Protein Alignment wnd and MAP3K7

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_663304.1
• Gene: MAP3K7 / 6885
• HGNCID: 6859
• Length: 606
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 159/658 - (24%)
• Similarity: 261/658 - (39%)
• Gaps: 185/658 - (28%)

  Fly   143 VIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKE-----TDIKHLR 202
            :||..||.....:|.::.|...|.:|.||.|.|...:.:.:.||:|:::...|     .:::.|.
Human    18 MIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLS 82

  Fly   203 KLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLP----SRLVSWSKQIALGMQYL 263
            :::|.||:|..|.|. :|| |::||:...|.|.|:|...: .||    :..:||..|.:.|:.||
Human    83 RVNHPNIVKLYGACL-NPV-CLVMEYAEGGSLYNVLHGAE-PLPYYTAAHAMSWCLQCSQGVAYL 144

  Fly   264 HSHK---IIHRDLKSPN-ILISTNEVVKISDFGTSREWNEISTKM-SFAGTVAWMAPEVIRNEPC 323
            ||.:   :||||||.|| :|::...|:||.||||:   .:|.|.| :..|:.|||||||......
Human   145 HSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTA---CDIQTHMTNNKGSAAWMAPEVFEGSNY 206

  Fly   324 SEKVDIWSYGVVLWEMLTCEIPYKDVDSSA--IIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSK 386
            |||.|::|:|::|||::|...|:.::...|  |:|.|.|.:...|: ...|:..:.|:..||...
Human   207 SEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLI-KNLPKPIESLMTRCWSKD 270

  Fly   387 PRNRPSFRQIL------------------------------------SHLDIAGPELLRKTEKQY 415
            |..|||..:|:                                    |.:|||......|::
Human   271 PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSD--- 332

  Fly   416 FETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDI-----RMVYEDKLQKTNQL 475
                        ::::::......|.:.|..|:|.:..:...:..:     |....:.|..|:
Human   333 ------------TNMEQVPATNDTIKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTS-- 383

  Fly   476 FFELSECMSQLQEKEKEIAERER-KLPGSGYKPNRRFGN-------TIRKMQHYRRR-------L 525
              |.....:.:.|.|..||.... ..|..|::....|||       .|......|||       .
Human   384 --EGKRMSADMSEIEARIAATTAYSKPKRGHRKTASFGNILDVPEIVISGNGQPRRRSIQDLTVT 446

  Fly   526 NPAPAAIQQQSTTPDPE------TTPESPVKC-------------------MLYAQLDSNCQPKS 565
            ...|..:..:|::|...      .|.|.|.:.                   |.|..||...||.
Human   447 GTEPGQVSSRSSSPSVRMITTSGPTSEKPTRSHPWTPDDSTDTNGSDNSIPMAYLTLDHQLQPL- 510

  Fly   566 YLANIIPSSGLGAPMPNKNKK--VF-RHRRNASGSFGAPPKYSPTRDRRYQSEPENRKVQ----- 622
                        ||.||..:.  || :|.:.|.                     |..|||
Human   511 ------------APCPNSKESMAVFEQHCKMAQ---------------------EYMKVQTEIAL 542

  Fly   623 LVERQTQTDA-MDVSETDISPSAEAPRSQPIDVPVPNHRQL----------PLQLQRVQKIAQAQ 676
            |::|:.:..| :|..|.|         .|.....|..|::|          ..|.::..::.::|
Human   543 LLQRKQELVAELDQDEKD---------QQNTSRLVQEHKKLLDENKSLSTYYQQCKKQLEVIRSQ 598

  Fly   677 ARARSGST 684
            .:.|.|::
Human   599 QQKRQGTS 606

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	90/287 (31%)
MAP3K7	NP_663304.1	Interaction with MAPK8IP1. /evidence=ECO:0000250	1..300		95/288 (33%)
		STKc_TAK1	42..292	CDD:270960	88/256 (34%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	301..338		5/51 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	354..391		5/40 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	443..493		6/49 (12%)