DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment wnd and BTK

DIOPT Version :9

Sequence 1:NP_649137.3 Gene:wnd / 40143 FlyBaseID:FBgn0036896 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_001274273.1 Gene:BTK / 695 HGNCID:1133 Length:693 Species:Homo sapiens


Alignment Length:266 Identity:89/266 - (33%)
Similarity:144/266 - (54%) Gaps:15/266 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   154 WQIPFESITELEWLGSGAQGAVFSGRLKNE-TVAVKKVKE--LKETDI----KHLRKLDHENIIK 211
            |:|..:.:|.|:.||:|..|.|..|:.:.: .||:|.:||  :.|.:.    |.:..|.||.:::
Human   429 WEIDPKDLTFLKELGTGQFGVVKYGKWRGQYDVAIKMIKEGSMSEDEFIEEAKVMMNLSHEKLVQ 493

  Fly   212 FKGVCT-QSPVFCIIMEFCPYGPLQNILKEEQVMLPS-RLVSWSKQIALGMQYLHSHKIIHRDLK 274
            ..|||| |.|:| ||.|:...|.|.|.|:|.:....: :|:...|.:...|:||.|.:.:||||.
Human   494 LYGVCTKQRPIF-IITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLA 557

  Fly   275 SPNILISTNEVVKISDFGTSREW--NEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLW 337
            :.|.|::...|||:||||.||..  :|.::.:.....|.|..|||:.....|.|.|||::||::|
Human   558 ARNCLVNDQGVVKVSDFGLSRYVLDDEYTSSVGSKFPVRWSPPEVLMYSKFSSKSDIWAFGVLMW 622

  Fly   338 EMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSH-L 400
            |:.:. ::||:...:|.....:. ..|:|..|....|....::..||..|...||:|:.:||: |
Human   623 EIYSLGKMPYERFTNSETAEHIA-QGLRLYRPHLASEKVYTIMYSCWHEKADERPTFKILLSNIL 686

  Fly   401 DIAGPE 406
            |:...|
Human   687 DVMDEE 692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wndNP_649137.3 STYKc 161..400 CDD:214568 84/251 (33%)
STKc_MAP3K12_13 167..403 CDD:270961 84/248 (34%)
BTKNP_001274273.1 PH 38..167 CDD:278594
PH_Btk 40..200 CDD:269944
SH3_BTK 251..305 CDD:212839
SH2_Tec_Btk 308..413 CDD:198260
PTKc_Btk_Bmx 431..686 CDD:173657 85/256 (33%)
Pkinase_Tyr 436..685 CDD:285015 84/250 (34%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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