DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and GNB5

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	NP_057278.2	Gene:	GNB5 / 10681	HGNCID:	4401	Length:	395	Species:	Homo sapiens

Alignment Length:	347	Identity:	124/347 - (35%)
Similarity:	191/347 - (55%)	Gaps:	23/347 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KIDPETQKLYD-EINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVH 66
            |::.|..||:| |::                .:|::...:|   :....:::.||||.|||..:.
Human    67 KLEEERAKLHDVELH----------------QVAERVEALG---QFVMKTRRTLKGHGNKVLCMD 112

  Fly    67 FAGDSRHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVN 131
            :..|.|..|:.|.|||:|:||::|.||...:.:...|||..|::|||..:||||:||:|:||.:.
Human   113 WCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLT 177

  Fly   132 NRDASGVAKMVKELMGYEGFLSSCRFLD-DGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAG 195
            ......:|...|.:..:..:||:|.|.: |..::|.|||.....||:|.|.....|:||..|:..
Human   178 FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLC 242

  Fly   196 LSLSPDM--KTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARM 258
            |.|:|..  .|:::|..||.|.:||:|.....|.|..|:.|::||.|:|||..|||.|:|.|.|:
Human   243 LDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRL 307

  Fly   259 YDLRADQQIAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITC 323
            ||||||:::|.|.......|.:|...|.|||.|..|..:..::.||.:|......|.|||||::.
Human   308 YDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVST 372

  Fly   324 ISLCPNGMCLASTSWDQQVRLW 345
            :.:.|:|....|.|||..:|:|
Human   373 LRVSPDGTAFCSGSWDHTLRVW 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	115/302 (38%)
		WD40	51..345	CDD:238121	115/296 (39%)
		WD40 repeat	64..99	CDD:293791	13/34 (38%)
		WD40 repeat	105..147	CDD:293791	16/41 (39%)
		WD40 repeat	152..187	CDD:293791	13/35 (37%)
		WD40 repeat	194..229	CDD:293791	12/36 (33%)
		WD40 repeat	235..271	CDD:293791	20/35 (57%)
		WD40 repeat	279..315	CDD:293791	10/35 (29%)
		WD40 repeat	321..345	CDD:293791	7/23 (30%)
GNB5	NP_057278.2	WD40	98..395	CDD:238121	116/297 (39%)
		WD 1	103..142		18/38 (47%)
		WD40 repeat	108..145	CDD:293791	14/36 (39%)
		WD 2	145..184		16/38 (42%)
		WD40 repeat	151..193	CDD:293791	16/41 (39%)
		WD 3	193..234		13/40 (33%)
		WD40 repeat	198..234	CDD:293791	13/35 (37%)
		WD 4	236..278		14/41 (34%)
		WD40 repeat	241..278	CDD:293791	12/36 (33%)
		WD 5	279..318		21/38 (55%)
		WD40 repeat	284..320	CDD:293791	20/35 (57%)
		WD 6	320..362		11/41 (27%)
		WD40 repeat	328..364	CDD:293791	10/35 (29%)
		WD 7	365..394		12/28 (43%)
		WD40 repeat	370..394	CDD:293791	7/23 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820