DRSC/TRiP Functional Genomics Resources

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Protein Alignment wnd and MAP3K13

DIOPT Version :9

Sequence 1:NP_649137.3 Gene:wnd / 40143 FlyBaseID:FBgn0036896 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_001229243.1 Gene:MAP3K13 / 9175 HGNCID:6852 Length:966 Species:Homo sapiens


Alignment Length:1053 Identity:378/1053 - (35%)
Similarity:509/1053 - (48%) Gaps:238/1053 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 PFSDSLSKSRDDLVTAASRQQQQLHGRRRHHGSSPNLSLDQTDN--LRRSMACLQDEFGHLGIAA 65
            |||:  ||:.:.|       |.:|.....|  .||.|..||.:.  :|..:.    |..|..:..
Human    17 PFSE--SKTFNGL-------QDELTAMGNH--PSPKLLEDQQEKGMVRTELI----ESVHSPVTT 66

  Fly    66 TDLPFKSSDLDSPPRLQHHNNYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPI--------- 121
            |.|...|.|    .|.|..|:..::.:.....|...:...:.....:..|..|..|         
Human    67 TVLTSVSED----SRDQFENSVLQLREHDESETAVSQGNSNTVDGESTSGTEDIKIQFSRSGSGS 127

  Fly   122 -GWMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETV 185
             |::.||.||::||.:.|||....:.|.|:.:.|::|||.|:||:|||||||||||.|:.:.|.|
Human   128 GGFLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEV 192

  Fly   186 AVKKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLV 250
            |:|||:|..||||||||||.|.|||.|||||||:|.:|||||:|.:|.|..:|:..:.:.|..||
Human   193 AIKKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLV 257

  Fly   251 SWSKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAP 315
            .||..||.||.|||.||||||||||||:|::..:.|||||||||:|.::.|||||||||||||||
Human   258 DWSTGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAP 322

  Fly   316 EVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVK 380
            |||||||.||||||||:||||||:||.|||||||||||||||||:|||.|.||||||:|||:|:|
Human   323 EVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMK 387

  Fly   381 LCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQ 445
            ..|:|||||||||||.|.|||||..::|...::.||::|..|:|||:.|.::|...||.||:.::
Human   388 QTWQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDE 452

  Fly   446 DLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAER----ERKLPGSGYK 506
            :||:||..|.|||.|||..||.||::.|.|:.|||..|.||:.:|||:.:|    |:|.||: ||
Human   453 ELIRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELIKREQAVEKKYPGT-YK 516

  Fly   507 --PNRRF--GNTIRKMQHYRRRLNPAPAAIQ-------QQSTTPDPETTPESPVKCMLYAQLDSN 560
              |.|..  .|.:.|:.  :|:..|..:.:|       :....|..|..|.:.            
Human   517 RHPVRPIIHPNAMEKLM--KRKGVPHKSGMQTKRPDLLRSEGIPTTEVAPTAS------------ 567

  Fly   561 CQPKSYLANIIPSSGLGAPMPNKNKKVF----RHRR-NASGS---FGAPPKYSPTRD-------- 609
                       |.||......:.:|..:    |||| |:.||   |.|..|..|.::        
Human   568 -----------PLSGSPKMSTSSSKSRYRSKPRHRRGNSRGSHSDFAAILKNQPAQENSPHPTYL 621

  Fly   610 -----------------RRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPR----SQPID 653
                             ::||..|.      ...|:....:::...||:..|...|    :..:.
Human   622 HQAQSQYPSLHHHNSLQQQYQQPPP------AMSQSHHPRLNMHGQDIATCANNLRYFGPAAALR 680

  Fly   654 VPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNP--ACPSNGNSLSTSELTYQDAC--S 714
            .|:.||.|..|.......|:.|.|.....|:....|...|  .|.::.          .|.|  .
Human   681 SPLSNHAQRQLPGSSPDLISTAMAADCWRSSEPDKGQAGPWGCCQADA----------YDPCLQC 735

  Fly   715 SPDQLIDDVMNSNERL----DMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNG 775
            .|:|.....:.|.|.:    |:::..:.|..||               :.||:..:..|..:|..
Human   736 RPEQYGSLDIPSAEPVGRSPDLSKSPAHNPLLE---------------NAQSSEKTEENEFSGCR 785

  Fly   776 GASPLELRESGNSPCLSRCSSTHSKRRKHPL---GDNPNGSSIGNANGESHEQDSWSDEEGETTD 837
            ..|.|.....|..|.|        .|:..||   ||                 ||..:|||| .|
Human   786 SESSLGTSHLGTPPAL--------PRKTRPLQKSGD-----------------DSSEEEEGE-VD 824

  Fly   838 YKYALRRRSIGRQPIARGMRPRR------SYKAPLSQKIAIHKRNVVIVSD-EEENTSEYSHSPS 895
            .:....||          .||.|      ||....|:..:        ||| ||.|||::|:||.
Human   825 SEVEFPRR----------QRPHRCISSCQSYSTFSSENFS--------VSDGEEGNTSDHSNSPD 871

  Fly   896 SQHSTLE----------------------SNTD-IADMK------KTQAT----STSSNSYSEP- 926
            .....||                      |::| ::|.:      |||.:    ......|..| 
Human   872 ELADKLEDRLAEKLDDLLSQTPEIPIDISSHSDGLSDKECAVRRVKTQMSLGKLCVEERGYENPM 936

  Fly   927 --EDDSSDSSDEE 937
              |:...||||.|
Human   937 QFEESDCDSSDGE 949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wndNP_649137.3 STYKc 161..400 CDD:214568 171/238 (72%)
STKc_MAP3K12_13 167..403 CDD:270961 170/235 (72%)
MAP3K13NP_001229243.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22 3/6 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 30..49 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..114 2/23 (9%)
STYKc 168..402 CDD:214568 168/233 (72%)
STKc_MAP3K12_13 174..410 CDD:270961 170/235 (72%)
Leucine-zipper 1 433..454 7/20 (35%)
Leucine-zipper 2 486..507 9/20 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 534..599 16/87 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 611..655 4/49 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..834 29/140 (21%)
Acidic. /evidence=ECO:0000305 815..828 6/13 (46%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 846..908 16/69 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 358 1.000 Domainoid score I973
eggNOG 1 0.900 - - E1_KOG4721
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 507 1.000 Inparanoid score I1339
Isobase 1 0.950 - 0 Normalized mean entropy S2281
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003049
OrthoInspector 1 1.000 - - otm40729
orthoMCL 1 0.900 - - OOG6_105153
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2490
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1110.700

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