DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and GNB1

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_001269468.1	Gene:	GNB1 / 2782	HGNCID:	4396	Length:	340	Species:	Homo sapiens

Alignment Length:	339	Identity:	147/339 - (43%)
Similarity:	228/339 - (67%)	Gaps:	2/339 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDS 71
            |..:|..|...:..:.:|.:|:.||.||:....::..|.:|:..:::.|:||:.|:.::|:..||
Human     3 ELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67

  Fly    72 RHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRDAS 136
            |..|:.|.||||||||::|.|||..|||||:||||.|::||||:|||||:||.|::|::..|:
Human    68 RLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTRE-- 130

  Fly   137 GVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPD 201
            |..::.:||.|:.|:||.||||||..::|.|||.....||:|.|.:|..|.||.||:..|||:||
Human   131 GNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPD 195

  Fly   202 MKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMYDLRADQQ 266
            .:.:::|:.|.:||||||||...:|.|.||:.|::::|:.|:|..||:.|:|.|.|::||||||:
Human   196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQE 260

  Fly   267 IAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGM 331
            :..|.......|.||.:.|.|||.|:.|..:.|.:.||.:|....|.|:||:||::|:.:..:||
Human   261 LMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGM 325

  Fly   332 CLASTSWDQQVRLW 345
            .:|:.|||..:::|
Human   326 AVATGSWDSFLKIW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	136/299 (45%)
		WD40	51..345	CDD:238121	135/293 (46%)
		WD40 repeat	64..99	CDD:293791	19/34 (56%)
		WD40 repeat	105..147	CDD:293791	20/41 (49%)
		WD40 repeat	152..187	CDD:293791	17/34 (50%)
		WD40 repeat	194..229	CDD:293791	16/34 (47%)
		WD40 repeat	235..271	CDD:293791	15/35 (43%)
		WD40 repeat	279..315	CDD:293791	13/35 (37%)
		WD40 repeat	321..345	CDD:293791	7/23 (30%)
GNB1	NP_001269468.1	WD40	48..340	CDD:238121	136/294 (46%)
		WD 1	53..83		15/29 (52%)
		WD40 repeat	58..95	CDD:293791	19/36 (53%)
		WD 2	95..125		20/29 (69%)
		WD40 repeat	101..141	CDD:293791	20/41 (49%)
		WD 3	141..170		14/28 (50%)
		WD40 repeat	146..181	CDD:293791	17/34 (50%)
		WD 4	182..212		14/29 (48%)
		WD40 repeat	188..223	CDD:293791	16/34 (47%)
		WD 5	224..254		12/29 (41%)
		WD40 repeat	229..265	CDD:293791	15/35 (43%)
		WD 6	268..298		10/29 (34%)
		WD40 repeat	273..309	CDD:293791	13/35 (37%)
		WD 7	310..340		12/30 (40%)
		WD40 repeat	315..339	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S419
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.870