  Fly   286 HSTENFNQMARSLLVVASTPPTKDYIQFTKQVQKYSSKPPFNLEIPRLFVESNFSKFISIYAAYL 350
            ...:.........:|....|.:.:|..|.|::.|.:.: .||:::     |.:...||   |...
Zfish   287 QWNDPIKLFQSVFVVTYQEPDSPEYTAFRKELHKRAIQ-DFNVQL-----EPSMMDFI---AGCF 342

  Fly   351 YDSVKLYAWAVDKMLREETRVLTDDVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEG 415
            :|...|||.|:.:.|.:           .|:.|....|...::||....:|| .:.|||......
Zfish   343 HDGFVLYAKALSEALAD-----------GVSQNDGINITARMQNRRLWGVTG-LVSIDQKNARFT 395

  Fly   416 NFSVLAYKPHKWNNSNNMPCNYHMVPVAYFHQGEEHPEYKLINGS----IDWPSGGEKPADEPMC 476
            :||:       |..:|.....|.:|       |..:...|.|..|    |.||.|. .|.|.|.|
Zfish   396 DFSL-------WAMTNLKSGQYAIV-------GHYNGTSKEILWSPTEKIQWPKGC-PPLDYPPC 445

  Fly   477 GFANELCKKDDTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKI--------DPN 533
            ||:.  ||:|...... :.||..|:.|...|:.:..||||.|:|.|:.|:||:|        .||
Zfish   446 GFSP--CKEDHLPVLG-IVAVGSGLALIIFGISSFLIYRKLKLEKELAGMLWRIRWEELQFESPN 507

  Fly   534 EIKGYSGNEIVSSPSKVSLMSAQSYGSRWT----NQFVTSTGRLRGAVVRIKELKFPRKR-DISR 593
            :....:|:.:..|      ....||||..|    .|....||..:|.:|.||.:.  :|| :::|
Zfish   508 KYHKRAGSRLTLS------QRGSSYGSLITAHGKYQLFAKTGYFKGNLVAIKHVN--KKRIELTR 564

  Fly   594 EIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFIASLIHDL 658
            :::.|::.:|:::.:::..||||.::|..|.:||:||.:|||.||:|||.|.||.:|..|||:|:
Zfish   565 QVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENESINLDWMFRYSLINDI 629

  Fly   659 IKGMIYIHNSQLVYHGNLKSSNCVVTSRWMLQVTDFGLHELRQCAENESIGEHQHYRNQLWRAPE 723
            :|||.|:|||.:..|||||||||||.||::|::||:||...|...|||.  .|..|..:||.|||
Zfish   630 VKGMNYLHNSYIGSHGNLKSSNCVVDSRFVLKITDYGLASFRSSCENED--SHALYAKKLWTAPE 692

  Fly   724 LL---RNHIHGSQKGDVYAFAIIMYEIFSRKGPF--GQINFEPKEIVDYVKKLPLKGEDP-FRPE 782
            ||   |:...|:||||||:|.||:.||..|.|||  ..::..||||:..|:    .|:.| |||.
Zfish   693 LLIYDRHPPQGTQKGDVYSFGIILQEIALRNGPFYVEGMDLSPKEIIQKVR----NGQKPYFRPT 753

  Fly   783 VESIIEAESCPDYVLACIRDCWAEDPEERPEFSVIRNRLKKMRGGKTKNIMDQMMEMMEKYANNL 847
            .::   :..|.:..: .:..||:|||.|||:||.|:..:.|.....:.:|::.::..||:|||||
Zfish   754 TDN---SRHCEELTI-LMEGCWSEDPAERPDFSHIKVFIAKFNKEGSTSILNNLLSRMEQYANNL 814

  Fly   848 EDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYFSDIVGFTAMSAES 912
            |::|.|||:...|||.|.|:||:::||.||||:|..|:.|:..::|.||||||||||||:|||||
Zfish   815 ENLVEERTQAYLEEKRKAENLLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTSMSAES 879

  Fly   913 TPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGEIASMALELLHAVK 977
            ||||||..||||||.||.||..:|||||||||||||||||||::||..||.|||.|:|.||..||
Zfish   880 TPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIAGMSLALLEQVK 944

  Fly   978 QHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKL 1042
            ..:|.||||:.|:||||:|||||.||||||.|||||||||||||||||||.||||:||:|:..|.
Zfish   945 TFKIRHRPNDQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESTGEALRIHMSSATKE 1009

  Fly  1043 ALDKLGGGYITEKRGLVNMKGKGDVVTWWLTG 1074
            .||:. |.:..:.||.|.|||||.:.|:||.|
Zfish  1010 VLDEF-GYFELQLRGDVEMKGKGKMRTYWLLG 1040

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593	87/465 (19%)
		PK_GC-A_B	543..827	CDD:270944	122/294 (41%)
		HNOBA	<833..881	CDD:462234	25/47 (53%)
		CYCc	860..1052	CDD:214485	133/191 (70%)
npr2	XP_009300100.2	None