Protein Alignment tey and RNF220

DIOPT Version :9

• Sequence 1: NP_001137981.1
• Gene: tey / 40146
• FlyBaseID: FBgn0036899
• Length: 822
• Species: Drosophila melanogaster
• Sequence 2: NP_001363415.1
• Gene: RNF220 / 55182
• HGNCID: 25552
• Length: 592
• Species: Homo sapiens
• Alignment Length: 673
• Identity: 143/673 - (21%)
• Similarity: 209/673 - (31%)
• Gaps: 252/673 - (37%)

  Fly   173 NNSQDPRDLRHLHNAGKSHQALATSSSASSSSSSSCSTSNPAISTATSSVAVSM----------A 227
            |:|..|..|     |..:...||:::.||..:|..|....|      ..|.||:          .
Human    12 NSSYLPNPL-----ASPALMVLASTAEASRDASIPCQQPRP------FGVPVSVDKDVHIPFTNG 65

  Fly   228 SHLAASSPHHH---PHTHAHS-------HPHP-LAHPHAHSH-----HHVGHHVGA--PPVST-- 272
            |:..||..|..   |.|.|:.       |.|| .|.|:....     :|.|  |||  |..||
Human    66 SYTFASMYHRQGGVPGTFANRDFPPSLLHLHPQFAPPNLDCTPISMLNHSG--VGAFRPFASTED 128

  Fly   273 ------AVTTHHHMAHPHPLSHHHAAHHAA----------LASLSMAGLRAVPGGLSL--VSGLQ 319
                  |.|....:.:.|.....|.....|          |.|.|...|:....|..:  ||||.
Human   129 RESYQSAFTPAKRLKNCHDTESPHLRFSDADGKEYDFGTQLPSSSPGSLKVDDTGKKIFAVSGLI 193

  Fly   320 AAAAGGAIPE-------------------MCPVCGLKLSAEEWHTHFLTELDRLYKLSAGFERAS 365
            :.....:.||                   :||:|.:.|...|...|...||::|.:|.:  .:.|
Human   194 SDREASSSPEDRNDRCKKKAAALFDSQAPICPICQVLLRPSELQEHMEQELEQLAQLPS--SKNS 256

  Fly   366 LQATYMFAPPCPAQ-----------ENAIRTSH----------NRWETFQRIRNNRQNRL----- 404
            |....| ||..|..           |:...:.|          :|::||.|:|.|||.||
Human   257 LLKDAM-APGTPKSLLLSASIKREGESPTASPHSSATDDLHHSDRYQTFLRVRANRQTRLNARIG 320

  Fly   405 RLKVRKRKYGEMYMMESLYCSSCPICKRKYALETGKIPPEDDAKSQEEIETVDVESCNDEVPDSG 469
            ::|.||:..|::          ||:|.|..            |.|::|:.. .||.|
Human   321 KMKRRKQDEGQV----------CPLCNRPL------------AGSEQEMSR-HVEHC-------- 354

  Fly   470 SELATPSSGSSGTVMPPSSMHNSNSQPGKLDGILYRTGCVLSQKDPHPDEHDVSTNVTTASSSSW 534
                                            :..|.|..:::.|....||:   |........|
Human   355 --------------------------------LSKREGSCMAEDDAVDIEHE---NNNRFEEYEW 384

  Fly   535 PGEAPTQAHISVKTVSELSSTTHHYYNADSCGVGVNDTNSSSSTHNNGGGSNKDLMMDTASCQND 599
            .|    |..|...|:.|                              ||......:|.:.....|
Human   385 CG----QKRIRATTLLE------------------------------GGFRGSGFIMCSGKENPD 415

  Fly   600 SDEDVIVDDDDTVKLTSKINYGKIQRRQDE------QNVGSSRSLE-------NISPVEER--PR 649
            ||.|:.||.|||      :.|||.|..:.:      :..|.::..|       |..|...|  |.
Human   416 SDADLDVDGDDT------LEYGKPQYTEADVIPCTGEEPGEAKEREALRGAVLNGGPPSTRITPE 474

  Fly   650 SEPQVSSTEPGPMDISHNNNNNNNNNNNNSNSNNNNNPSTKYAESMENS-LSQLS-SMGVPGLTQ 712
            .....|...|                   |.||..::......::.:|| :.::: ...|.....
Human   475 FSKWASDEMP-------------------STSNGESSKQEAMQKTCKNSDIEKITEDSAVTTFEA 520

  Fly   713 LDTKV-GISSDLKPDDENKCFIC 734
            |..:| .:...|...|..||.||
Human   521 LKARVRELERQLSRGDRYKCLIC 543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tey	NP_001137981.1	RNF220	328..>459	CDD:292548	41/175 (23%)
RNF220	NP_001363415.1	RNF220	219..468	CDD:374229	74/357 (21%)
		RING-HC_RNF220	539..579	CDD:319477	4/5 (80%)
		RING-HC finger (C3HC4-type)	540..578	CDD:319477	3/4 (75%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159886
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28IQH
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR13459
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.930