Protein Alignment CG42637 and gucy1a2

DIOPT Version :10

• Sequence 1: NP_524165.2
• Gene: CG42637 / 40153
• FlyBaseID: FBgn0261360
• Length: 1525
• Species: Drosophila melanogaster
• Sequence 2: NP_001120379.1
• Gene: gucy1a2 / 100145454
• XenbaseID: XB-GENE-1011801
• Length: 712
• Species: Xenopus tropicalis
• Alignment Length: 528
• Identity: 146/528 - (27%)
• Similarity: 234/528 - (44%)
• Gaps: 143/528 - (27%)

  Fly   600 RLLREL---RHDNINSF----------IGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDLFI 651
            |:||.:   .||..|.|          ||..|.......:....|.|:|.         |....:
 Frog   165 RVLRAVGGTLHDFFNGFDALLEHIRTSIGRQVTLESPSFLCKELADGTLL---------LSCFHL 220

  Fly   652 ASLIHDLIKGMI---------------YIHN------SQLVYHGNLKSSNCVVTSRWMLQVTDFG 695
            ..::...:||:|               .::|      ..::..||.   ||:.
 Frog   221 HHIVGFAMKGLIKAAGKKIYQLKVEVEQVNNVNEKPCPDIIRPGNF---NCLT------------ 270

  Fly   696 LHELRQCAENESIGEHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFE 760
             .::::| :|.:          |.:||.|..:||....:        |....|.|..|| .:.|:
 Frog   271 -FKIKEC-DNAN----------LMKAPLLQSSHIPSDLR--------ISISTFCRAFPF-HLMFD 314

  Fly   761 PKEIV----DYVKKL-------PLKGEDPFR---PEV----ESIIEAESCPDYVLACIRDCWAED 807
            |..::    :.::||       .::..|.|.   |::    |.::...|.| :|:....|....:
 Frog   315 PNMLILQLGEGLRKLIKCEVHKTMQFHDSFEIVSPKISCTFEQVLLRLSTP-FVIRNKPDAPTFE 378

  Fly   808 PEER-----------PEFSVIR-------NRLKKMRG--------------------GKTKNIMD 834
            .:::           ||.|.|.       ::|.::.|                    |:.....|
 Frog   379 NKDKVMEVKGQMIYVPESSSILFLGSPRVDKLDELMGRGLHLSDIPIHDATRDVILVGEQAKAQD 443

  Fly   835 QMMEMMEKYANNLEDIVTERTRLLCEEKMKTEDLLHRMLPQSVAEKLTMGQGVEPVSYDLVTIYF 899
            .:.:.|:|....||    :..:.|.|||.||.|||:.:.|..||::|..|:.|:...:|.||:.|
 Frog   444 GLKKRMDKLKATLE----KTHQALEEEKKKTVDLLYSIFPGDVAQQLWEGKSVQARKFDDVTMLF 504

  Fly   900 SDIVGFTAMSAESTPLQVVNFLNDLYTVFDRIIRGYDVYKVETIGDAYMVVSGLPIKNGDRHAGE 964
            ||||||||:.|:.||:||::.||:|||.||......|:||||||||||.|.:|| ::..:.||..
 Frog   505 SDIVGFTAVCAQCTPMQVISMLNELYTRFDYQCGFLDIYKVETIGDAYCVAAGL-LRQSNSHAKP 568

  Fly   965 IASMALELLHAVKQHRIAHRPNETLKLRIGMHTGPVVAGVVGLTMPRYCLFGDTVNTASRMESNG 1029
            ||.|||:::...::  :.......:|:|||:|:|.|:|||||:.||||||||:.|..||:.||..
 Frog   569 IALMALKMMELSEE--VLTPDGRPIKMRIGIHSGSVLAGVVGVRMPRYCLFGNNVTLASKFESGS 631

  Fly  1030 EALKIHIS 1037
            ...:|::|
 Frog   632 HPRRINVS 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG42637	NP_524165.2	PBP1_SAP_GC-like	26..445	CDD:380593
		PK_GC-A_B	543..827	CDD:270944	53/316 (17%)
		HNOBA	<833..881	CDD:462234	17/47 (36%)
		CYCc	860..1052	CDD:214485	86/178 (48%)
gucy1a2	NP_001120379.1	Pap_E4	30..>86	CDD:367150
		HNOB	<137..248	CDD:462233	17/91 (19%)
		HNOBA	296..486	CDD:462234	41/203 (20%)
		Guanylate_cyc	492..679	CDD:425528	73/151 (48%)