DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and gnb3b

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_998367.1	Gene:	gnb3b / 406483	ZFINID:	ZDB-GENE-040426-2280	Length:	338	Species:	Danio rerio

Alignment Length:	339	Identity:	140/339 - (41%)
Similarity:	213/339 - (62%)	Gaps:	4/339 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDS 71
            |.:::..|..|:..:.:..:|:..|..:|.....:...|:::..::|.||||:.|:.::|:..|:
Zfish     3 EMEQMKKEAEGLKTQIEAARKAAHDTDMAAAAAGVAPAPRVQLKTRKTLKGHLAKIYAMHWCTDN 67

  Fly    72 RHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRDAS 136
            |..|:.|.||||:|||..:.|||..:||:|:||||.:::||||.||.||:||.||||::.    :
Zfish    68 RLMVSASQDGKLLIWDAHSGNKVNAVPLKSSWVMTCSYAPSGNLVASGGLDNMCTVYNLK----T 128

  Fly   137 GVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPD 201
            .|.|.||||..:.|:||.|||:.|..::|.|||.....||||.|.:...|..|.||...||||||
Zfish   129 PVIKTVKELDAHTGYLSCCRFISDTEIVTSSGDTTCALWDLETGKQKTVFLNHIGDCMCLSLSPD 193

  Fly   202 MKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMYDLRADQQ 266
            ...:|:|:.|..|||||:|:...||.|.||..|::::.:.||...|.:.|:|.|.:|||:||||:
Zfish   194 NNMFISGACDSLAKLWDIRDGQCKQTFQGHTSDINAISFLPSATAFITGSDDCTCKMYDIRADQE 258

  Fly   267 IAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGM 331
            :..|:....|:|.||.|||.|||.:..|..:.|.:.||::|....|.||||:||::|..:..:||
Zfish   259 VICYQDSALNSGVTSVALSVSGRLIFAGYDDFNCNIWDSLKGEKVGVLSGHDNRVSCTGVPGDGM 323

  Fly   332 CLASTSWDQQVRLW 345
            |:.:.|||..:::|
Zfish   324 CVCTGSWDSFLKIW 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	133/299 (44%)
		WD40	51..345	CDD:238121	132/293 (45%)
		WD40 repeat	64..99	CDD:293791	15/34 (44%)
		WD40 repeat	105..147	CDD:293791	22/41 (54%)
		WD40 repeat	152..187	CDD:293791	15/34 (44%)
		WD40 repeat	194..229	CDD:293791	17/34 (50%)
		WD40 repeat	235..271	CDD:293791	13/35 (37%)
		WD40 repeat	279..315	CDD:293791	14/35 (40%)
		WD40 repeat	321..345	CDD:293791	7/23 (30%)
gnb3b	NP_998367.1	WD40	<46..338	CDD:225201	133/296 (45%)
		WD40	48..338	CDD:238121	133/294 (45%)
		WD40 repeat	58..95	CDD:293791	15/36 (42%)
		WD40 repeat	101..139	CDD:293791	22/41 (54%)
		WD40 repeat	144..179	CDD:293791	15/34 (44%)
		WD40 repeat	186..221	CDD:293791	17/34 (50%)
		WD40 repeat	227..263	CDD:293791	13/35 (37%)
		WD40 repeat	271..307	CDD:293791	14/35 (40%)
		WD40 repeat	313..337	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	8	7.880