DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment verm and Cda4

DIOPT Version :9

Sequence 1:	NP_001163469.1	Gene:	verm / 40149	FlyBaseID:	FBgn0261341	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_728468.1	Gene:	Cda4 / 33144	FlyBaseID:	FBgn0052499	Length:	486	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	172/494 - (34%)
Similarity:	262/494 - (53%)	Gaps:	83/494 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 CREVYRCDSAGEDGTWRLAPIRCAGGLAFDVLRQLCDWKSNVKSCDVLEKPRKAKPILKTDEPIC 138
            ||..|:|    .||...|.  ||..||.||.:::.|.:|...| |.    |....|...|:.|
  Fly    43 CRRFYQC----VDGYPYLN--RCPSGLFFDDVQKFCTFKDEAK-CG----PLPTTPAPATEAP-- 94

  Fly   139 PEGKLSCGDGECLDKELFCNGKSDCKDESDENACSVDEDPNRAPECDPTQCALPDCFCSADGTRI 203
                                                   .:.|..|:...||||.||||.|||:|
  Fly    95 ---------------------------------------ADTAQRCNTENCALPYCFCSKDGTQI 120

  Fly   204 PGGIEPQQVPQMITITFNGAVNVDNIDLYEDIFNGQRQNPNGCSIKGTFFVSHKYTNYSAVQDLH 268
            ||.:||:::||:|.:||:||||::|...|:.||:|:|:|||||.|:||||:||:|:||..:|.|.
  Fly   121 PGDLEPEKIPQIIMLTFDGAVNLNNYQHYQKIFDGKRKNPNGCLIRGTFFMSHEYSNYQQIQHLG 185

  Fly   269 RRGHEISVFSLTHKDDPNYWTGGSYDDWLAEMAGSRLIVERFANITDGSIIGMRAPYLRVGGNKQ 333
            ..||||...|::.:..   .....|::|:.||.|.|.|:..|||::...::|||||:|:.|.|.|
  Fly   186 YYGHEIGTESISQQQG---LQDKGYEEWVGEMIGMREILRHFANVSVNDVVGMRAPFLKPGRNTQ 247

  Fly   334 FEMMADQFFVYDASITASLGRVPIWPYTLYFRMPHKCNGNAHNCPSRSHP-VWEMVMNELDRRDD 397
            ::::.|..::||:|||.....||:|||||.:::.|:|...  .||||:.| |||:.:|
  Fly   248 YKVLEDFGYIYDSSITVPPVPVPVWPYTLDYKISHECKSG--TCPSRTFPGVWEVPLN------- 303

  Fly   398 PTFDESLPG--CHMVDSC--SNVASGDQFARLLRHNFNRHYNSNRAPLGLHFHASWLKSKKEYRD 458
            ..:.|...|  |..:|.|  .|:...:.| :.|:.:|:|:|..|:||..:.||.:|.:: |...:
  Fly   304 THYVEGYEGGHCPYLDQCVLHNLDEEEVF-QWLQEDFSRYYEQNKAPYMMPFHTNWFQT-KPLEN 366

  Fly   459 ELIKFIEEMLGRNDVFFVTNLQVIQWMQNPTELNSLRDFQEWKEKCD----VKGQPYCSLPNACP 519
            .|.||::..|...||:.:|..|::|::.:|.||..:...:.|  |||    |..:| |::...|.
  Fly   367 GLHKFLDWALELPDVYILTVTQMLQYVTDPKELRDVSQIESW--KCDKSVSVAPKP-CNIWQTCA 428

  Fly   520 LTTRELPGETLR----LFTCMECPNNYPWILDPTGDGFS 554
            |..: :|.:.|.    :.||.||||.|||:.|..|.|.:
  Fly   429 LPFK-IPEQNLTDTRYMETCRECPNVYPWLGDAGGTGIA 466

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
verm	NP_001163469.1	CBM_14	57..118	CDD:366726	16/43 (37%)
		LDLa	138..172	CDD:238060	0/33 (0%)
		CE4_CDA_like_1	213..488	CDD:200596	107/279 (38%)
Cda4	NP_728468.1	CBM_14	33..80	CDD:279884	16/43 (37%)
Cda4	NP_728468.1	CE4_CDA_like_1	130..396	CDD:200596	107/279 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	121	1.000	Domainoid score	I3513
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1060206at2759
OrthoFinder	1	1.000	-	-		FOG0003270
OrthoInspector	1	1.000	-	-		otm14253
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR45985
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4295
	7	7.020