DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and git5

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_595613.1	Gene:	git5 / 2539974	PomBaseID:	SPBC32H8.07	Length:	305	Species:	Schizosaccharomyces pombe

Alignment Length:	307	Identity:	113/307 - (36%)
Similarity:	171/307 - (55%)	Gaps:	8/307 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 DMGDVPKIRFSSKKILKGHINKVNSVHFAGDSRHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWV 104
            |.|....:.....::||..:.|:..:..:.|.::.::.|.:..|::||..|:|||......|.|:
pombe     2 DSGSRVNVNIQGTRVLKNKLGKIPDIDISTDGKYLLSASTNDVLLVWDLHTSNKVAFFEAPSVWI 66

  Fly   105 MTVAFSPSGNFVACGGMDNQCTVYDVNNRDASGVAKMVKELMGYEGFLSSCRFLDDGHLITGSGD 169
            ||.|||||...:|.||::|.|.|||.:..||..|     ||:|:.||:|.|:::|||||:|||||
pombe    67 MTCAFSPSTKSIAAGGLNNFCVVYDTSVPDADPV-----ELVGHAGFVSCCKYVDDGHLLTGSGD 126

  Fly   170 MKICHWDLEKGVKTMDFNGHAGDIAGLSLSP-DMKTYITGSVDKTAKLWDVREEGHKQMFFGHDM 233
            .....||:|:........||..||..|...| :...::||..||.|||||:|.......|.|:..
pombe   127 KTCMFWDIEQAKAISVLKGHEMDIVSLDFLPSNPNLFVTGGCDKLAKLWDLRAAYCCATFPGNTS 191

  Fly   234 DVSSVCYHPSGFGFASCSEDQTARMYDLRADQQIAQYEPPQKNTGFTSCALSTSGRYLMCGGIEG 298
            |::|:.:.||...|.:.:||..||.:|:||..:|.||..| .::...|...|.||:.|.... :.
pombe   192 DINSISFFPSNADFVTGAEDGIARCFDIRASAEIFQYSSP-SSSPINSVLFSKSGKLLFIAK-DK 254

  Fly   299 NVHSWDTMKQRHTGTLSGHENRITCISLCPNGMCLASTSWDQQVRLW 345
            ....||::..:...:|:||||||:.::|..:|..||:.|||:.||||
pombe   255 TCEVWDSISSKTITSLTGHENRISSLALTSDGTMLATGSWDECVRLW 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	109/300 (36%)
		WD40	51..345	CDD:238121	109/294 (37%)
		WD40 repeat	64..99	CDD:293791	9/34 (26%)
		WD40 repeat	105..147	CDD:293791	20/41 (49%)
		WD40 repeat	152..187	CDD:293791	15/34 (44%)
		WD40 repeat	194..229	CDD:293791	12/35 (34%)
		WD40 repeat	235..271	CDD:293791	13/35 (37%)
		WD40 repeat	279..315	CDD:293791	7/35 (20%)
		WD40 repeat	321..345	CDD:293791	10/23 (43%)
git5	NP_595613.1	WD40	1..>302	CDD:225201	113/307 (37%)
		WD40	14..302	CDD:238121	111/295 (38%)
		WD40 repeat	26..61	CDD:293791	9/34 (26%)
		WD40 repeat	66..104	CDD:293791	20/42 (48%)
		WD40 repeat	110..145	CDD:293791	15/34 (44%)
		WD40 repeat	150..187	CDD:293791	13/36 (36%)
		WD40 repeat	194..229	CDD:293791	13/34 (38%)
		WD40 repeat	236..271	CDD:293791	7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	257	1.000	Inparanoid score	I758
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	1	1.000	-	-		otm47282
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
TreeFam	1	0.960	-	-
	8	7.920