DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG42637 and adcy8

DIOPT Version :9

Sequence 1:	NP_001007096.1	Gene:	CG42637 / 40153	FlyBaseID:	FBgn0261360	Length:	1525	Species:	Drosophila melanogaster
Sequence 2:	NP_001137224.1	Gene:	adcy8 / 100148976	ZFINID:	ZDB-GENE-070912-197	Length:	1225	Species:	Danio rerio

Alignment Length:	1246	Identity:	251/1246 - (20%)
Similarity:	438/1246 - (35%)	Gaps:	386/1246 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 LDCCRS--------GYWYQLV--------QNTMNRTRIY--VFLGAANSLVDFMSSMETA----- 246
            :||..|        ||.|:.|        ..:.:..|:|  .|||.....|..|:.::..
Zfish   106 IDCAPSNSDFFLSWGYTYRGVIFPTLRYAFKSRDLERLYQRYFLGQRRKSVVVMNILDVVTKLTL 170

  Fly   247 ----------------GL---FARGEYMVIFVDMMVYSEREAEKYLRRVDQITFMSNCHSTENFN 292
                            |:   |..|..:||...::|..:..:..||:....:|:::
Zfish   171 LVLHLTLASTPMDPIKGMLLGFFTGIEVVICALVVVRKDTSSHGYLQYSGAVTWVA--------- 226

  Fly   293 QMARSLLVV----ASTPPTKDYIQFTKQVQKYSSKP-PFNLEI------------------PRLF 334
             ||..:|..    ........|:.|| ....||..| |....|                  ||..
Zfish   227 -MATQILATGLGYGLLGDGIGYVLFT-LFATYSMLPLPLTWAIVAGLLTSALHIALQLLVPPRAQ 289

  Fly   335 VESN-----FSKFISI-----YAAYLYDSVKLYAW-----AVDKMLREETR----------VLTD 374
            :.:|     ...|:.|     :.:||.|..:..|:     .::..||.||.          ||..
Zfish   290 ISTNQLLAQVLLFLCINTAGMFISYLSDRAQRQAFLETRRCIEARLRLETENQRQERLVLSVLPR 354

  Fly   375 DVIFEVASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYHM 439
            .|:.|:.::.|.|.|..::::.:      :|.|.:|    .|.|:|......:.|.:.......:
Zfish   355 FVVLEMINDMTNVEDETLQHQFH------RIYIHRY----ENVSILFADVKGFTNLSTTLSAQEL 409

  Fly   440 VPV-----AYFHQ-GEEHP--EYKLINGSIDWPSGGEKP-ADEPMC------------GFANELC 483
            |.:     |.|.: ..||.  ..|::.......||..:| .|...|            .:.....
Zfish   410 VRMLNELFARFDRLAHEHHCLRIKILGDCYYCVSGLPEPRPDHAHCCVEMGLSMIKTIRYVRSRT 474

  Fly   484 KKD-DTHYTSTVAAVVLGVLLFCSGVITMSIYRKWKIELEIEGLLWKIDPNEIKGYSGNEIVSS- 546
            |.| |........:|:.|||    |:      |||:.::    ..|.:|       ..|::.|.
Zfish   475 KHDIDMRIGIHSGSVLCGVL----GL------RKWQFDV----WSWDVD-------IANKLESGG 518

  Fly   547 -PSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIKELKFPRKRDISREIMKE-----MRLLREL 605
             |.::.:..|.........:.....|:.|.        .|.|:.:|...::|:     :.|..::
Zfish   519 IPGRIHISKAALDCLNGDYEVEEGHGKDRN--------DFLRRHNIETFLIKQPEESLLTLPEDI 575

  Fly   606 RHDNIN---------SFIGASVEP-----------------TR--ILLVTDYCAKGSLYDIIENE 642
            ..|:.|         ||...:..|                 ||  |.|:.::.|: :|:....::
Zfish   576 MRDSTNQSDHRTSNTSFTEGTWSPELPFHNIVGKQNTLAALTRHSINLLPNHLAQ-ALHVRAGSQ 639

  Fly   643 DI--------------KLDDLFIASLIHDLIKGMIYIHNSQL---VYHGNLKSSNCVV------- 683
            :|              ||....|:.......:.::....||:   |:..||..:..|:
Zfish   640 EINARMQSTIALRSGDKLRQEHISPFSLTFREALLEHKYSQMRDEVFKSNLVCAFIVLFFITGIQ 704

