DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wnd and Map3k13

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_766409.2	Gene:	Map3k13 / 71751	MGIID:	2444243	Length:	959	Species:	Mus musculus

Alignment Length:	1059	Identity:	385/1059 - (36%)
Similarity:	513/1059 - (48%)	Gaps:	277/1059 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 TAASRQQQQLHGRRRHHGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLDS---P 78
            |:..|.:....|..    .||.|..|..:.     ..:|.|.    :..|..|..::.|.|   .
Mouse    23 TSGGRNELAAMGNH----PSPKLPEDPQER-----GAIQSEL----MEITGSPISTTVLTSVSED 74

  Fly    79 PRLQHHNNYAEITDS---------------SAENTCQQRWPPHV------GGAGAAFGHPDKPIG 122
            .|.|..|:..::.:.               ..|||   ..|..:      .|:|:.        |
Mouse    75 SRGQFENSVLQLREQDESEMTLSLGNSNTVDGENT---NGPEDIKIQFSRSGSGSG--------G 128

  Fly   123 WMYGLLGCMKPVLSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAV 187
            ::.||.||::||.:.|||....:.|.|:.:.|::|||.|:||:|||||||||||.|:.:.|.||:
Mouse   129 FLEGLFGCLRPVWNIIGKAYSTDYKLQQQDTWEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAI 193

  Fly   188 KKVKELKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSW 252
            |||:|..||||||||||.|.|||.|||||||:|.:|||||:|.:|.|..:|:..:.:.|..||.|
Mouse   194 KKVREQNETDIKHLRKLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITPRLLVDW 258

  Fly   253 SKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSREWNEISTKMSFAGTVAWMAPEV 317
            |..||.||.|||.||||||||||||:|::..:.|||||||||:|.::.|||||||||||||||||
Mouse   259 STGIASGMNYLHLHKIIHRDLKSPNVLVTHTDAVKISDFGTSKELSDKSTKMSFAGTVAWMAPEV 323

  Fly   318 IRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLC 382
            |||||.||||||||:||||||:||.|||||||||||||||||:|||.|.||||||:|||:|:|..
Mouse   324 IRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQT 388

  Fly   383 WKSKPRNRPSFRQILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTNIHKYEQDL 447
            |:|||||||||||.|.|||||..::|...::.||::|..|:|||:.|.::|...||.||:.:::|
Mouse   389 WQSKPRNRPSFRQTLMHLDIASADVLATPQETYFKSQAEWREEVKKHFEKIKSEGTCIHRLDEEL 453

  Fly   448 IKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAER----ERKLPGSGYK-- 506
            |:||..|.|||.|||..||.||::.|.|:.|||..|.||:.:|||:.:|    |:|.||: ||
Mouse   454 IRRRREELRHALDIREHYERKLERANNLYMELSAIMLQLEMREKELLKREQAVEKKYPGT-YKRH 517

  Fly   507 PNRRF--GNTIRKMQHYRRRLNPAPAAIQQQSTTPDPETTPESPVKCMLYAQLDSNCQPKSYLAN 569
            |.|..  .|.:.|:.  :|:..|..|.:  |:..||               .|.|...|.:   .
Mouse   518 PVRPIIHPNAMEKLM--KRKGVPHKAGV--QTKRPD---------------LLRSEGIPST---E 560

  Fly   570 IIPSSGLGAPMPNKNKKVFRHRRNASGSFGAPPKYSPTRDR-RYQSEPENRKVQLVERQTQTDAM 633
            .:|::   :|:              |||    ||.|....| ||:|:|.:|:..  .|.:.:|..
Mouse   561 AVPTA---SPL--------------SGS----PKMSTASSRSRYRSKPRHRRGN--SRGSHSDFA 602

  Fly   634 DVSETDISPSAEAPRSQPIDVPVPN------------HRQLPLQLQRVQKIAQAQARARSGSTSS 686
            .:.:|  .|:.|       :.|.|.            |:..||| |:.|:|..||.::|
Mouse   603 AILKT--QPAQE-------NSPHPTYMHHTQAQCASVHQHNPLQ-QQYQQIPPAQPQSR------ 651

  Fly   687 AAGAVNPACPSNGNSLST--SELTY-----------------QDACSSPDQLIDDVMNS---NER 729
                 :|...::|..::|  :.|.|                 |...|||| ||...|.:   |..
Mouse   652 -----HPRLNAHGQDIATCANNLRYFGPAAALRSPLSNHAQRQMPGSSPD-LISTAMAADWRNSE 710

  Fly   730 LDMTE-----CCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGASPLELRESGNSP 789
            ||..:     ||.....     ....:...|:..|:...|            ..|:     |.||
Mouse   711 LDQDQVGPWGCCQAEPY-----DPCFQCRPEHSGSLDVPT------------TEPV-----GRSP 753

  Fly   790 CLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQ-----------------------DSWSDE 831
            .|| .|..|     :||..|..||....|||.|..|                       |..|:|
Mouse   754 DLS-SSPAH-----NPLSGNAQGSERTGANGFSGCQSGISHQFTPPMLPQKTRPLQKSGDDSSEE 812

  Fly   832 EGETTDYKYALRRRSIGRQPIARGMRPRR------SYKAPLSQKIAIHKRNVVIVSD-EEENTSE 889
            ||| .|.:....||          .||.|      ||....|:..:        ||| ||.|||:
Mouse   813 EGE-VDSEVEFPRR----------QRPHRCISSYQSYSTFSSENFS--------VSDGEEGNTSD 858

  Fly   890 YSHSPS----------------------------SQHSTLESNTDIADMK-KTQAT----STSSN 921
            :|:||.                            |.||...|:.:.|..: |||.:    .....
Mouse   859 HSNSPDESANRRQDRLAETLDDLLSQTPEAPIEISSHSDGLSDKECAVRRVKTQMSLGKLCAEER 923

  Fly   922 SYSEP---EDDSSDSSDEE 937
            .|..|   .|...|||:.|
Mouse   924 GYENPVQFGDSDCDSSEGE 942

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	171/238 (72%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	170/235 (72%)
Map3k13	NP_766409.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		7/27 (26%)
		STKc_MAP3K12_13	173..409	CDD:270961	170/235 (72%)
		Leucine-zipper 1	432..453		7/20 (35%)
		Leucine-zipper 2	485..506		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	533..599		24/108 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	739..828		29/122 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	842..902		16/67 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..959		6/16 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	358	1.000	Domainoid score	I964
eggNOG	1	0.900	-	-		E1_KOG4721
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	508	1.000	Inparanoid score	I1319
Isobase	1	0.950	-	0	Normalized mean entropy	S2281
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		otm42802
orthoMCL	1	0.900	-	-		OOG6_105153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2490
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700