DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wnd and SRC

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_016883513.1	Gene:	SRC / 6714	HGNCID:	11283	Length:	542	Species:	Homo sapiens

Alignment Length:	296	Identity:	91/296 - (30%)
Similarity:	150/296 - (50%)	Gaps:	24/296 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   135 LSFIGKTGVIEVKSQRSEDWQIPFESITELEWLGSGAQGAVFSGRLKNET-VAVKKVKE------ 192
            |:.:..|...:.:....:.|:||.||:.....||.|..|.|:.|.....| ||:|.:|.
Human   250 LTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPE 314

  Fly   193 --LKETDIKHLRKLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEE---QVMLPSRLVSW 252
              |:|..:  ::||.||.:::...|.::.|:: |:.|:...|.|.:.||.|   .:.|| :||..
Human   315 AFLQEAQV--MKKLRHEKLVQLYAVVSEEPIY-IVTEYMSKGSLLDFLKGETGKYLRLP-QLVDM 375

  Fly   253 SKQIALGMQYLHSHKIIHRDLKSPNILISTNEVVKISDFGTSR--EWNEISTKMSFAGTVAWMAP 315
            :.|||.||.|:.....:||||::.|||:..|.|.|::|||.:|  |.||.:.:......:.|.||
Human   376 AAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAP 440

  Fly   316 EVIRNEPCSEKVDIWSYGVVLWEMLT-CEIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLV 379
            |.......:.|.|:||:|::|.|:.| ..:||..:.:..::..| ....::..|..|||....|:
Human   441 EAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQV-ERGYRMPCPPECPESLHDLM 504

  Fly   380 KLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQY 415
            ..||:.:|..||:|..:.:.|:    :....||.||
Human   505 CQCWRKEPEERPTFEYLQAFLE----DYFTSTEPQY 536

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	79/253 (31%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	80/250 (32%)
SRC	XP_016883513.1	SH3_Src	88..149	CDD:212941
		SH2_Src_Src	153..253	CDD:198228	1/2 (50%)
		PTKc_Src	266..542	CDD:270656	89/280 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910