Protein Alignment wnd and Mlkl

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001297542.1
• Gene: Mlkl / 74568
• MGIID: 1921818
• Length: 472
• Species: Mus musculus
• Alignment Length: 262
• Identity: 73/262 - (27%)
• Similarity: 126/262 - (48%)
• Gaps: 25/262 - (9%)

  Fly   155 QIPFESITELEW--LGSGAQGAVFSGRLKNETVAVKK-----------VKELKETDIKHLRKLDH 206
            :||.|.:.. .|  |.:.....::.|......|.:|.           |:.....:||.::|.|.
Mouse   185 EIPKEHLGP-PWTKLKTSKMSTIYRGEYHRSPVTIKVFNNPQAESVGIVRFTFNDEIKTMKKFDS 248

  Fly   207 ENIIKFKGVC----TQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHK 267
            .||::..|:|    .:.|.|.|:||:|..|.|:.:|..|:.:..|.......:.|.|:..||..:
Mouse   249 PNILRIFGICIDQTVKPPEFSIVMEYCELGTLRELLDREKDLTMSVRSLLVLRAARGLYRLHHSE 313

  Fly   268 IIHRDLKSPNILISTNEVVKISDFGTSREWNEI-----STKMSFAGTVAWMAPEVIRNEPC--SE 325
            .:||::.|.:.|::....||::.|..|:..|.|     |||...:.:..:::||.::|..|  ..
Mouse   314 TLHRNISSSSFLVAGGYQVKLAGFELSKTQNSISRTAKSTKAERSSSTIYVSPERLKNPFCLYDI 378

  Fly   326 KVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNR 390
            |.:|:|:|:||||:.|.:||::..||..|...|..:..:..|...|||..:.::..|...:|..|
Mouse   379 KAEIYSFGIVLWEIATGKIPFEGCDSKKIRELVAEDKKQEPVGQDCPELLREIINECRAHEPSQR 443

  Fly   391 PS 392
            ||
Mouse   444 PS 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	69/248 (28%)
Mlkl	NP_001297542.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000250|UniProtKB:Q8NB16	1..143
		MLKL_NTD	5..143	CDD:411030
		COG7	130..>179	CDD:431125
		Protein Kinases, catalytic domain	198..446	CDD:473864	69/248 (28%)