DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wnd and SRMS

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_543013.1	Gene:	SRMS / 6725	HGNCID:	11298	Length:	488	Species:	Homo sapiens

Alignment Length:	267	Identity:	85/267 - (31%)
Similarity:	132/267 - (49%)	Gaps:	15/267 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   147 KSQRSEDWQIPFESITELEWLGSGAQGAVFSGR-LKNETVAVKKVK--ELKETD----IKHLRKL 204
            |:.|.:.|:.|.........||.|..|.|:.|. |.:..||:|.:|  .:|.||    |:.|:.|
Human   216 KAPRQDVWERPHSEFALGRKLGEGYFGEVWEGLWLGSLPVAIKVIKSANMKLTDLAKEIQTLKGL 280

  Fly   205 DHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNIL---KEEQVMLPSRLVSWSKQIALGMQYLHSH 266
            .||.:|:...||:......|:.|....|.||..|   :...:.||. |:.::.|:|.||.||...
Human   281 RHERLIRLHAVCSGGEPVYIVTELMRKGNLQAFLGTPEGRALRLPP-LLGFACQVAEGMSYLEEQ 344

  Fly   267 KIIHRDLKSPNILISTNEVVKISDFGTSREWNE--ISTKMSFAGTVAWMAPEVIRNEPCSEKVDI 329
            :::||||.:.|:|:......|::|||.:|...:  .|...|....|.|.|||.......|:|.|:
Human   345 RVVHRDLAARNVLVDDGLACKVADFGLARLLKDDIYSPSSSSKIPVKWTAPEAANYRVFSQKSDV 409

  Fly   330 WSYGVVLWEMLTC-EIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSF 393
            ||:||:|.|:.|. :.||:.:.:...:..: ....:|..|:.||....:|:..||:|.|..||||
Human   410 WSFGVLLHEVFTYGQCPYEGMTNHETLQQI-MRGYRLPRPAACPAEVYVLMLECWRSSPEERPSF 473

  Fly   394 RQILSHL 400
            ..:...|
Human   474 ATLREKL 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	80/251 (32%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	81/247 (33%)
SRMS	NP_543013.1	SH3_Srms	55..109	CDD:212780
		SH2	119..197	CDD:301589
		PTKc_Srm_Brk	223..483	CDD:133248	83/260 (32%)
		STYKc	232..480	CDD:214568	80/249 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910