  Fly   684 ----TSRWMLQVTDFGLHELRQC-------AENESIGEHQHYRNQLWRAPELLR------NHIHG 731
                ::|.:..:..|.:..|..|       ||:...            .|.:||      |..:.
Zfish   705 SLLPSARMVTMLIQFSVLILLHCCLVVVTTAEDYKC------------LPLVLRKACCWVNETYA 757

  Fly   732 SQKGDVY---------AFAIIMYEIFSRKGPFGQINFEPKEIVDYVKKLPLKGEDPFRPE---VE 784
            ::...::         |...|::..|.:.|.|....|.....:..:         .|.||   ..
Zfish   758 ARNVVIFLSILINFLAAMINILWCDFDKSGSFRNQTFNASASIPDI---------CFYPEYFVFT 813

  Fly   785 SIIEAESCPDY----------VLACIRDCWAEDPEE--RPEF----SVIRNRLKKMRGGKTKNIM 833
            .::...:|..:          :|..:...:|...|.  .|.|    ::..|:.|...|.|..:::
Zfish   814 GVLAMVTCAVFLRLNSVLKLAILLIMIAIYAVLTEAFYTPLFIRYDTLTLNQSKSFLGTKETSLL 878

  Fly   834 DQMMEMMEKYANNLEDIVTERTRLLCEEKMK------------TEDLLHRMLPQSVA----EKLT 882
            ...|.::..:.:..:...|.|...|...:.|            .|::|..:||..||    ||..
Zfish   879 LMAMFLLAVFYHGQQLEYTARLDFLWRVQAKEEINEMRELREHNENMLRNILPSHVARHFLEKDR 943

  Fly   883 MGQGVEPVSYDLVTIYFSDIVGF------TAMSAESTPLQVVNFLNDLYTVFDRII---RGYDVY 938
            ..:.:...|||.|.:.|:.|.||      |.|:.:.  ::.:..||::...||.::   |..|:.
Zfish   944 DNEELYSQSYDTVGVMFASIPGFADFYSQTEMNNQG--VECLRLLNEIIADFDELLGEERFQDIE 1006

  Fly   939 KVETIGDAYMVVSGL-PIKN--GDR--HAGEIASMALELLHAVKQHRIAHRPNETLKLRIGMHTG 998
            |::|||..||.|||| |.|.  .|:  |...:|..|:.|..::::  |........:|||||..|
Zfish  1007 KIKTIGSTYMAVSGLSPEKQQCEDKWGHLCALADFAIALNESIQE--INKHSFNNFQLRIGMAHG 1069

  Fly   999 PVVAGVVGLTMPRYCLFGDTVNTASRMESNGEALKIHISNKCKLALDKLGGGYITEKRGLVNMKG 1063
            .|||||:|...|:|.::|.|||.||||:|.|.:.||.:..:....|::  .|:..|.||.:.:||
Zfish  1070 SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGKIQLPEETYAILNE--RGFAFEYRGEIYVKG 1132

  Fly  1064 ----KGDVVTWWLTGANENAIQKKLVDMMDMPPPLFSRPRKSPKLNPDSRQPSIQAMHFCGTGSR 1124
                :|.:.|.::.|..:             |.||..:|||
Zfish  1133 ISEQEGKIRTHFMIGRVQ-------------PNPLILQPRK------------------------ 1160

  Fly  1125 RQSTVPRAMDGESTYSLQGSVRESPRMVSKRDRDRERPPIN-----GLGAGHFVGGALLESAQAS 1184
                    :.|:  |||...|.   .:|...:|.:::..:|     |:..||:....||....:.
Zfish  1161 --------LTGQ--YSLAAVVL---GLVQSLNRQKQKQILNENNNSGIMKGHYNRRTLLAPGGSD 1212

  Fly  1185 LSTLNHSETNE 1195
            .|   |:|..:
Zfish  1213 TS---HAEVTD 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_001007096.1	PBP1_Speract_GC_like	26..445	CDD:107365	63/334 (19%)
		ANF_receptor	48..412	CDD:279440	57/296 (19%)
		PK_GC-A_B	543..827	CDD:270944	58/387 (15%)
		HNOBA	<835..881	CDD:285003	12/61 (20%)
		CYCc	860..1052	CDD:214485	71/221 (32%)
		Guanylate_cyc	887..1074	CDD:278633	69/204 (34%)
adcy8	NP_001137224.1	AC_N	<135..374	CDD:292831	47/249 (19%)
		CYCc	340..538	CDD:214485	42/228 (18%)
		Guanylate_cyc	379..563	CDD:278633	40/216 (19%)
		DUF1053	592..685	CDD:283888	14/93 (15%)
		CYCc	919..1123	CDD:214485	70/209 (33%)
		Guanylate_cyc	948..1147	CDD:278633	69/204 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910