DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rnf146 and C26B9.6

DIOPT Version :9

Sequence 1:	NP_001137978.1	Gene:	Rnf146 / 40144	FlyBaseID:	FBgn0036897	Length:	448	Species:	Drosophila melanogaster
Sequence 2:	NP_508904.2	Gene:	C26B9.6 / 182932	WormBaseID:	WBGene00016135	Length:	306	Species:	Caenorhabditis elegans

Alignment Length:	191	Identity:	49/191 - (25%)
Similarity:	84/191 - (43%)	Gaps:	45/191 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   124 CPICLQTCIHPARLP-CGHIFCFLCVKGVAYKNRRCAMCRREI-PAEF-------LD-HPQLVNG 178
            |.||......|.|:. |||.||::|:|........|.:||.:| |:.|       || |.|....
Worm   107 CYICYYKLTIPTRIENCGHEFCYVCLKSNFAMGNDCPVCRGKISPSLFSMPIRYDLDIHMQCPED 171

  Fly   179 IEDIC----------------------------TTRATEDGFQWYYEGRN-GWWQYDDRTSQDIE 214
            ..|.|                            :.|.|.:.:.|.||..: |:::||.:..:.:|
Worm   172 YADECADMVDRDHFRKSYIKGQEPTKSKPTLRRSKRTTREKYYWIYESSSFGYYRYDPKDEKYLE 236

  Fly   215 DAFKKGDKSCTILVAGYVYIVDLEQLVQQRQNEPTRC--RRVKRDLAT-IPK---KGVAGL 269
            :.:.:..::|.:.:.|...:::::..||::.....||  |::.|..|| |.|   ||:||:
Worm   237 ECYCRKMETCVMRICGTAMLINIKDGVQEQVENEVRCTRRKILRIKATEIEKYNIKGIAGI 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rnf146	NP_001137978.1	RING	123..165	CDD:238093	15/41 (37%)
Rnf146	NP_001137978.1	WWE	192..264	CDD:128922	19/78 (24%)
C26B9.6	NP_508904.2	WWE	10..83	CDD:128922
		RING	107..149	CDD:238093	15/41 (37%)
		WWE	213..288	CDD:128922	18/74 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	47	1.000	Domainoid score	I8091
eggNOG	1	0.900	-	-		E1_KOG0824
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5209
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004614
OrthoInspector	1	1.000	-	-		otm14634
orthoMCL	1	0.900	-	-		OOG6_107506
Panther	1	1.100	-	-	O	PTHR13417
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760