DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment wnd and slpr

DIOPT Version :9

Sequence 1:	NP_649137.3	Gene:	wnd / 40143	FlyBaseID:	FBgn0036896	Length:	977	Species:	Drosophila melanogaster
Sequence 2:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster

Alignment Length:	1129	Identity:	257/1129 - (22%)
Similarity:	423/1129 - (37%)	Gaps:	301/1129 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 RQQQQLHGRRRHHGSSPNLSLDQTDNLRRSMACLQDEFGHLGIAATDLPFKSSDLDSPPRLQHHN 85
            :||||....:.||...|.:.:...:.:...:.     .|.|..|..|...:..|
  Fly    12 QQQQQQQLEQLHHPQIPEIPIPDLEQVETQVG-----DGSLWTALYDYDAQGED----------- 60

  Fly    86 NYAEITDSSAENTCQQRWPPHVGGAGAAFGHPDKPIGWMYGLLGCMKPVLSFIGKTGVIEVKSQR 150
               |:|....|..........|.|          .:||..|.:|         .|.||.......
  Fly    61 ---ELTLRRGEIVVVLSTDSEVSG----------DVGWWTGKIG---------DKVGVFPKDFVT 103

  Fly   151 SED---------------WQIPFESITELEWLGSGAQGAVFSGRLKNETVAVKKVKELKETDIKH 200
            .||               .:|.:..:...|.:|||....|..|....|.||:|...:..|.|::.
  Fly   104 DEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQR 168

  Fly   201 LR-----------KLDHENIIKFKGVCTQSPVFCIIMEFCPYGPLQNILKEEQVMLPSRLVSWSK 254
            :|           .|.||||...:|||..:.: |::||:...|.|..||..:  :.|..||:|:.
  Fly   169 MRDNVLQEAKLFWALKHENIAALRGVCLNTKL-CLVMEYARGGSLNRILAGK--IPPDVLVNWAI 230

  Fly   255 QIALGMQYLHSH---KIIHRDLKSPNILI--------STNEVVKISDFGTSRE-WNEISTKMSFA 307
            |||.||.|||:.   .||||||||.|:||        ...:.:||:|||.:|| :|  :.:||.|
  Fly   231 QIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYN--TQRMSAA 293

  Fly   308 GTVAWMAPEVIRNEPCSEKVDIWSYGVVLWEMLTCEIPYKDVDSSAIIWGVGNNSLKLLVPSTCP 372
            ||.|||.||||.....|:..|:|||||:|||::|.|.|||..|..::.:||..|:|.|.:|.|||
  Fly   294 GTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCP 358

  Fly   373 EGFKLLVKLCWKSKPRNRPSFRQILSHLD-IAGPELLRKTEKQYFETQKSWKEEVRSHLKEITQN 436
            |.:..|:|.||::.|..||.|::||..|: ||..:.....::.:...|:.|::|:...|.::.:.
  Fly   359 ETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREK 423

  Fly   437 GTNIHKYEQDLIKRRTAEWRHAQDIRMVYEDKLQKTNQLFFELSECMSQLQEKEKEIAERE---- 497
            .......|::|   |..|    :.:..|..::.:|.|.|  ::.|  ..|:|:|:.:.|||
  Fly   424 EKRFQTIEEEL---RNKE----EQLLRVQNEQREKANLL--KIRE--QNLRERERVLIERELVML 477

  Fly   498 RKLP-------GSGYKPNR-----RFGNTIRKMQ----------------------HYRRRLNPA 528
            :.:|       |...||.:     .|.:||..::                      |..:...|:
  Fly   478 QPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPS 542

  Fly   529 PAAIQQQSTTPDPET--TPESPVKCMLYAQLDSNC---------QPKSYLANIIPSSGLGAPMPN 582
            ....:::|..|...:  .||.|.:...::....:.         |.:..:|::.|..|||.
  Fly   543 TMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGI---- 603

  Fly   583 KNKKVFRHRRNASGSFG---APPKYSP------TRDRRYQSEPENRKV-------QLVERQTQTD 631
                     ...||..|   |.|...|      ||       |.|..:       ..:...|.|.
  Fly   604 ---------LGGSGGAGGTPATPLLYPGIPIILTR-------PNNNNIGNCKAITTTITTTTTTT 652

  Fly   632 AMDVSETDISPSAEAPRSQPIDVPVPNHRQLPLQLQRVQKIAQAQARARSGSTSSAAGAVNPACP 696
            ..:.:..:.|.||.            |:.||       ..|:...:...:..|:..:........
  Fly   653 TNNNNNNNNSISAN------------NNNQL-------NNISTINSNNNNNQTNLTSQPNTIIVL 698

  Fly   697 SNGNSLSTSELTYQDACSSPDQLIDDVMNSNERLD------------MTECCSDNENLERLGRKV 749
            .||.:.|.|..|.|    ||.::.....:....||            :|:..|:.:
  Fly   699 QNGRNNSNSSTTSQ----SPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETD--------- 750

  Fly   750 IEFINENRLSIQSNTNSVSNADNGNGGASPLELR------ESGNSPCLSRCSSTHSKRRKHPLGD 808
                     ::.|.|.......:||..|:...:.      ..||||.:.|...:......||..:
  Fly   751 ---------TVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPAN 806

  Fly   809 NPNGSSIGNANGESHEQDSWSDEEGETTD---YKYALRRRSIGRQ------------------PI 852
            ..|..::.|       |.:...|:..|.|   |:..:::.|:...                  |:
  Fly   807 GSNSFALPN-------QLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTPL 864

  Fly   853 A-----------RGMRPRRSYKAPLSQKIAIHKRNVVIVSDEEENTSEYSHSPSSQHSTLESNTD 906
            .           .|.|.:|::..  ||    ..|:......|||..:|...:.:::..|.:::.|
  Fly   865 TARDCDDAEEAFEGGRFQRNFSG--SQ----FPRHCFFTRQEEEGEAEDEDAVAAEVDTADADAD 923

  Fly   907 ------IADMKKTQATSTSSN------SYSEPEDDSSDSSDEEQGNRPTEA-------KAEGPAL 952
                  .:.|::...||..|:      |:.||:..::..:........:.|       ::..|:|
  Fly   924 DECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFATYRSASPSL 988

  Fly   953 PMGAVRSSDIISIPTFEADGAVNM 976
            ...:..:|...||.:.||....:|
  Fly   989 SSSSTTASASPSIASTEAVNGYHM 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
wnd	NP_649137.3	STYKc	161..400	CDD:214568	107/261 (41%)
wnd	NP_649137.3	STKc_MAP3K12_13	167..403	CDD:270961	107/259 (41%)
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	16/89 (18%)
		TyrKc	129..386	CDD:197581	107/261 (41%)
		STKc_MLK	134..389	CDD:270963	107/259 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445250
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm1208
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840