DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf146 and Rnf146

DIOPT Version :9

Sequence 1:	NP_001137978.1	Gene:	Rnf146 / 40144	FlyBaseID:	FBgn0036897	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_001103666.1	Gene:	Rnf146 / 68031	MGIID:	1915281	Length:	359	Species:	Mus musculus

Alignment Length:	330	Identity:	128/330 - (38%)
Similarity:	183/330 - (55%)	Gaps:	41/330 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 DSPSAAAAAL---ECPICLQTCIHPARLPCGHIFCFLCVKGVAYKNRRCAMCRREIPAEFLDHPQ 174
            :|.|..|.:|   ||.||||||:||..|||.|:||:|||||.::..:|||:||:|||.:|||.|.
Mouse    24 ESCSNTAPSLTVPECAICLQTCVHPVSLPCKHVFCYLCVKGASWLGKRCALCRQEIPEDFLDKPT 88

  Fly   175 LVNGIEDICTTRATEDGFQWYYEGRNGWWQYDDRTSQDIEDAFKKGDKSCTILVAGYVYIVDLEQ 239
            |::..|....:|...: :.|||||||||||||:|||:::||||.||.|:..:|:||::|:.|||.
Mouse    89 LLSPEELKAASRGNGE-YAWYYEGRNGWWQYDERTSRELEDAFSKGKKNTEMLIAGFLYVADLEN 152

  Fly   240 LVQQRQNEPTRCRRVKRDLATIPKKGVAGLRIEGNQVTSDTVFSRPTNTANPTTVAAAASSFIST 304
            :||.|:||..|.|::|||:..||||||||||::.:           |||.| ....::|....|.
Mouse   153 MVQYRRNEHGRRRKIKRDIIDIPKKGVAGLRLDCD-----------TNTVN-LARESSADGADSG 205

  Fly   305 IAATDAAIRIASDIIGSTLAHAD-ELTRGLTAS-----NLNDD---LSSSGEQSNSTNSNDAGRS 360
            .|.|.|::::|.......|...| :||..:|.|     :|.|.   |..||:.....:....|..
Mouse   206 SAQTGASVQLAVPSSTRPLTSVDGQLTSPVTPSPDAGISLEDSFAHLQLSGDSIAERSHRGEGEE 270

  Fly   361 PASSPASSSMQDL--------ITRDLRNTQQVIAHNQHTIDLFEQAL-NDFQALAMRNYVDSSDE 416
            ...||:|..:.|.        .:.|..:...|:|  ||::......: |..|.:|     |.||.
Mouse   271 DHESPSSGRVPDTSVEETESDASSDSEDAPVVVA--QHSLTQQRPLVPNGNQTVA-----DQSDR 328

  Fly   417 ENNDQ 421
            ...|:
Mouse   329 SGTDR 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf146	NP_001137978.1	RING	123..165	CDD:238093	26/41 (63%)
Rnf146	NP_001137978.1	WWE	192..264	CDD:128922	42/71 (59%)
Rnf146	NP_001103666.1	RING	37..79	CDD:238093	27/41 (66%)
		WWE	105..177	CDD:128922	44/71 (62%)
		PAR-binding	144..167		11/22 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	197..243		14/46 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	261..359		17/81 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837326
Domainoid	1	1.000	98	1.000	Domainoid score	I7203
eggNOG	1	0.900	-	-		E1_KOG0824
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	210	1.000	Inparanoid score	I3664
Isobase	1	0.950	-	0	Normalized mean entropy	S5209
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004614
OrthoInspector	1	1.000	-	-		oto92292
orthoMCL	1	0.900	-	-		OOG6_107506
Panther	1	1.100	-	-	LDO	PTHR13417
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2954
SonicParanoid	1	1.000	-	-		X3820
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.730