Protein Alignment Trpml and Mcoln1

DIOPT Version :10

• Sequence 1: NP_649145.1
• Gene: Trpml / 40152
• FlyBaseID: FBgn0262516
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: XP_006248816.1
• Gene: Mcoln1 / 288371
• RGDID: 1308953
• Length: 620
• Species: Rattus norvegicus
• Alignment Length: 639
• Identity: 230/639 - (35%)
• Similarity: 346/639 - (54%)
• Gaps: 111/639 - (17%)

  Fly    65 GSGT------APPSVDGREEQPEFP--------GSSAASY---QEERMRRKLQFFFMNPIEKWQA 112
            |||.      ||.|.....||...|        |:|.|..   :||.:||:|::|||:|.:|::|
  Rat     9 GSGERGRREGAPGSATSETEQLLTPNPGYGTQAGTSPAPTTPPEEEDLRRRLKYFFMSPCDKFRA 73

  Fly   113 KRKFPYKFVVQIVKIFLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGW-DSSREVESYPPAV 176
            |.:.|.|.::|:|||.:||:||.||..|....:.:..:|..||.||||.|: |.|.:.
  Rat    74 KGRKPCKLMLQVVKILVVTVQLILFGLSNQLVVTFREENTIAFRHLFLLGYSDGSDDT------- 131

  Fly   177 GPFALYLKSEFFDTVQYAVNGYANVSR-SIGPYDY------PTPNNTMPPLKLCLQNYREGTIFG 234
              ||.|.:.:.:..:.|||:.|..:.. |:|.|.|      |..|.:  .|.||.:.|..|.:..
  Rat   132 --FAAYTREQLYQAIFYAVDQYLTLPEISLGRYAYVRGGGGPWANGS--ALALCQRYYHRGHVDP 192

  Fly   235 FNESYIFDPHIDEVCERL-----PPNVTT------IGVENYLRQRDVEVNFASLVSAQLTFKIKT 288
            .|:::..||.:...|.::     ||::.:      .|..:|   :::.:.|..|::..:.|::||
  Rat   193 ANDTFDIDPRVVTDCIQVDPPDRPPDIPSEDLDFLDGSTSY---KNITLKFHKLINVTIHFQLKT 254

  Fly   289 VNFKA--NGGPLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLKC-------HGATDFISDA 344
            :|.::  |.   ..|||:.|.|.|||:|:.|.|::.:.|:.:....:|       ||
  Rat   255 INLQSLINN---EIPDCYTFSILITFDNKAHSGRIPIRLETQTHIQECKHPSVSRHG-------- 308

  Fly   345 NFDSMLRSVLNIFVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYI 409
              |:..|.:.::.|:|||:|||.||.|:|.|.:||:...|.|...:.|:|:|...||||||.|||
  Rat   309 --DNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVVFMWRRRGREISLWERLEFVNGWYI 371

  Fly   410 MIIFNDVLLIIGSALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYN------- 467
            :::.:|||.|.|:.:|..||.:.|.  .:|.||:.||...||||.||:|||.||..||
  Rat   372 LLVTSDVLTISGTIMKIGIEAKNLA--SYDVCSILLGTSTLLVWVGVIRYLTFFHKYNTHESLYQ 434

  Fly   468 ------------------VVILTLKKAAPKILRFLIAALLIYAGFVFCGWLILGPYHMKFRSLAT 514
                              ::|.||:.|.|.::||.....:||.|:.||||::|||||:|||||:.
  Rat   435 GRTTGACPYLPIQLSPAVILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSM 499

  Fly   515 TSECLFALINGDDMFATFATLSS---KATWLWWFCQIYLYSFISLYIYVVLSLFIAVIMDAYDTI 576
            .|||||:||||||||.|||.:.:   :::.:|.|.|:||||||||:||:|||||||:|..|||||
  Rat   500 VSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTI 564

  Fly   577 KAYYKDGFPTTDLKAFVGTRTAEDISSGVFMTDLDDFDQTSFLDVVKSICCCGR 630
            |.....|...::|:|:: .:..:..:||.|        :.........:|||||
  Rat   565 KHPGGTGTEKSELQAYI-EQCQDSPTSGKF--------RRGSGSTCSLLCCCGR 609

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpml	NP_649145.1	ELD_TRPML	174..335	CDD:410965	46/187 (25%)
		Ion_trans	<403..578	CDD:459842	99/202 (49%)
Mcoln1	XP_006248816.1	ELD_TRPML1	127..307	CDD:410966	47/196 (24%)
		PLN03223	<457..565	CDD:215637	64/107 (60%)