DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment wnd and si:ch211-45c16.2

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	XP_017213349.1	Gene:	si:ch211-45c16.2 / 568412	ZFINID:	ZDB-GENE-081105-15	Length:	982	Species:	Danio rerio

Alignment Length:	994	Identity:	374/994 - (37%)
Similarity:	498/994 - (50%)	Gaps:	197/994 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 RRRHHGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATD---LPFKSSDLDSPPRLQHHNNYAEI 90
            |.:.|..:..|.|.:.::.....:|.|...|..|....:   .|.:.|..|:     ||:.:.:|
Zfish   108 REQGHFENSVLQLQEQEDAETPGSCGQGGCGSGGEEKNEENGCPMEHSGDDT-----HHHPHDDI 167

  Fly    91 TDSSAENTCQQRWPPHVGGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTGVIEVK-SQRSEDW 154
                         ..|...||...|      |::.||.||::||.:.||||...|.| .|:.|.|
Zfish   168 -------------KLHFHRAGTGSG------GFLEGLFGCLRPVWNIIGKTYSTEYKLQQQVEMW 213

  Fly   155 QIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKHLRKLDHENIIKFKGVCTQS 219
            ::|||.|:||:|||||||||||.|:.::|.||:|||:|.|||||||||||.|.|||.|||||||:
Zfish   214 EVPFEEISELQWLGSGAQGAVFLGKFRSEEVAIKKVREQKETDIKHLRKLKHPNIISFKGVCTQA 278

  Fly   220 PVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHSHKIIHRDLKSPNILISTNE 284
            |.:|||||:|..|.|..:|:..:.:.|..||.|:..||.||.|||.||||||||||||:|::.|:
Zfish   279 PCYCIIMEYCAQGQLYEVLRAGRKITPCLLVDWASGIASGMNYLHLHKIIHRDLKSPNVLVTQND 343

  Fly   285 VVKISDFGTSREWNEISTKMSFAGTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDV 349
            .|||||||||:|.::.||||||||||||||||||||||.||||||||:||||||:||.|||||||
Zfish   344 SVKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDV 408

  Fly   350 DSSAIIWGVGNNSLKLLVPSTCPEGFKLLVKLCWKSKPRNRPSFRQILSHLDIAGPELLRKTEKQ 414
            ||||||||||:|||.|.||||||:|||:|:|..|:.||||||||||||.|||||..::|...::.
Zfish   409 DSSAIIWGVGSNSLHLPVPSTCPDGFKILMKQTWQGKPRNRPSFRQILLHLDIASADVLGTPQET 473

  Fly   415 YFETQKSWKEEVRSHLKEITQNGTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFEL 479
            ||:.|..|:|||:.|.::|...||.||:.:::||:||..|.|||.|||..||.||::.|.|:.||
Zfish   474 YFKCQTEWREEVKKHFEKIKSEGTCIHRLDEELIRRRRDELRHALDIREHYERKLERANNLYMEL 538

  Fly   480 SECMSQLQEKEKEIAER----ERKLPGSGYK-----PNRRFGNTIRKMQHYRRRLNPAPAAIQQQ 535
            |..|.||:.:|||:.:|    |:|.||: ||     |..| .|.:.|:...:..:|..|..  ||
Zfish   539 SAIMLQLEVREKELLKREQAVEKKYPGT-YKRHLVRPIVR-PNAVEKLIKKKSSMNHKPGT--QQ 599

  Fly   536 STTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSG------LGAPMPNKNKKVFRHRRNA 594
            ...||                             ::.|.|      |.||.|            .
Zfish   600 PKRPD-----------------------------LLRSDGIPSVEPLPAPSP------------L 623

  Fly   595 SGSFGAPPKYS-PTRDRRYQSEPENRKVQLVERQTQTDAMDVSETDISPSAEAPRSQPIDVPVPN 658
            |||    ||.| |....||:|:|.:|:           |......:..|....|.|.|.:...|.
Zfish   624 SGS----PKVSTPPGKTRYRSKPRHRR-----------ANSKGSHNEFPGVLKPNSGPPEEQQPL 673

  Fly   659 HRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACPSNG-NSLSTSELTYQDACSSPDQLIDD 722
            ..|..||...:.......|:.|..:.::.|..:....|:.. .|..|..|..:.:.|||| ||..
Zfish   674 QEQNYLQNHPLPPPEPPLAKTRENAVATCANNLRYFGPAAALRSPQTDHLQRRLSGSSPD-LIST 737

  Fly   723 VMNSNERL----------DMTECCSDNENLERLGRKVIEFINENRLSIQSNTNSVSNADNGNGGA 777
            .::::.||          .:..||..:   ...|.|..:.........|....|:.:.::|...|
Zfish   738 AVDADSRLRRSSIPPGPAPLCPCCQAH---PFPGCKHCQQTPAAPSHPQLPHYSLLSTNDGTPPA 799

  Fly   778 SPLEL------RESGNSPCLSRCSSTHSKRRKHPLGDNPNGSSIGNANGESHEQDSWSDEEGET- 835
            |...|      ::....|.|     .|:.|.....||            ||.|     :||||.
Zfish   800 SKRNLEPTAEGQDKEEKPAL-----LHTLRPLRKTGD------------ESSE-----EEEGEVD 842

  Fly   836 TDYKYALRRRSIGRQPIARGMRPRRSYKAPLSQKIAIHKRNVVIVSD-EEENTSEYSHS-PSSQH 898
            ::.::..|:|.      .|.|...:||....|:.::        ||| ||.|||::||| |..|.
Zfish   843 SEVEFPRRQRP------HRCMSSFQSYSTFSSENLS--------VSDGEEGNTSDHSHSGPLEQL 893

  Fly   899 S-------------TLESNTDIADMK-------------KTQAT----STSSNSYSEP---EDDS 930
            |             |.|...||:...             |||.:    ....:||..|   .|..
Zfish   894 SGSQEEHLDELLSHTPEIPIDISTQSDGLSDKECAVRRVKTQISLGKLCADEHSYENPLHFGDSD 958

  Fly   931 SDSSDEEQGNRPTEAKAEG 949
            .|:||.|..:.....|..|
Zfish   959 CDTSDAECSDATIRNKPPG 977

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	172/238 (72%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	171/235 (73%)
si:ch211-45c16.2	XP_017213349.1	STKc_MAP3K12_13	226..462	CDD:270961	171/235 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	359	1.000	Domainoid score	I918
eggNOG	1	0.900	-	-		E1_KOG4721
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	504	1.000	Inparanoid score	I1312
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003049
OrthoInspector	1	1.000	-	-		otm24504
orthoMCL	1	0.900	-	-		OOG6_105153
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2490
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.750