DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf146 and RNF146

DIOPT Version :9

Sequence 1:	NP_001137978.1	Gene:	Rnf146 / 40144	FlyBaseID:	FBgn0036897	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001229778.1	Gene:	RNF146 / 81847	HGNCID:	21336	Length:	359	Species:	Homo sapiens

Alignment Length:	324	Identity:	124/324 - (38%)
Similarity:	183/324 - (56%)	Gaps:	28/324 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 DSPSAAAAAL---ECPICLQTCIHPARLPCGHIFCFLCVKGVAYKNRRCAMCRREIPAEFLDHPQ 174
            :|.|..|.:|   ||.||||||:||..|||.|:||:|||||.::..:|||:||:|||.:|||.|.
Human    23 ESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPT 87

  Fly   175 LVNGIEDICTTRATEDGFQWYYEGRNGWWQYDDRTSQDIEDAFKKGDKSCTILVAGYVYIVDLEQ 239
            |::..|....:|...: :.|||||||||||||:|||:::||||.||.|:..:|:||::|:.|||.
Human    88 LLSPEELKAASRGNGE-YAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLEN 151

  Fly   240 LVQQRQNEPTRCRRVKRDLATIPKKGVAGLRIEGNQVTSDTVFSRPTNTANPTTVAAAAS----- 299
            :||.|:||..|.|::|||:..||||||||||::.:..|.:.......:.|:..:..:.||
Human   152 MVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCDANTVNLARESSADGADSVSAQSGASVQPLV 216

  Fly   300 SFISTIAATDAAIRI-------ASDIIGSTLAHADELTRGLTASNLNDDLSSSGEQSNSTNSNDA 357
            |.:..:.:.|..:..       ||..:..:.||. :|:...||     :.|..||......|..:
Human   217 SSVRPLTSVDGQLTSPATPSPDASTSLEDSFAHL-QLSGDNTA-----ERSHRGEGEEDHESPSS 275

  Fly   358 GRSPASSPASSSMQDLITRDLRNTQQVIAHNQHTIDLFEQALNDFQALAMRNYVDSSDEENNDQ 421
            ||.||...:....:...:.|..:...|:|  ||:  |.:|.|  ..:.|.:...|.||....|:
Human   276 GRVPAPDTSIEETESDASSDSEDVSAVVA--QHS--LTQQRL--LVSNANQTVPDRSDRSGTDR 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf146	NP_001137978.1	RING	123..165	CDD:238093	26/41 (63%)
Rnf146	NP_001137978.1	WWE	192..264	CDD:128922	42/71 (59%)
RNF146	NP_001229778.1	RING-HC_RNF146	36..75	CDD:319460	24/38 (63%)
		RING-HC finger (C3HC4-type)	37..74	CDD:319460	23/36 (64%)
		WWE	104..176	CDD:128922	42/71 (59%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	254..359		23/91 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147395
Domainoid	1	1.000	98	1.000	Domainoid score	I7203
eggNOG	1	0.900	-	-		E1_KOG0824
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3653
Isobase	1	0.950	-	0	Normalized mean entropy	S5209
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004614
OrthoInspector	1	1.000	-	-		oto88724
orthoMCL	1	0.900	-	-		OOG6_107506
Panther	1	1.100	-	-	LDO	PTHR13417
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2954
SonicParanoid	1	1.000	-	-		X3820
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.730