DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and STE4

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_014855.3	Gene:	STE4 / 854387	SGDID:	S000005738	Length:	423	Species:	Saccharomyces cerevisiae

Alignment Length:	382	Identity:	109/382 - (28%)
Similarity:	181/382 - (47%)	Gaps:	51/382 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDS 71
            |:::|:.:||....|.:|....:    :|:|...: ...||......:||||.||::...::.||
Yeast    45 ESKQLHAQINKAKHKIQDASLFQ----MANKVTSL-TKNKINLKPNIVLKGHNNKISDFRWSRDS 104

  Fly    72 RHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVN--NRD 134
            :..::.|.||.::|||:.:..|...|||.|.||::.|.|||...||..|::|.||:|.|:  ||.
Yeast   105 KRILSASQDGFMLIWDSASGLKQNAIPLDSQWVLSCAISPSSTLVASAGLNNNCTIYRVSKENRV 169

  Fly   135 ASGVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLS 199
            |..||.:.|   |:..::|...|.|:.|::|.||||....||:.|..:..:::.|.||:..|::.
Yeast   170 AQNVASIFK---GHTCYISDIEFTDNAHILTASGDMTCALWDIPKAKRVREYSDHLGDVLALAIP 231

  Fly   200 PD------MKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARM 258
            .:      ..|:.:...|....:||.|.....|.|:.:|.|::::.:...|....:.|::....|
Yeast   232 EEPNSENSSNTFASCGSDGYTYIWDSRSPSAVQSFYVNDSDINALRFFKDGMSIVAGSDNGAINM 296

  Fly   259 YDLRADQQIAQY-------------------------EPPQ----------KNTGFTSCALSTSG 288
            ||||:|..||.:                         :.||          .|.|..|...|.||
Yeast   297 YDLRSDCSIATFSLFRGYEERTPTPTYMAANMEYNTAQSPQTLKSTSSSYLDNQGVVSLDFSASG 361

  Fly   289 RYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGMCLASTSWDQQVRLW 345
            |.:.....:.....||.:|....|.|.||..|:|.:...|:|:.:.:.|||..:::|
Yeast   362 RLMYSCYTDIGCVVWDVLKGEIVGKLEGHGGRVTGVRSSPDGLAVCTGSWDSTMKIW 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	100/342 (29%)
		WD40	51..345	CDD:238121	98/336 (29%)
		WD40 repeat	64..99	CDD:293791	10/34 (29%)
		WD40 repeat	105..147	CDD:293791	18/43 (42%)
		WD40 repeat	152..187	CDD:293791	12/34 (35%)
		WD40 repeat	194..229	CDD:293791	7/40 (18%)
		WD40 repeat	235..271	CDD:293791	10/60 (17%)
		WD40 repeat	279..315	CDD:293791	9/35 (26%)
		WD40 repeat	321..345	CDD:293791	6/23 (26%)
STE4	NP_014855.3	WD40	87..419	CDD:238121	99/335 (30%)
		WD40 repeat	95..132	CDD:293791	10/36 (28%)
		WD40 repeat	138..179	CDD:293791	18/43 (42%)
		WD40 repeat	184..218	CDD:293791	12/33 (36%)
		WD40 repeat	226..266	CDD:293791	7/39 (18%)
		WD40 repeat	273..329	CDD:293791	10/55 (18%)
		WD40 repeat	352..388	CDD:293791	9/35 (26%)
		WD40 repeat	394..418	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346072
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	238	1.000	Inparanoid score	I698
Isobase	1	0.950	-	0	Normalized mean entropy	S419
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		otm46827
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
TreeFam	0	0.000	Not matched by this tool.
	9	8.840