DRSC/TRiP Functional Genomics Resources

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Protein Alignment Trpml and Mcoln3

DIOPT Version :9

Sequence 1:NP_649145.1 Gene:Trpml / 40152 FlyBaseID:FBgn0262516 Length:652 Species:Drosophila melanogaster
Sequence 2:NP_001012059.1 Gene:Mcoln3 / 308022 RGDID:1308420 Length:553 Species:Rattus norvegicus


Alignment Length:566 Identity:230/566 - (40%)
Similarity:349/566 - (61%) Gaps:42/566 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 REEQP-EFPGSSAASYQ---EERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKIFLVTMQLCL 136
            ::|.| .|..||:.|.|   |::|||||:||||||.||:.|:.:.|:|..:||:||.:||:||.|
  Rat    15 QDESPCTFYPSSSQSEQLLLEDQMRRKLKFFFMNPCEKFWARGRKPWKLAIQILKIAMVTIQLVL 79

  Fly   137 FAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSEFFDTVQYAVNGYANV 201
            |..|....:.:..:|..||.||||:|: ..|..::|       |:|.:::.:|.:.:||..|..:
  Rat    80 FGLSNQMVVAFKEENTIAFKHLFLKGY-MDRMDDTY-------AVYTQNDVYDQIIFAVTRYLQL 136

  Fly   202 SR-SIGPYDYPTPNNTMPPLKLCLQNYREGTIFGFNESYIFDPHIDEVCERLPP----NVTTIGV 261
            .. |:|.:.|.........:.:|...||:|||...|:::..||.::..|..:.|    ::.|.| 
  Rat   137 RNISVGNHAYENKGTKQSAMAVCQHFYRQGTICPGNDTFDIDPEVETDCFLIEPEEAFHMGTPG- 200

  Fly   262 ENYLRQRDVEVNFASLVSAQLTFKIKTVNFKANGGPLSAPDCFRFDISITFNNRDHDGQMLLSLD 326
            ||.|   ::.::|..|::.:|.||:|.:|.:..... ..|||:.|.::|||:|:.|.|::.:|||
  Rat   201 ENKL---NLTLDFHRLLTVELQFKLKAINLQTVRHQ-ELPDCYDFTLTITFDNKAHSGRIKISLD 261

  Fly   327 AEATRLKC---HGATDFISDANFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFR 388
            .:.:..:|   |.:.....:.::    ..:.:.||:|||..|..||.|::.|...|:...||||.
  Rat   262 NDISIRECKDWHVSGSIQKNTHY----MMIFDAFVILTCLSSLVLCARSVIRGLQLQQEFVNFFL 322

  Fly   389 SQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVW 453
            ..:.||:|...::||:|.||||||.:|:|.|:||.||.:|:.:.|.  .:|.||:.||...:|||
  Rat   323 LHYKKEVSASDQMEFINGWYIMIIVSDILTIVGSILKMEIQAKSLT--SYDVCSILLGTSTMLVW 385

  Fly   454 FGVLRYLGFFKTYNVVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLATTSEC 518
            .||:||||||..||::||||:.|.|.::||...|.:||.|:.||||::|||||.|||||...|||
  Rat   386 LGVIRYLGFFAKYNLLILTLQAALPNVIRFCCCAAMIYLGYCFCGWIVLGPYHEKFRSLNKVSEC 450

  Fly   519 LFALINGDDMFATFATLSSKATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTIKAYYKDG 583
            ||:||||||||:|||.:..|:..:|.|.::||||||||:||::||||||:|.|.|:|||.|.:||
  Rat   451 LFSLINGDDMFSTFAKMQQKSYLVWLFSRVYLYSFISLFIYMILSLFIALITDTYETIKHYQQDG 515

  Fly   584 FPTTDLKAFVGTRTAEDI-SSGVFMTDLDDFDQTSFLDVVKSICCC 628
            ||.|:|:.|:.  ..:|: :||.:..: ||...:.|       |||
  Rat   516 FPETELRKFIA--ECKDLPNSGKYRLE-DDPPGSLF-------CCC 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TrpmlNP_649145.1 Ion_trans 403..578 CDD:278921 101/174 (58%)
Mcoln3NP_001012059.1 ELD_TRPML3 109..277 CDD:410968 49/179 (27%)
PKD_channel <343..508 CDD:400395 95/166 (57%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166350332
Domainoid 1 1.000 212 1.000 Domainoid score I2686
eggNOG 1 0.900 - - E1_KOG3733
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H10118
Inparanoid 1 1.050 407 1.000 Inparanoid score I1828
OMA 1 1.010 - - QHG49191
OrthoDB 1 1.010 - - D1379516at2759
OrthoFinder 1 1.000 - - FOG0001492
OrthoInspector 1 1.000 - - otm45544
orthoMCL 1 0.900 - - OOG6_102454
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X949
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1514.670

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