Protein Alignment Trpml and cup-5

DIOPT Version :9

• Sequence 1: NP_649145.1
• Gene: Trpml / 40152
• FlyBaseID: FBgn0262516
• Length: 652
• Species: Drosophila melanogaster
• Sequence 2: NP_001254945.1
• Gene: cup-5 / 176074
• WormBaseID: WBGene00000846
• Length: 668
• Species: Caenorhabditis elegans
• Alignment Length: 566
• Identity: 211/566 - (37%)
• Similarity: 336/566 - (59%)
• Gaps: 42/566 - (7%)

  Fly    63 SAGSGTAPPSVDGREEQPEFPGSSAASYQEERMRRKLQFFFMNPIEKWQAKRKFPYKFVVQIVKI 127
            ::.:.:..|:::.:|...:.|.....:  .||:||.||||||||:|||:.:.:.|||.|:|::||
 Worm    19 ASSNASRRPTINFQEIMEDLPHHERET--GERLRRHLQFFFMNPMEKWKVRHQLPYKLVLQVLKI 81

  Fly   128 FLVTMQLCLFAHSRYNHINYTGDNRFAFSHLFLRGWDSSREVESYPPAVGPFALYLKSEFFDTVQ 192
            ..|||||.|||..|.:|:::..|......|.||:.|:..|:...||||.|.:::|......:.:.
 Worm    82 VFVTMQLILFAEMRMSHVDFLEDTTTVMRHRFLKEWNDDRDALQYPPAEGRYSVYDDQGLSEHLS 146

  Fly   193 YAVNGYANV-SRSIGPYDY-----PTPN-------NTMPPLKLCLQNYREGTIFGFNESYIFDPH 244
            :.:|.|.:: :.|...:.|     |:.|       .::||:::.:......|:  .|.:|.||
 Worm   147 FLINSYYSIRNDSFASFSYDVVSHPSGNLGAQISFESIPPIEVLIDRISNVTV--NNNTYNFD-- 207

  Fly   245 IDEVCERLPPNVT-----TIG-----VENYLRQRDVEV---NFASLVSAQLTFKIKTVNFKANGG 296
            |.||.:....|:|     .||     |.:.|..|.:..   :...:.:.|..|:::|:::....|
 Worm   208 IREVKDTKRLNLTETEVFQIGQSDDAVRDILATRGITFLPEDALKISTVQFKFRLRTIHYSPTAG 272

  Fly   297 PLSAPDCFRFDISITFNNRDHDGQMLLSLDAEATRLK-CHG--ATDFISDA--NFDSMLRSVLNI 356
            . ..|:|::..:||.|:|..|.||:.::|....:.:. |:|  ....:|..  :||::|....:|
 Worm   273 D-QKPECYKISVSIKFDNSRHTGQVHVTLSTVVSYVNVCNGRIIKGQVSGVGWSFDTLLIGGTDI 336

  Fly   357 FVLLTCALSFALCTRALWRAYLLRCTTVNFFRSQFGKELSFDGRLEFVNFWYIMIIFNDVLLIIG 421
            |||:.|.||..||.|||.:|:||:..|.::|.:....:::...:|:|:|.||:||:.||.|:|||
 Worm   337 FVLILCILSLILCCRALIKAHLLQIKTSDYFENVLKNKITVTDQLDFLNLWYVMIVVNDALIIIG 401

  Fly   422 SALKEQIEGRYLVVDQWDTCSLFLGIGNLLVWFGVLRYLGFFKTYNVVILTLKKAAPKILRFLIA 486
            :..|..||.:......:...|:|||:|.|||:.|||||.|||..||:::||||::||.|:||:..
 Worm   402 TVAKISIEFQDFDNSLFTLTSIFLGMGALLVYVGVLRYFGFFSQYNILMLTLKRSAPNIMRFMTC 466

  Fly   487 ALLIYAGFVFCGWLILGPYHMKFRSLATTSECLFALINGDDMFATFATLSSKATWLWWFCQIYLY 551
            |:::||||:..||:|:|||.||||:||.:||.||:|:|||||||||.|::...|.:..|..:|:|
 Worm   467 AIVLYAGFLIAGWVIIGPYSMKFRTLAESSEALFSLLNGDDMFATFYTINDSNTVIKVFGTVYIY 531

  Fly   552 SFISLYIYVVLSLFIAVIMDAYDTIKAYYKDGFPTTD----LKAFV 593
            .|:||:||||||||||:|||||:.:|..|.||....:    |:.||
 Worm   532 LFVSLFIYVVLSLFIAIIMDAYEVVKDRYSDGLRAIEKRGCLRDFV 577

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Trpml	NP_649145.1	Ion_trans	403..578	CDD:278921	96/174 (55%)
cup-5	NP_001254945.1	PKD_channel	<382..556	CDD:369653	96/173 (55%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160164192
Domainoid	1	1.000	172	1.000	Domainoid score	I2245
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10118
Inparanoid	1	1.050	376	1.000	Inparanoid score	I1208
Isobase	1	0.950	-	0	Normalized mean entropy	S4518
OMA	1	1.010	-	-		QHG49191
OrthoDB	1	1.010	-	-		D1379516at2759
OrthoFinder	1	1.000	-	-		FOG0001492
OrthoInspector	1	1.000	-	-		oto18962
orthoMCL	1	0.900	-	-		OOG6_102454
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3353
SonicParanoid	1	1.000	-	-		X949
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.790