DRSC/TRiP Functional Genomics Resources

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Protein Alignment wnd and Ripk3

DIOPT Version :9

Sequence 1:NP_649137.3 Gene:wnd / 40143 FlyBaseID:FBgn0036896 Length:977 Species:Drosophila melanogaster
Sequence 2:NP_064339.2 Gene:Ripk3 / 56532 MGIID:2154952 Length:486 Species:Mus musculus


Alignment Length:536 Identity:129/536 - (24%)
Similarity:198/536 - (36%) Gaps:154/536 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   159 ESITELEWLGSGAQGAVFSG--RLKNETVAVKKVKELK-ETDIKHLRKLDHENIIKFKGVCTQSP 220
            |.:.:||::|.|..|.||..  |..|..||||.|...| ..::|.:..|.:||::...|| |:..
Mouse    20 EELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGV-TEDL 83

  Fly   221 VF------CIIMEFCPYGPLQNILKEEQVMLPSRLVSWSKQIALGMQYLHS--HKIIHRDLKSPN 277
            .:      .::..|...|.|..:|:.|.......|....:::.|||.||||  ..::|||||..|
Mouse    84 QWDFVSGQALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSN 148

  Fly   278 ILISTNEVVKISDFGTS-------REWNEISTKMSFAGTVAWMAPEVI--RNEPCSEKVDIWSYG 333
            ||:......|::|||.|       ......|......||:|::.||::  .|...|:..|::|:|
Mouse   149 ILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFG 213

  Fly   334 VVLWEMLT---CEIPYKDVDSSAIIWGV-----GNNSLKLLVPSTCPE--GFKLLVKL---CWKS 385
            :::|.:|.   .|:    ||.:::|...     ....|..|.|.: ||  |.:.|.:|   ||.|
Mouse   214 ILVWAVLAGREAEL----VDKTSLIRETVCDRQSRPPLTELPPGS-PETPGLEKLKELMIHCWGS 273

  Fly   386 KPRNRPSFRQ-----------ILSHLDIAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQNGTN 439
            :..|||||:.           :...:|.|..|:     |.|....:|....:.:  :|.:|.||.
Mouse   274 QSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEV-----KHYLSQHRSSGRNLSA--REPSQRGTE 331

  Fly   440 IHKYEQDLIKR----------------RTAEWRHAQDIRM-------VYEDKLQKTNQLFFELSE 481
            :....:.::.:                :..| |.|||..:       ...|.:..|.|:      
Mouse   332 MDCPRETMVSKMLDRLHLEEPSGPVPGKCPE-RQAQDTSVGPATPARTSSDPVAGTPQI------ 389

  Fly   482 CMSQLQEKEKEIAERERKLPGSGYKPNRRFGNTIRKMQHYRRRLNPAPAAIQQQS---------- 536
                           ...||..|..|...|..|            |.|...:.|.          
Mouse   390 ---------------PHTLPFRGTTPGPVFTET------------PGPHPQRNQGDGRHGTPWYP 427

  Fly   537 -TTPDPETTPESPVKCMLYAQLDSNCQPKSYLANIIPSSGLGAPMPNKNKKVFRHRRNASGSFGA 600
             |.|:|.|.|.        |.:.:||..              ..:.|.|..|...|..||.|   
Mouse   428 WTPPNPMTGPP--------ALVFNNCSE--------------VQIGNYNSLVAPPRTTASSS--- 467

  Fly   601 PPKYSPT---RDRRYQ 613
             .||...   |.|.:|
Mouse   468 -AKYDQAQFGRGRGWQ 482

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
wndNP_649137.3 STYKc 161..400 CDD:214568 81/282 (29%)
STKc_MAP3K12_13 167..403 CDD:270961 80/279 (29%)
Ripk3NP_064339.2 Pkinase 24..284 CDD:278497 81/265 (31%)
PKc_like 28..284 CDD:304357 79/261 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..333 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 349..388 7/39 (18%)
RHIM 410..457 CDD:289491 12/68 (18%)
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:18442983 440..461 5/34 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 462..486 8/25 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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