DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and Gnb5

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_113958.1	Gene:	Gnb5 / 83579	RGDID:	620759	Length:	353	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	125/347 - (36%)
Similarity:	191/347 - (55%)	Gaps:	23/347 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KIDPETQKLYD-EINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVH 66
            |::.|..||:| |::                .:|::...:|   :....:::.||||.|||..:.
  Rat    25 KLEEERAKLHDVELH----------------QVAERVEALG---QFVMKTRRTLKGHGNKVLCMD 70

  Fly    67 FAGDSRHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVN 131
            :..|.|..|:.|.|||:|:||::|.||...:.:...|||..|::|||..:||||:||:|:||.:.
  Rat    71 WCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLT 135

  Fly   132 NRDASGVAKMVKELMGYEGFLSSCRFLD-DGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAG 195
            ......:|...|.:..:..:||:|.|.: |..::|.|||.....||:|.|.....|:||..|:..
  Rat   136 FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLC 200

  Fly   196 LSLSPDM--KTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARM 258
            |.|:|..  .|:::|..||.|.:||:|.....|.|..|:.||:||.|:|||..|||.|:|.|.|:
  Rat   201 LDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDVNSVRYYPSGDAFASGSDDATCRL 265

  Fly   259 YDLRADQQIAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITC 323
            ||||||:::|.|.......|.:|...|.|||.|..|..:..::.||.:|......|.|||||::.
  Rat   266 YDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVST 330

  Fly   324 ISLCPNGMCLASTSWDQQVRLW 345
            :.:.|:|....|.|||..:|:|
  Rat   331 LRVSPDGTAFCSGSWDHTLRVW 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	116/302 (38%)
		WD40	51..345	CDD:238121	116/296 (39%)
		WD40 repeat	64..99	CDD:293791	13/34 (38%)
		WD40 repeat	105..147	CDD:293791	16/41 (39%)
		WD40 repeat	152..187	CDD:293791	13/35 (37%)
		WD40 repeat	194..229	CDD:293791	12/36 (33%)
		WD40 repeat	235..271	CDD:293791	21/35 (60%)
		WD40 repeat	279..315	CDD:293791	10/35 (29%)
		WD40 repeat	321..345	CDD:293791	7/23 (30%)
Gnb5	NP_113958.1	WD40	56..353	CDD:238121	117/297 (39%)
		WD 1	61..100		18/38 (47%)
		WD40 repeat	66..103	CDD:293791	14/36 (39%)
		WD 2	103..142		16/38 (42%)
		WD40 repeat	109..151	CDD:293791	16/41 (39%)
		WD 3	151..192		13/40 (33%)
		WD40 repeat	156..192	CDD:293791	13/35 (37%)
		WD 4	194..236		14/41 (34%)
		WD40 repeat	199..236	CDD:293791	12/36 (33%)
		WD 5	237..276		22/38 (58%)
		WD40 repeat	242..278	CDD:293791	21/35 (60%)
		WD 6	278..320		11/41 (27%)
		WD40 repeat	286..322	CDD:293791	10/35 (29%)
		WD 7	323..352		12/28 (43%)
		WD40 repeat	328..352	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.820