DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and gnb2

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_005165361.1	Gene:	gnb2 / 541370	ZFINID:	ZDB-GENE-050320-65	Length:	344	Species:	Danio rerio

Alignment Length:	343	Identity:	149/343 - (43%)
Similarity:	228/343 - (66%)	Gaps:	6/343 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDS 71
            |.::|..|...:..:.:|.:|:..|.||......:..|.:|:..:::.|:||:.|:.::|:..||
Zfish     3 ELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67

  Fly    72 RHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRDAS 136
            |..|:.|.||||||||::|.||:..|||||:||||.|::||||||||||:||.|::|.:..|:
Zfish    68 RLLVSASQDGKLIIWDSYTTNKIHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTRE-- 130

  Fly   137 GVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPD 201
            |..::.:||.|:.|:||.|||:||..:||.|||.....||:|.|.:|..|:||:||:..|||:||
Zfish   131 GNVRVSRELPGHTGYLSCCRFIDDNQIITSSGDTTCALWDIETGQQTTLFSGHSGDVMSLSLAPD 195

  Fly   202 MKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMYDLRADQQ 266
            .:|:|:|:.|.:.||||:|:...:|.|.||:.|:::.|:.|||..||:.|:|.|.|::||||||:
Zfish   196 SRTFISGACDASIKLWDIRDSMCRQTFTGHESDINAACFFPSGSAFATGSDDATCRLFDLRADQE 260

  Fly   267 IAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMK----QRHTGTLSGHENRITCISLC 327
            :..|.......|.||.|.|.|||.|:.|..:.|.:.||.||    .:|||.|:||:||::|:.:.
Zfish   261 LCLYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGERAGKHTGVLAGHDNRVSCLGVT 325

  Fly   328 PNGMCLASTSWDQQVRLW 345
            .:||.:.:.|||..:::|
Zfish   326 DDGMAVCTGSWDSFLKIW 343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	139/303 (46%)
		WD40	51..345	CDD:238121	138/297 (46%)
		WD40 repeat	64..99	CDD:293791	18/34 (53%)
		WD40 repeat	105..147	CDD:293791	21/41 (51%)
		WD40 repeat	152..187	CDD:293791	17/34 (50%)
		WD40 repeat	194..229	CDD:293791	15/34 (44%)
		WD40 repeat	235..271	CDD:293791	16/35 (46%)
		WD40 repeat	279..315	CDD:293791	17/39 (44%)
		WD40 repeat	321..345	CDD:293791	6/23 (26%)
gnb2	XP_005165361.1	WD40	48..344	CDD:238121	139/298 (47%)
		WD40	<49..344	CDD:225201	139/297 (47%)
		WD40 repeat	58..95	CDD:293791	18/36 (50%)
		WD40 repeat	101..141	CDD:293791	21/41 (51%)
		WD40 repeat	146..181	CDD:293791	17/34 (50%)
		WD40 repeat	188..223	CDD:293791	15/34 (44%)
		WD40 repeat	229..265	CDD:293791	16/35 (46%)
		WD40 repeat	273..313	CDD:293791	17/39 (44%)
		WD40 repeat	319..343	CDD:293791	6/23 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920