Protein Alignment wnd and BMX

DIOPT Version :10

• Sequence 1: NP_649137.3
• Gene: wnd / 40143
• FlyBaseID: FBgn0036896
• Length: 977
• Species: Drosophila melanogaster
• Sequence 2: NP_001712.1
• Gene: BMX / 660
• HGNCID: 1079
• Length: 675
• Species: Homo sapiens
• Alignment Length: 461
• Identity: 121/461 - (26%)
• Similarity: 195/461 - (42%)
• Gaps: 94/461 - (20%)

  Fly     9 SKSRDDLVTAASRQQQQLHGRRRHHGSSP-------------------NLSLDQTDNLRRSM--- 51
            |.|.:|:.::..:::...|...:.....|                   |:|..|::.|.|..
Human   252 SSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNISRSQSEQLLRQKGKE 316

  Fly    52 -ACLQDEFGHLGIAATDLPFKSSDLDSPPRLQH---HNNYAEITDSSAENTCQQRWPPHV----- 107
             |.:......:|:....| |..:..|....::|   |.| ||.....|||.|....|..:
Human   317 GAFMVRNSSQVGMYTVSL-FSKAVNDKKGTVKHYHVHTN-AENKLYLAENYCFDSIPKLIHYHQH 379

  Fly   108 --GGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTGVIEVKSQRSED--------WQIPFESIT 162
              .|......||                          :..|:.:..|        |::..|.||
Human   380 NSAGMITRLRHP--------------------------VSTKANKVPDSVSLGNGIWELKREEIT 418

  Fly   163 ELEWLGSGAQGAVFSGRLKNE-TVAVKKVKE--LKETDI----KHLRKLDHENIIKFKGVCTQSP 220
            .|:.||||..|.|..|:.|.: .||||.:||  :.|.:.    :.:.||.|..::||.|||::..
Human   419 LLKELGSGQFGVVQLGKWKGQYDVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEY 483

  Fly   221 VFCIIMEFCPYGPLQNILKEE-QVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNE 284
            ...|:.|:...|.|.|.|:.. :.:.||:|:.....:..||.:|.||:.|||||.:.|.|:..:.
Human   484 PIYIVTEYISNGCLLNYLRSHGKGLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDL 548

  Fly   285 VVKISDFGTSR------EWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTC- 342
            .||:||||.:|      ..:.:.||.    .|.|.||||......|.|.|:|::|:::||:.:.
Human   549 CVKVSDFGMTRYVLDDQYVSSVGTKF----PVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLG 609

  Fly   343 EIPYKDVDSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPEL 407
            :.||...|:|.::..|.... :|..|....:....::..||...|..||:|:|:||.:     |.
Human   610 KQPYDLYDNSQVVLKVSQGH-RLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSI-----EP 668

  Fly   408 LRKTEK 413
            ||:.:|
Human   669 LREKDK 674

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	82/250 (33%)
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944
		SH2_Tec_Bmx	289..394	CDD:198262	23/132 (17%)
		PTKc_Btk_Bmx	412..667	CDD:173657	86/264 (33%)
		CAV1-binding	596..603		2/6 (33%)