DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gbeta76C and gnb4a

DIOPT Version :9

Sequence 1:	NP_523720.2	Gene:	Gbeta76C / 40148	FlyBaseID:	FBgn0004623	Length:	346	Species:	Drosophila melanogaster
Sequence 2:	XP_021322372.1	Gene:	gnb4a / 100332205	ZFINID:	ZDB-GENE-091102-1	Length:	340	Species:	Danio rerio

Alignment Length:	339	Identity:	145/339 - (42%)
Similarity:	227/339 - (66%)	Gaps:	2/339 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ETQKLYDEINGMIQKFKDDQKSKADCTLADKCGDMGDVPKIRFSSKKILKGHINKVNSVHFAGDS 71
            |.::|..|...:..:.:|.:|:.:|.:|:.....:..|.:|:..:::.|:||:.|:.::|:..||
Zfish     3 ELEQLRQEAEQLRNQIRDARKACSDSSLSQITAGLDSVGRIQMRTRRTLRGHLAKIYAMHWGTDS 67

  Fly    72 RHCVTGSLDGKLIIWDTWTANKVQIIPLRSAWVMTVAFSPSGNFVACGGMDNQCTVYDVNNRDAS 136
            |..|:.|.|||||:||::|.||:..|||||:||||.|::||||:|||||:||.|::|.:..|:
Zfish    68 RLLVSASQDGKLIVWDSYTTNKIHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYSLKTRE-- 130

  Fly   137 GVAKMVKELMGYEGFLSSCRFLDDGHLITGSGDMKICHWDLEKGVKTMDFNGHAGDIAGLSLSPD 201
            |..::.:||.|:.|:||.||||||..::|.|||.....||:|.|.:|..|.||:||:..||||||
Zfish   131 GNVRVTRELPGHTGYLSCCRFLDDSQIVTSSGDTTCALWDIETGQQTTTFTGHSGDVMSLSLSPD 195

  Fly   202 MKTYITGSVDKTAKLWDVREEGHKQMFFGHDMDVSSVCYHPSGFGFASCSEDQTARMYDLRADQQ 266
            .||:::|:.|.::||||:|:...:|.|.||..|:::||:.|:|..|.:.|:|.|.|::||||||:
Zfish   196 SKTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVCFFPNGNAFTTGSDDATCRLFDLRADQE 260

  Fly   267 IAQYEPPQKNTGFTSCALSTSGRYLMCGGIEGNVHSWDTMKQRHTGTLSGHENRITCISLCPNGM 331
            :..|.......|.||.|.|.|||.|:.|..:.|.:.||.:|....|.|:||:||::|:.:..:||
Zfish   261 LMMYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDMLKGERAGVLAGHDNRVSCLGVTSDGM 325

  Fly   332 CLASTSWDQQVRLW 345
            .:|:.|||..:|:|
Zfish   326 AVATGSWDSFLRIW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gbeta76C	NP_523720.2	WD40	<45..345	CDD:225201	136/299 (45%)
		WD40	51..345	CDD:238121	135/293 (46%)
		WD40 repeat	64..99	CDD:293791	17/34 (50%)
		WD40 repeat	105..147	CDD:293791	20/41 (49%)
		WD40 repeat	152..187	CDD:293791	17/34 (50%)
		WD40 repeat	194..229	CDD:293791	16/34 (47%)
		WD40 repeat	235..271	CDD:293791	15/35 (43%)
		WD40 repeat	279..315	CDD:293791	14/35 (40%)
		WD40 repeat	321..345	CDD:293791	8/23 (35%)
gnb4a	XP_021322372.1	WD40	48..340	CDD:238121	136/294 (46%)
		WD40 repeat	58..95	CDD:293791	17/36 (47%)
		WD40 repeat	101..141	CDD:293791	20/41 (49%)
		WD40 repeat	146..181	CDD:293791	17/34 (50%)
		WD40 repeat	188..223	CDD:293791	16/34 (47%)
		WD40 repeat	229..265	CDD:293791	15/35 (43%)
		WD40 repeat	273..309	CDD:293791	14/35 (40%)
		WD40 repeat	315..339	CDD:293791	8/23 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0286
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D313727at33208
OrthoFinder	1	1.000	-	-		FOG0000271
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19850
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X182
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920