Protein Alignment Gbeta76C and GNB5

DIOPT Version :10

• Sequence 1: NP_523720.2
• Gene: Gbeta76C / 40148
• FlyBaseID: FBgn0004623
• Length: 346
• Species: Drosophila melanogaster
• Sequence 2: NP_057278.2
• Gene: GNB5 / 10681
• HGNCID: 4401
• Length: 395
• Species: Homo sapiens
• Alignment Length: 347
• Identity: 124/347 - (35%)
• Similarity: 191/347 - (55%)
• Gaps: 23/347 - (6%)

  Fly     3 KIDPETQKLYD-EINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVH 66
            |::.|..||:| |::                .:|::...:|   :....:::.||||.|||..:.
Human    67 KLEEERAKLHDVELH----------------QVAERVEALG---QFVMKTRRTLKGHGNKVLCMD 112

  Fly    67 FAGDSRHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVN 131
            :..|.|..|:.|.|||:|:||::|.||...:.:...|||..|::|||..:||||:||:|:||.:.
Human   113 WCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSGCAIACGGLDNKCSVYPLT 177

  Fly   132 NRDASGVAKMVKELMGYEGFLSSCRFLD-DGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAG 195
            ......:|...|.:..:..:||:|.|.: |..::|.|||.....||:|.|.....|:||..|:..
Human   178 FDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCALWDVESGQLLQSFHGHGADVLC 242

  Fly   196 LSLSPDM--KTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARM 258
            |.|:|..  .|:::|..||.|.:||:|.....|.|..|:.|::||.|:|||..|||.|:|.|.|:
Human   243 LDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDATCRL 307

  Fly   259 YDLRADQQIAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITC 323
            ||||||:::|.|.......|.:|...|.|||.|..|..:..::.||.:|......|.|||||::.
Human   308 YDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSILFGHENRVST 372

  Fly   324 ISLCPNGMCLASTSWDQQVRLW 345
            :.:.|:|....|.|||..:|:|
Human   373 LRVSPDGTAFCSGSWDHTLRVW 394

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	51..345	CDD:238121	115/296 (39%)
		WD40 repeat	64..99	CDD:293791	13/34 (38%)
		WD40 repeat	105..147	CDD:293791	16/41 (39%)
		WD40 repeat	152..187	CDD:293791	13/35 (37%)
		WD40 repeat	194..229	CDD:293791	12/36 (33%)
		WD40 repeat	235..271	CDD:293791	20/35 (57%)
		WD40 repeat	279..315	CDD:293791	10/35 (29%)
		WD40 repeat	321..345	CDD:293791	7/23 (30%)
GNB5	NP_057278.2	WD40	98..395	CDD:238121	116/297 (39%)
		WD 1	103..142		18/38 (47%)
		WD40 repeat	108..145	CDD:293791	14/36 (39%)
		WD 2	145..184		16/38 (42%)
		WD40 repeat	151..193	CDD:293791	16/41 (39%)
		WD 3	193..234		13/40 (33%)
		WD40 repeat	198..234	CDD:293791	13/35 (37%)
		WD 4	236..278		14/41 (34%)
		WD40 repeat	241..278	CDD:293791	12/36 (33%)
		WD 5	279..318		21/38 (55%)
		WD40 repeat	284..320	CDD:293791	20/35 (57%)
		WD 6	320..362		11/41 (27%)
		WD40 repeat	328..364	CDD:293791	10/35 (29%)
		WD 7	365..394		12/28 (43%)
		WD40 repeat	370..394	CDD:293791	7/23 (30%)