DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Trpml and mcoln1a

DIOPT Version :9

Sequence 1:	NP_649145.1	Gene:	Trpml / 40152	FlyBaseID:	FBgn0262516	Length:	652	Species:	Drosophila melanogaster
Sequence 2:	NP_001315094.1	Gene:	mcoln1a / 406689	ZFINID:	ZDB-GENE-040426-2704	Length:	581	Species:	Danio rerio

Alignment Length:	564	Identity:	213/564 - (37%)
Similarity:	327/564 - (57%)	Gaps:	36/564 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 PEFPGSSAASYQEERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNH 144
            |...|...|..:||.:||||::|||:|.||:|||.:.|:|.::||:||.:||.||.||..|....
Zfish    42 PVTDGWIGADPEEEELRRKLKYFFMSPCEKYQAKGRKPFKLILQILKIVIVTAQLVLFGLSNEMA 106

  Fly   145 INYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSEFFDTVQYAVNGYANVS-RSIGPY 208
            :.:..:|..:|.||||:.:..|.:.         .|:|.:|:.:|.:.|||..|.::: .::|.|
Zfish   107 VMFKEENTASFKHLFLKDYADSDDA---------LAVYTQSDVYDHMFYAVEQYLSLADTTVGQY 162

  Fly   209 DY---PTPNNTMPPLKLCLQNYREGTIFGFNESYIFDPHIDEVCERLPPNVTTIGVENYLRQRDV 270
            .|   ...|.:  .|.||.|.|::|.|...|:::|.||.:...|..:.|..|..........|:.
Zfish   163 AYVYGVGVNGS--ALSLCQQYYKKGRIDPANDTFIIDPLVVTDCIGVNPLSTPTAAGTGRDYRNF 225

  Fly   271 EVNFASLVSAQLTFKIKTVNFKA---NGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRL 332
            .:.|..|::..:.|::|.:|.:.   |    ..|||:.|.|:|..:|:.|.|::.:|||.:|:..
Zfish   226 TLKFHKLINVTIQFQLKAINLQTIIHN----EIPDCYTFLITILLDNKAHSGKVRISLDNKASIK 286

  Fly   333 KCHGATDFISDANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSF 397
            :|.   |.....:.||..|.:.::.|.|.|..|..||.|::.|..:|:...|.:|::...:.:.:
Zfish   287 ECR---DPSVSGHPDSNARVLFDLAVALVCVFSLLLCGRSIIRGIILQNEFVKYFKTSLKRHVCW 348

  Fly   398 DGRLEFVNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGF 462
            ..|:||:|.|||::|.:|:|.|.||.:|..||.:.|  ..:|.|.:.||...||||.||:|||.|
Zfish   349 GDRMEFINGWYILLIISDLLTITGSIIKIGIELKNL--SSYDECGILLGTSTLLVWVGVIRYLTF 411

  Fly   463 FKTYNVVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDD 527
            |:.||::|:||:.|.|.::||.....:||.|:.||||::|||||:|||||::.|||||:||||||
Zfish   412 FQKYNILIVTLQAAFPNVIRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSSVSECLFSLINGDD 476

  Fly   528 MFATFATLSSKATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTDLKAF 592
            ||.||:.:...:..:|.|.|:|||:||||:||:|||||||:|..||:|||...::....|||.||
Zfish   477 MFVTFSGMQESSMLVWVFSQVYLYTFISLFIYMVLSLFIALITGAYETIKHQTQEPIHITDLHAF 541

  Fly   593 VGTRTAEDISSGVFMTDLDDFDQTSFLDVVKSICCCGRCGRHQE 636
            :...| :...||.|..  .:....||      .|||.|...:::
Zfish   542 IAECT-DTPCSGKFRG--IETSPCSF------FCCCDRTTTYED 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Trpml	NP_649145.1	Ion_trans	403..578	CDD:278921	95/174 (55%)
mcoln1a	NP_001315094.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592024
Domainoid	1	1.000	197	1.000	Domainoid score	I3054
eggNOG	1	0.900	-	-		E1_KOG3733
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	383	1.000	Inparanoid score	I2003
OMA	1	1.010	-	-		QHG49191
OrthoDB	1	1.010	-	-		D1379516at2759
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		otm25448
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3353
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.700