DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and GNB4

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_067642.1	Gene:	GNB4 / 59345	HGNCID:	20731	Length:	340	Species:	Homo sapiens

Alignment Length:	339	Identity:	148/339 - (43%)
Similarity:	229/339 - (67%)	Gaps:	2/339 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDS 71
            |.::|..|...:..:.:|.:|:..|.||.....:|..|.:|:..:::.|:||:.|:.::|:..||
Human     3 ELEQLRQEAEQLRNQIQDARKACNDATLVQITSNMDSVGRIQMRTRRTLRGHLAKIYAMHWGYDS 67

  Fly    72 RHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRDAS 136
            |..|:.|.||||||||::|.||:..|||||:||||.|::||||:|||||:||.|::|::..|:
Human    68 RLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE-- 130

  Fly   137 GVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPD 201
            |..::.:||.|:.|:||.||||||..::|.|||.....||:|...:|..|.||:||:..||||||
Human   131 GNVRVSRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPD 195

  Fly   202 MKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMYDLRADQQ 266
            |:|:::|:.|.::||||:|:...:|.|.||..|:::|.:.|:|:.||:.|:|.|.|::||||||:
Human   196 MRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQE 260

  Fly   267 IAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGM 331
            :..|.......|.||.|.|.|||.|:.|..:.|.:.|||:|....|.|:||:||::|:.:..:||
Human   261 LLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGM 325

  Fly   332 CLASTSWDQQVRLW 345
            .:|:.|||..:|:|
Human   326 AVATGSWDSFLRIW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	137/299 (46%)
		WD40	51..345	CDD:238121	136/293 (46%)
		WD40 repeat	64..99	CDD:293791	18/34 (53%)
		WD40 repeat	105..147	CDD:293791	20/41 (49%)
		WD40 repeat	152..187	CDD:293791	16/34 (47%)
		WD40 repeat	194..229	CDD:293791	16/34 (47%)
		WD40 repeat	235..271	CDD:293791	15/35 (43%)
		WD40 repeat	279..315	CDD:293791	15/35 (43%)
		WD40 repeat	321..345	CDD:293791	8/23 (35%)
GNB4	NP_067642.1	WD40	48..340	CDD:238121	137/294 (47%)
		WD 1	53..92		20/38 (53%)
		WD40 repeat	58..95	CDD:293791	18/36 (50%)
		WD 2	95..134		23/40 (58%)
		WD40 repeat	101..141	CDD:293791	20/41 (49%)
		WD 3	141..179		18/37 (49%)
		WD40 repeat	146..181	CDD:293791	16/34 (47%)
		WD 4	182..221		19/38 (50%)
		WD40 repeat	188..223	CDD:293791	16/34 (47%)
		WD 5	224..263		18/38 (47%)
		WD40 repeat	229..265	CDD:293791	15/35 (43%)
		WD 6	268..307		15/38 (39%)
		WD40 repeat	273..309	CDD:293791	15/35 (43%)
		WD 7	310..339		12/28 (43%)
		WD40 repeat	315..339	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.920